on August 12, 2002
Published online before print August 12, 2002, doi: 10.1161/01.CIR.0000027568.39540.4B
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Submitted on April 23, 2002
From the Division of Cardiology (R.H.M., F.H., E.B., J.V.C., D.E.S., K.A.E.), University of Michigan, Ann Arbor; First Internal Medicine and Hypertension Center (R.M., F.P.), University of Ferrara, Ferrara, Italy; the Division of Cardiology (U.S.), Robert-Bosch Krankenhaus, Stuttgart, Germany; the Division of Cardiology (J.K.O.), Mayo Clinic, Rochester, Minn; the Division of Cardiology (M.P.), Cleveland Clinic Foundation, Cleveland, Ohio; the Division of Cardiology (S.H.), St Michael's Hospital, Toronto, Ontario, Canada; the Division of Cardiology (C.A.N.), University of Rostock, Rostock, Germany; and the Cardiology Division (E.M.I.), Massachusetts General Hospital, Boston, Mass. * To whom correspondence should be addressed. E-mail: rmehta{at}umich.edu.
Background—Chronobiological rhythms have been shown to influence the occurrence of a variety of cardiovascular disorders. However, the effects of the time of the day, the day of the week, or monthly/seasonal changes on acute aortic dissection (AAD) have not been well studied. Methods and Results—Accordingly, we evaluated 957 patients enrolled in the International Registry of Acute Aortic Dissection (IRAD) between 1996 and 2000 (mean age 62±14 years, type A 61%). A Conclusions—Similar to other cardiovascular conditions, AAD exhibits significant circadian and seasonal/monthly variations. Our findings may have important implications for the prevention of AAD by tailoring treatment strategies to ensure maximal benefits during the vulnerable periods.
Revised on June 11, 2002
Accepted on June 11, 2002
Chronobiological Patterns of Acute Aortic Dissection
Rajendra H. Mehta MD*,
2 test for goodness of fit and partial Fourier analysis were used to evaluate nonuniformity and rhythmicity of AAD during circadian, weekly, and monthly periods. A significantly higher frequency of AAD occurred from 6:00 AM to 12:00 noon compared with other time periods (12:00 noon to 6:00 PM, 6:00 PM to 12:00 midnight, and 12:00 midnight to 6:00 AM; P<0.001 by 2 test). Fourier analysis showed a highly significant circadian variation (P<0.001) with a peak between 8:00 AM and 9:00 AM. Although no significant variation was found for the day of the week, the frequency of AAD was significantly higher during winter (P=0.008 versus other seasons by 2 test). Fourier analysis confirmed this monthly variation with a peak in January (P<0.001). Subgroup analysis identified a significant association for all subgroups with circadian rhythmicity. However, seasonal/monthly variations were observed only among patients aged <70 years, those with type B AAD, and those without hypertension or diabetes.
Key words: aorta • circadian rhythm • seasons
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