on September 3, 2002
Published online before print September 3, 2002, doi: 10.1161/01.CIR.0000029927.92825.F6
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on March 29, 2002
From the Cardiology Division (H.Y., I.-K.J., D.-H.K.), Wellman Laboratories of Photomedicine (B.E.B., K.H.S., C.R.K., M.S., G.J.T.), Department of Pathology (S.L.H., H.T.A., G.J.T.), and Department of Radiology (E.F.H.), Massachusetts General Hospital and Harvard Medical School, Boston, and the First Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan (H.Y.). * To whom correspondence should be addressed. E-mail: tearney{at}helix.mgh.harvard.edu.
Background—High-resolution visualization of atherosclerotic plaque morphology may be essential for identifying coronary plaques that cause acute coronary events. Optical coherence tomography (OCT) is an intravascular imaging modality capable of providing cross-sectional images of tissue with a resolution of 10 µm. To date, OCT imaging has not been investigated in sufficient detail to assess its accuracy for characterizing atherosclerotic plaques. The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro. Methods and Results—OCT images of 357 (diseased) atherosclerotic arterial segments obtained at autopsy were correlated with histology. OCT image criteria for 3 types of plaque were formulated by analysis of a subset (n=50) of arterial segments. OCT images of fibrous plaques were characterized by homogeneous, signal-rich regions; fibrocalcific plaques by well-delineated, signal-poor regions with sharp borders; and lipid-rich plaques by signal-poor regions with diffuse borders. Independent validation of these criteria by 2 OCT readers for the remaining segments (n=307) demonstrated a sensitivity and specificity ranging from 71% to 79% and 97% to 98% for fibrous plaques, 95% to 96% and 97% for fibrocalcific plaques, and 90% to 94% and 90% to 92% for lipid-rich plaques, respectively (overall agreement, Conclusions—Objective OCT criteria are highly sensitive and specific for characterizing different types of atherosclerotic plaques. These results represent an important step in validating this new intravascular imaging modality and will provide a basis for the interpretation of intracoronary OCT images obtained from patients.
Revised on June 26, 2002
Accepted on June 26, 2002
Characterization of Human Atherosclerosis by Optical Coherence Tomography
Hiroshi Yabushita MD,
=0.83 to 0.84). The interobserver and intraobserver reliabilities of OCT assessment were high ( values of 0.88 and 0.91, respectively).
Key words: atherosclerosis • catheters • imaging • tomography • plaque
This article has been cited by other articles:
 |
|
 |
|
  A. Tanaka, T. Imanishi, H. Kitabata, T. Kubo, S. Takarada, T. Tanimoto, A. Kuroi, H. Tsujioka, H. Ikejima, S. Ueno, et al. Morphology of Exertion-Triggered Plaque Rupture in Patients With Acute Coronary Syndrome: An Optical Coherence Tomography Study Circulation, December 2, 2008; 118(23): 2368 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Kim, J.-S. Kim, E.-Y. Choi, D. Choi, and Y. Jang Catastrophic Thrombus Formation During Optical Coherence Tomography Circulation, August 5, 2008; 118(6): e101 - e102. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pasterkamp and I. Hoefer The visualization of the remodelling paradox Eur. Heart J., July 2, 2008; 29(14): 1704 - 1705. [Full Text] [PDF]
|
|
|
|
|
|
O. C. Raffel, F. M. Merchant, G. J. Tearney, S. Chia, D. D. Gauthier, E. Pomerantsev, K. Mizuno, B. E. Bouma, and I.-K. Jang In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography Eur. Heart J., July 2, 2008; 29(14): 1721 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Meng, B Lv, S Zhang, and B Yv In vivo optical coherence tomography of experimental thrombosis in a rabbit carotid model Heart, June 1, 2008; 94(6): 777 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sawada, J. Shite, H. M. Garcia-Garcia, T. Shinke, S. Watanabe, H. Otake, D. Matsumoto, Y. Tanino, D. Ogasawara, H. Kawamori, et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma Eur. Heart J., May 1, 2008; 29(9): 1136 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B X Chen, F Y Ma, W Luo, J H Ruan, W L Xie, X Z Zhao, S H Sun, X M Guo, F Wang, T Tian, et al. Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography Heart, May 1, 2008; 94(5): 566 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Suzuki, F. Ikeno, T. Koizumi, F. Tio, A. C. Yeung, P. G. Yock, P. J. Fitzgerald, and W. F. Fearon In Vivo Comparison Between Optical Coherence Tomography and Intravascular Ultrasound for Detecting Small Degrees of In-Stent Neointima After Stent Implantation J. Am. Coll. Cardiol. Intv., April 1, 2008; 1(2): 168 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, et al. Implication of Plaque Color Classification for Assessing Plaque Vulnerability: A Coronary Angioscopy and Optical Coherence Tomography Investigation J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 74 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Prati, M Zimarino, E Stabile, G Pizzicannella, T Fouad, R Rabozzi, A Filippini, J Pizzicannella, M Cera, and R De Caterina Does optical coherence tomography identify arterial healing after stenting? An in vivo comparison with histology, in a rabbit carotid model Heart, February 1, 2008; 94(2): 217 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Finn, G. Nakazawa, J. Narula, and R. Virmani Culprit Plaque in Myocardial Infarction: Going Beyond Angiography J. Am. Coll. Cardiol., December 4, 2007; 50(23): 2204 - 2206. [Full Text] [PDF]
|
|
|
|
|
|
R. Bhindi, S. M. Munir, and K. M. Channon Optical Coherence Tomography in the Setting of an Acute Anterior Myocardial Infarction Circulation, October 2, 2007; 116(14): e366 - e367. [Full Text] [PDF]
|
|
|
|
|
|
T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, et al. Assessment of Culprit Lesion Morphology in Acute Myocardial Infarction: Ability of Optical Coherence Tomography Compared With Intravascular Ultrasound and Coronary Angioscopy J. Am. Coll. Cardiol., September 4, 2007; 50(10): 933 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. C. Raffel, G. J. Tearney, D. D. Gauthier, E. F. Halpern, B. E. Bouma, and I.-K. Jang Relationship Between a Systemic Inflammatory Marker, Plaque Inflammation, and Plaque Characteristics Determined by Intravascular Optical Coherence Tomography Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1820 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney Measurement of Collagen and Smooth Muscle Cell Content in Atherosclerotic Plaques Using Polarization-Sensitive Optical Coherence Tomography J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1474 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Matsumoto, J. Shite, T. Shinke, H. Otake, Y. Tanino, D. Ogasawara, T. Sawada, O. L. Paredes, K.-i. Hirata, and M. Yokoyama Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography Eur. Heart J., April 2, 2007; 28(8): 961 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Waxman, F. Ishibashi, and J. E. Muller Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events Circulation, November 28, 2006; 114(22): 2390 - 2411. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ferencik, R. C. Chan, S. Achenbach, J. B. Lisauskas, S. L. Houser, U. Hoffmann, S. Abbara, R. C. Cury, B. E. Bouma, G. J. Tearney, et al. Arterial Wall Imaging: Evaluation with 16-Section Multidetector CT in Blood Vessel Phantoms and ex Vivo Coronary Arteries Radiology, September 1, 2006; 240(3): 708 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Papaspyridonos, A. Smith, K. G. Burnand, P. Taylor, S. Padayachee, K. E. Suckling, C. H. James, D. R. Greaves, and L. Patel Novel Candidate Genes in Unstable Areas of Human Atherosclerotic Plaques Arterioscler. Thromb. Vasc. Biol., August 1, 2006; 26(8): 1837 - 1844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I.-K. Jang, H. Fujiwara, and G. J. Tearney Diagnostic Accuracy of Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound Images for Tissue Characterization of Human Coronary Plaques J. Am. Coll. Cardiol., July 4, 2006; 48(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nasu, E. Tsuchikane, O. Katoh, D. G. Vince, R. Virmani, J.-F. Surmely, A. Murata, Y. Takeda, T. Ito, M. Ehara, et al. Accuracy of In Vivo Coronary Plaque Morphology Assessment: A Validation Study of In Vivo Virtual Histology Compared With In Vitro Histopathology J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2405 - 2412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Limbruno and R. De Caterina EMERALD, AIMI, and PROMISE: is there still a potential for embolic protection in primary PCI? Eur. Heart J., May 2, 2006; 27(10): 1139 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Stamper, N. J. Weissman, and M. Brezinski Plaque Characterization With Optical Coherence Tomography. J. Am. Coll. Cardiol., April 18, 2006; 47(8S): C69 - C79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Watanabe, S. Sugiyama, K. Kugiyama, O. Honda, H. Fukushima, H. Koga, Y. Horibata, T. Hirai, T. Sakamoto, M. Yoshimura, et al. Stabilization of Carotid Atheroma Assessed by Quantitative Ultrasound Analysis in Nonhypercholesterolemic Patients With Coronary Artery Disease J. Am. Coll. Cardiol., December 6, 2005; 46(11): 2022 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Nadkarni, B. E. Bouma, T. Helg, R. Chan, E. Halpern, A. Chau, M. S. Minsky, J. T. Motz, S. L. Houser, and G. J. Tearney Characterization of Atherosclerotic Plaques by Laser Speckle Imaging Circulation, August 9, 2005; 112(6): 885 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.K. Lovett, J.N.E. Redgrave, and P.M. Rothwell A Critical Appraisal of the Performance, Reporting, and Interpretation of Studies Comparing Carotid Plaque Imaging With Histology Stroke, May 1, 2005; 36(5): 1085 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, et al. In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography Circulation, March 29, 2005; 111(12): 1551 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura J. Thorac. Cardiovasc. Surg., March 1, 2005; 129(3): 615 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. MacNeill, I.-K. Jang, B. E. Bouma, N. Iftimia, M. Takano, H. Yabushita, M. Shishkov, C. R. Kauffman, S. L. Houser, H.T. Aretz, et al. Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery disease J. Am. Coll. Cardiol., September 1, 2004; 44(5): 972 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schoenhagen, S. S. Halliburton, A. E. Stillman, S. A. Kuzmiak, S. E. Nissen, E. M. Tuzcu, and R. D. White Noninvasive Imaging of Coronary Arteries: Current and Future Role of Multi-Detector Row CT Radiology, July 1, 2004; 232(1): 7 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. J. Schoepf, C. R. Becker, B. M. Ohnesorge, and E. K. Yucel CT of Coronary Artery Disease Radiology, July 1, 2004; 232(1): 18 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Langheinrich, R. M. Bohle, S. Greschus, N. Hackstein, G. Walker, S. von Gerlach, W. S. Rau, and H. Holschermann Atherosclerotic Lesions at Micro CT: Feasibility for Analysis of Coronary Artery Wall in Autopsy Specimens Radiology, June 1, 2004; 231(3): 675 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Tuzcu and P. Schoenhagen Acute coronary syndromes, plaque vulnerability,and carotid artery disease: The changing role ofatherosclerosis imaging J. Am. Coll. Cardiol., September 17, 2003; 42(6): 1033 - 1036. [Full Text] [PDF]
|
|
|
|
|
|
B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I.-K. Jang Intravascular Modalities for Detection of Vulnerable Plaque: Current Status Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1333 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Verheye, M. M. Kockx, S. W. Casscells, G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I.-K. Jang, B. MacNeill, E. F. Halpern, et al. Thermography to Detect Inflamed Macrophage-Rich Plaques * Response Circulation, June 10, 2003; 107 (22): e212 - e213. [Full Text] [PDF]
|
|
|
|
|
|
M. Oberhoff and K. R Karsch Who wants his plaque sealed? Eur. Heart J., March 2, 2003; 24(6): 494 - 495. [Full Text] [PDF]
|
|
|
|
|
|
B E Bouma, G J Tearney, H Yabushita, M Shishkov, C R Kauffman, D DeJoseph Gauthier, B D MacNeill, S L Houser, H T Aretz, E F Halpern, et al. Evaluation of intracoronary stenting by intravascular optical coherence tomography Heart, March 1, 2003; 89(3): 317 - 320. [Abstract] [Full Text] [PDF]
|
|