Published Online
on December 8, 2003

A more recent version of this article appeared on January 6, 2004

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Submitted on July 28, 2003
Revised on August 16, 2003
Accepted on September 22, 2003

Hostile Behaviors Predict Cardiovascular Mortality Among Men Enrolled in the Multiple Risk Factor Intervention Trial

Karen A. Matthews PhD^*, Brooks B. Gump PhD, Kelly F. Harris MS, Thomas L. Haney PhD, and John C. Barefoot PhD

From the University of Pittsburgh, Pittsburgh, Pa (K.A.M., K.F.H.); the State University of New York at Oswego (B.B.G.); and Duke University Medical Center, Durham, NC (T.L.H., J.C.B.).

^* To whom correspondence should be addressed. E-mail: matthewska{at}upmc.edu.

Background--Hostility is associated with incident coronary disease in most large population-based studies, but little is known about its association with cardiovascular disease (CVD) mortality in high-risk individuals. The aim of this study was to assess the association of hostility with CVD mortality in the subsequent 16 years in the Multiple Risk Factor Intervention Trial (MRFIT) participants and to explore the influence of hostility in the subset that had a nonfatal CVD event during the trial.

Methods and Results--We coded the Structured Interview responses of 259 men who died of CVD during the 16 years of follow-up and 259 matching living control subjects. Signs of hostility were assessed by use of the Interpersonal Hostility Assessment Technique. Matching was based on center, intervention group, age, race, and interviewer; covariates included study entry diastolic blood pressure, cholesterol, smoking status, and nonfatal CVD event during the trial. High-hostile men were more likely to die of CVD than were low-hostile men. Adjusted odds ratio (OR) and 95% confidence intervals (CIs) were 1.61, 1.09 to 2.39. After the trial, high-hostile men who also had a nonfatal event during the trial were particularly likely to die of CVD, OR, 5.06, 1.42 to 8.22, compared with low-hostile men without a nonfatal event during the trial.

Conclusions--Hostility may be a risk factor for CVD mortality among high-risk men. Interventions aimed at anger management and stress reduction along with risk factor modification may be useful for hostile patients.

Key words: hostility • survival • etiology • risk factors • cardiovascular diseases

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