Published Online
on October 4, 2004

A more recent version of this article appeared on October 12, 2004

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Submitted on May 24, 2004
Revised on July 29, 2004
Accepted on August 3, 2004

Impaired Cerebral Autoregulation in Patients With Malignant Hypertension

Rogier V. Immink MD, Bert-Jan H. van den Born MD, Gert A. van Montfrans MD, PhD, Richard P. Koopmans MD, PhD, John M. Karemaker PhD, and Johannes J. van Lieshout MD, PhD^*

From the Departments of Physiology (R.V.I., J.M.K.), Internal Medicine (B.-J.H.v.d.B., G.A.v.M., J.J.v.L.), and Pharmacology and Pharmacotherapy (R.P.K.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

^* To whom correspondence should be addressed. E-mail: j.j.vanlieshout{at}amc.uva.nl.

Background--In patients with a malignant hypertension, immediate parenteral treatment with blood pressure-lowering agents such as intravenous sodium nitroprusside (SNP) is indicated. In this study, we evaluated static and dynamic cerebral autoregulation (CA) during acute blood pressure lowering with SNP in these patients.

Methods and Results--In 8 patients with mean arterial pressure (MAP) >140 mm Hg and grade III or IV hypertensive retinopathy at hospital admission, middle cerebral artery blood velocity (MCA V) and blood pressure were monitored. Dynamic CA was expressed as the 0.1-Hz MCA V_mean to MAP phase lead and static CA as the MCA V_mean to MAP relationship during SNP treatment. Eight normotensive subjects served as a reference group. In the patients, the MCA V_mean to MAP phase lead was lower (30±8° versus 58±5°, mean±SEM; P<0.05), whereas the transfer gain tended to be higher. During SNP treatment, target MAP was reached within 90 minutes in all patients. The MCA V_mean decrease was 22±4%, along with a 27±3% reduction in MAP (from 166±4 to 121±6 mm Hg; P<0.05) in a linear fashion (averaged slope, 0.82±0.15% cm · s^-1 · % mm Hg^-1; r=0.70±0.07).

Conclusions--In patients with malignant hypertension, dynamic CA is impaired. An MCA V_mean plateau was not detected during the whole SNP treatment, indicating loss of static CA as well. This study showed that during the whole rapid reduction in blood pressure with SNP, MCA V_mean decreases almost one on one with MAP.

Key words: blood flow velocity • cerebrovascular circulation • hypertension • ultrasonics

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