Published Online
on November 1, 2004

A more recent version of this article appeared on November 9, 2004

This Article Full Text (PDF) All Versions of this Article: 110/19/3011    most recent 01.CIR.0000146894.45533.C2v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Damian, M. S. Articles by Georgi, C. Search for Related Content PubMed PubMed Citation Articles by Damian, M. S. Articles by Georgi, C. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Related Collections CPR and emergency cardiac care Neuroprotectors

Submitted on February 7, 2004
Revised on June 7, 2004
Accepted on July 16, 2004

Coenzyme Q10 Combined With Mild Hypothermia After Cardiac Arrest. A Preliminary Study

Maxwell Simon Damian MD, PhD^*, Diana Ellenberg MD, Ramona Gildemeister MD, Jörg Lauermann MD, Gregor Simonis MD, Wolfgang Sauter MD, and Christian Georgi MD

From the Department of Neurology, University Hospitals of Leicester, Leicester, United Kingdom (M.S.D.); and the Departments of Neurology (D.E., R.G., W.S.), Internal Medicine/Cardiology (J.L., G.S.), and Cardiothoracic Surgery (C.G.), University of Technology, Dresden, Germany.

^* To whom correspondence should be addressed. E-mail: msd13{at}le.ac.uk.

Background--Therapeutic hypothermia can improve survival after cardiopulmonary resuscitation (CPR). Coenzyme Q10 (CoQ10) has shown a protective effect in neurodegenerative disorders. We investigated whether combining mild hypothermia with CoQ10 after out-of-hospital cardiac arrest provides additional benefit.

Methods and Results--Forty-nine patients were randomly assigned to either hypothermia plus CoQ10 or hypothermia plus placebo after CPR. Hypothermia with a core temperature of 35°C was instituted for 24 hours. Liquid CoQ10 250 mg followed by 150 mg TID for 5 days or placebo was administered through nasogastric tube. Age, sex, premorbidity, cause of arrest, conditions of CPR, and degree of hypoxia were similar in both groups; no side effects of CoQ10 were identified. Three-month survival in the CoQ10 group was 68% (17 of 25) and 29% (7 of 24) in the placebo group (P=0.0413). Nine CoQ10 patients versus 5 placebo patients survived with a Glasgow Outcome Scale of 4 or 5. Mean serum S100 protein 24 hours after CPR was significantly lower in the CoQ10 group (0.47 versus 3.5 ng/mL).

Conclusions--Combining CoQ10 with mild hypothermia immediately after CPR appears to improve survival and may improve neurological outcome in survivors.

Key words: heart arrest • metabolism • brain • free radicals

This article has been cited by other articles:

				J. Qu, Y. Kaufman, and I. Washington Coenzyme Q10 in the Human Retina Invest. Ophthalmol. Vis. Sci., April 1, 2009; 50(4): 1814 - 1818. [Abstract] [Full Text] [PDF]

				B. P. Meloni, F. L. Mastaglia, and N. W. Knuckey Review: Therapeutic applications of hypothermia in cerebral ischaemia Therapeutic Advances in Neurological Disorders, September 1, 2008; 1(2): 75 - 98. [Abstract] [PDF]

				D. C. Bouch, J. P. Thompson, and M. S. Damian Post-cardiac arrest management: more than global cooling? Br. J. Anaesth., May 1, 2008; 100(5): 591 - 594. [Full Text] [PDF]