on December 6, 2004
Circulation. 2004
Published online before print December 6, 2004, doi: 10.1161/01.CIR.0000150390.04704.B7
Published online before print December 6, 2004, doi: 10.1161/01.CIR.0000150390.04704.B7
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Submitted on May 25, 2004
From the Cardiology Unit of the Department of Medicine (A.J.M., W.Z., A.D.E., M.W.B., J.P.D., S.M., M.L.A.) and the Department of Biostatistics and Computational Biology (W.J.H.), University of Rochester Medical Center, Rochester, NY, and the Cardiology Division of the Department of Medicine (H.G., R.B.C.), St. Luke’s Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, NY. * To whom correspondence should be addressed. E-mail: heartajm{at}heart.rochester.edu.
Background--The implanted cardioverter defibrillator (ICD) improves survival in high-risk cardiac patients. This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD. Methods and Results--Life-table survival analysis was performed, and proportional hazards regression analysis was used to evaluate the contribution of baseline clinical factors and time-dependent defibrillator therapy to mortality during long-term follow-up. Of 720 patients with an ICD (average follow-up 21 months), 169 patients received 701 antiarrhythmic device therapies for ventricular tachyarrhythmias. Few baseline characteristics distinguished patients who received appropriate ICD therapy for their first ventricular tachyarrhythmic episode. The probability of survival for at least 1 year after first therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF) was 80%. The hazard ratios for the risk of death due to any cause in those who survived appropriate therapy for termination of VT and VF were 3.4 (P<0.001) and 3.3 (P=0.01), respectively, compared with those who survived without receiving ICD therapy, with a high frequency of heart failure and late nonsudden cardiac death after first successful ICD therapy for VF. Conclusions--Successful appropriate therapy by an ICD for VT or VF is associated with 80% survival at 1 year after arrhythmia termination. These patients are at increased risk for heart failure and nonsudden cardiac death after device termination of VT or VF and should receive special attention for the prevention and management of progressive left ventricular dysfunction during long-term follow-up.
Revised on September 4, 2004
Accepted on September 27, 2004
Long-Term Clinical Course of Patients After Termination of Ventricular Tachyarrhythmia by an Implanted Defibrillator
Arthur J. Moss MD*,
Key words: tachycardia • fibrillation • heart-assist device • cardioversion • defibrillation
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