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(Circulation. 1950;1:343.)
© 1950 American Heart Association, Inc.

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Experimental Hypervolemic Heart Failure: Its Bearing on Certain General Principles of Heart Failure

WILLIAM HUCKABEE M.D.¹; GUS CASTEN M.D.¹; T. R. HARRISON M.D.¹

¹ From the Department of Internal Medicine, Southwestern Medical College, Dallas, Texas.

Infusion of large volumes of fluid into normal dogs produces a progressive rise in venous pressure with an initial parallel rise in cardiac output succeeded by a fall. On the basis of these experiments and other considerations which are discussed, it is concluded that the cardinal hemodynamic defect common to all types of heart failure is a disproportion between inflow load and cardiac output. The various general circulatory disorders are classified as primary disorders of filling and primary disorders of emptying with various subgroups.

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