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(Circulation. 1950;1:404.)
© 1950 American Heart Association, Inc.

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Circulatory Adjustments to the Hypoxemia of Congenital Heart Disease of the Cyanotic Type

HOWARD B. BURCHELL M.D.¹; BOWEN E. TAYLOR M.D.¹; JULIAN R. B. KNUTSON M.D.¹; EARL H. WOOD M.D., PH.D.¹

¹ From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

In a limited number of subjects having hypoxemia related to congenital malformations of the heart, no evidence was obtained of a correlation between the degree of hypoxemia or the extent of the polycythemia and the systemic blood flow. The circulatory response to exercise was characterized by a greater increase in the arteriovenous oxygen difference than in the systemic blood flow. A syncopal reaction in one patient was preceded by a greatly increased systemic blood flow and a small arteriovenous oxygen difference.