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(Circulation. 1954;10:331.)
© 1954 American Heart Association, Inc.

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Intravenous Trypsin

ALEXANDER TAYLOR M.B., CH.B. (EDIN.)¹ IRVING S. WRIGHT M.D.¹

¹ From the Department of Medicine of the Cornell University Medical College and the New York Hospital, New York, N. Y.

Studies were carried out regarding the effect of intravenous trypsin on rabbits. These included investigations into the toxicity and the tendency for the production of intravascular coagulation. The effect on artificial preformed thrombi was also observed. It was found that in the doses used, the intravenous administration of trypsin was not efficacious in the treatment of intravascular thrombosis. These studies failed to provide evidence to justify its use as a therapeutic agent in man.