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(Circulation. 1954;10:366.)
© 1954 American Heart Association, Inc.

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Effects of an Adrenergic Blocking Agent (Dibenzyline) upon Clinical Manifestations of Arterial Insufficiency in the Extremities

LOTHAR WERTHEIMER M.D.¹; WALTER REDISCH M.D.¹; J. MURRAY STEELE M.D.¹

¹ From the New York University Research Service, Goldwater Memorial Hospital and the Department of Medicine, New York University, College of Medicine, New York, N. Y.

Adrenergic blocking with Dibenzyline measurably enhances the healing of ischemic ulcers. Eleven cases of obliterative arterial disease and two cases of Raynaud's disease were closely observed and are reported in detail. In six of the individuals suffering from obliterative arterial disease, changes in blood flow were documented by plethysmography. Dibenzyline measurably influenced intermittent claudication only after prolonged administration (three to four months) in four out of eight closely observed patients without ulcers. The results of the physiologic tests suggest that during the early phases of adrenergic blocking the increase in blood flow is mostly in the skin, while in the later phases increase in blood flow through the muscle predominates.

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