(Circulation. 1999;100:1182-1188.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
Geometric Vascular Remodeling After Balloon Angioplasty and ß-Radiation Therapy
A Three-Dimensional Intravascular Ultrasound Study
From the Thoraxcenter, Heartcenter, Rotterdam, Dijkzigt Academisch Ziekenhuis Rotterdam, The Netherlands (M.S., P.W.S., W.J.v.d.G., J.M.R.L., I.P.K., A.L.G., A.J.W., A.d.B.); and the Daniel den Hoed Cancer Center, Rotterdam, The Netherlands (V.L.M.A.C., P.C.L.).
Correspondence to P.W. Serruys, MD, PhD, Department of Interventional Cardiology, Bd.412, Heartcenter, Academisch Ziekenhuis Rotterdam, PO Box 1738, Dr. Molewaterplein 40, 3000 DR Rotterdam, The Netherlands. E-mail serruys{at}card.azr.nl
Background—Endovascular radiation appears to inhibit intimal thickening after overstretching balloon injury in animal models. The effect of brachytherapy on vascular remodeling is unknown. The aim of the study was to determine the evolution of coronary vessel dimensions after intracoronary irradiation after successful balloon angioplasty in humans.
Methods and Results—Twenty-one consecutive patients treated with balloon angioplasty and ß-radiation according to the Beta Energy Restenosis Trial-1.5 were included in the study. Volumetric assessment of the irradiated segment and both edges was performed after brachytherapy and at 6-month follow-up. Intravascular ultrasound images were acquired by means of ECG-triggered pullback, and 3-D reconstruction was performed by automated edge detection, allowing the calculation of lumen, plaque, and external elastic membrane (EEM) volumes. In the irradiated segments, mean EEM and plaque volumes increased significantly (451±128 to 490.9±159 mm3 and 201.2±59 to 241.7±74 mm3; P=0.01 and P=0.001, respectively), whereas luminal volume remained unchanged (250.8±91 to 249.2±102 mm3; P=NS). The edges demonstrated an increase in mean plaque volume (26.8±12 to 32.6±10 mm3, P=0.0001) and no net change in mean EEM volume (71.4±24 to 70.9±24 mm3, P=NS), resulting in a decrease in mean luminal volume (44.6±16 to 38.3±16 mm3, P=0.01).
Conclusions—A different pattern of remodeling is observed in coronary segments treated with ß-radiation after successful balloon angioplasty. In the irradiated segments, the adaptive increase of EEM volume appears to be the major contributor to the luminal volume at follow-up. Conversely, both edges showed an increase in plaque volume without a net change in EEM volume.
Key Words: balloon • angioplasty • ultrasonics • remodeling • radioisotopes
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