(Circulation. 1999;100:1387-1393.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
Association Between Local Pulse Pressure, Mean Blood Pressure, and Large-Artery Remodeling
From the Departments of Pharmacology (P.B., C.B., B.L., S.L.) and Internal Medicine (X.G.), Broussais Hospital, and INSERM U337 (P.B., C.B., P.L., X.G., B.L., S.L.), Paris, France.
Background—The aim of the present study was to determine the respective influences of local pulse pressure and mean blood pressure on arterial remodeling in humans at 2 arterial sites: a central, predominantly elastic artery (the common carotid artery) and a peripheral muscular artery (the radial artery).
Methods and Results—Forty-three healthy subjects and 124 never-treated hypertensive patients were included in the study. Intima-media thickness and internal diameter of the carotid and radial arteries were noninvasively determined with high-definition echo-tracking devices. Pulse pressure was measured locally with applanation tonometry. Multivariate regression models including mean blood pressure and local pulse pressure were established in the whole population. Carotid internal diameter and intima-media thickness were strongly influenced (P<0.0001) by carotid pulse pressure but not by mean blood pressure or brachial pulse pressure, independently of age and sex. Radial artery internal diameter was correlated with age but not with mean blood pressure or radial pulse pressure. Radial artery intima-media thickness was correlated with mean blood pressure (P<0.001) but not with radial pulse pressure.
Conclusions—Carotid pulse pressure was a strong independent determinant of carotid artery enlargement and wall thickening, whereas mean blood pressure and brachial pulse pressure were not, indicating the prominent influence of local pulsatile mechanical load on arterial remodeling. These relationships were observed at the site of an elastic artery but not at the site of a muscular artery, suggesting the contribution of cyclic stretching to the pulse pressure–induced arterial remodeling.
Key Words: blood pressure • arteries • remodeling • hypertrophy • hypertension • carotid arteries
This article has been cited by other articles:
 |
|
 |
|
  R. Pini, M. C. Cavallini, V. Palmieri, N. Marchionni, M. Di Bari, R. B. Devereux, G. Masotti, and M. J. Roman Central but not brachial blood pressure predicts cardiovascular events in an unselected geriatric population: the ICARe Dicomano Study. J. Am. Coll. Cardiol., June 24, 2008; 51(25): 2432 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Edwards, M. S. Roy, and R. Y. Prasad Wave reflection augments central systolic and pulse pressures during facial cooling Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2535 - H2539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. McEniery, Yasmin, B. McDonnell, M. Munnery, S. M. Wallace, C. V. Rowe, J. R. Cockcroft, I. B. Wilkinson, and on Behalf of the Anglo-Cardiff Collaborative Trial Central Pressure: Variability and Impact of Cardiovascular Risk Factors: The Anglo-Cardiff Collaborative Trial II Hypertension, June 1, 2008; 51(6): 1476 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Sharman, C. M. McEniery, R. Campbell, P. Pusalkar, I. B. Wilkinson, J. S. Coombes, and J. R. Cockcroft Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise Hypertension, April 1, 2008; 51(4): 856 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Frimodt-Moller, A. H. Nielsen, A.-L. Kamper, and S. Strandgaard Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease Nephrol. Dial. Transplant., February 1, 2008; 23(2): 594 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Edwards, C. R. Mastin, and R. W. Kenefick Wave reflection and central aortic pressure are increased in response to static and dynamic muscle contraction at comparable workloads J Appl Physiol, February 1, 2008; 104(2): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Briet, C. Collin, S. Laurent, A. Tan, M. Azizi, M. Agharazii, X. Jeunemaitre, F. Alhenc-Gelas, and P. Boutouyrie Endothelial Function and Chronic Exposure to Air Pollution in Normal Male Subjects Hypertension, November 1, 2007; 50(5): 970 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Benjo, R. E. Thompson, D. Fine, C. W. Hogue, D. Alejo, A. Kaw, G. Gerstenblith, A. Shah, D. E. Berkowitz, and D. Nyhan Pulse Pressure Is an Age-Independent Predictor of Stroke Development After Cardiac Surgery Hypertension, October 1, 2007; 50(4): 630 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Heeneman, J. C. Sluimer, and M. J.A.P. Daemen Angiotensin-Converting Enzyme and Vascular Remodeling Circ. Res., August 31, 2007; 101(5): 441 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Korshunov, S. M. Schwartz, and B. C. Berk Vascular Remodeling: Hemodynamic and Biochemical Mechanisms Underlying Glagov's Phenomenon Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1722 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Roman, R. B. Devereux, J. R. Kizer, E. T. Lee, J. M. Galloway, T. Ali, J. G. Umans, and B. V. Howard Central Pressure More Strongly Relates to Vascular Disease and Outcome Than Does Brachial Pressure: The Strong Heart Study Hypertension, July 1, 2007; 50(1): 197 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Agabiti-Rosei, G. Mancia, M. F. O'Rourke, M. J. Roman, M. E. Safar, H. Smulyan, J.-G. Wang, I. B. Wilkinson, B. Williams, and C. Vlachopoulos Central Blood Pressure Measurements and Antihypertensive Therapy: A Consensus Document Hypertension, July 1, 2007; 50(1): 154 - 160. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Paini, P. Boutouyrie, D. Calvet, M. Zidi, E. Agabiti-Rosei, and S. Laurent Multiaxial Mechanical Characteristics of Carotid Plaque: Analysis by Multiarray Echotracking System Stroke, January 1, 2007; 38(1): 117 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Vlachopoulos, K Aznaouridis, and C Stefanadis Clinical appraisal of arterial stiffness: the Argonauts in front of the Golden Fleece Heart, November 1, 2006; 92(11): 1544 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Verdecchia, F. Angeli, and S. Taddei At the Beginning of Stiffening: Endothelial Dysfunction Meets "Pulsology" Hypertension, October 1, 2006; 48(4): 541 - 542. [Full Text] [PDF]
|
|
|
|
|
|
B. Ariff, A. Zambanini, S. Vamadeva, D. Barratt, Y. Xu, P. Sever, A. Stanton, A. Hughes, and S. Thom Candesartan- and Atenolol-Based Treatments Induce Different Patterns of Carotid Artery and Left Ventricular Remodeling in Hypertension Stroke, September 1, 2006; 37(9): 2381 - 2384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Sharman, R. Lim, A. M. Qasem, J. S. Coombes, M. I. Burgess, J. Franco, P. Garrahy, I. B. Wilkinson, and T. H. Marwick Validation of a Generalized Transfer Function to Noninvasively Derive Central Blood Pressure During Exercise Hypertension, June 1, 2006; 47(6): 1203 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Vlachopoulos, F. Kosmopoulou, N. Alexopoulos, N. Ioakeimidis, G. Siasos, and C. Stefanadis Acute mental stress has a prolonged unfavorable effect on arterial stiffness and wave reflections. Psychosom Med, March 1, 2006; 68(2): 231 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Paini, P. Boutouyrie, D. Calvet, A.-I. Tropeano, B. Laloux, and S. Laurent Carotid and Aortic Stiffness: Determinants of Discrepancies Hypertension, March 1, 2006; 47(3): 371 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Drager, L. A. Bortolotto, M. C. Lorenzi, A. C. Figueiredo, E. M. Krieger, and G. Lorenzi-Filho Early Signs of Atherosclerosis in Obstructive Sleep Apnea Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 613 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Vlachopoulos, D. Panagiotakos, N. Ioakeimidis, I. Dima, and C. Stefanadis Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1307 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Laurent, P. Boutouyrie, and P. Lacolley Structural and Genetic Bases of Arterial Stiffness Hypertension, June 1, 2005; 45(6): 1050 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Reneman, J. M. Meinders, and A. P.G. Hoeks Non-invasive ultrasound in arterial wall dynamics in humans: what have we learned and what remains to be solved Eur. Heart J., May 2, 2005; 26(10): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Sharman, Z. Y. Fang, B. Haluska, M. Stowasser, J. B. Prins, and T. H. Marwick Left Ventricular Mass in Patients With Type 2 Diabetes Is Independently Associated With Central but not Peripheral Pulse Pressure Diabetes Care, April 1, 2005; 28(4): 937 - 939. [Full Text] [PDF]
|
|
|
|
 |
|
 J.E. Sharman, J.R. Cockcroft, and J.S. Coombes Cardiovascular implications of exposure to traffic air pollution during exercise QJM, October 1, 2004; 97(10): 637 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Calvet, P. Boutouyrie, E. Touze, B. Laloux, J.-L. Mas, and S. Laurent Increased Stiffness of the Carotid Wall Material in Patients With Spontaneous Cervical Artery Dissection Stroke, September 1, 2004; 35(9): 2078 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Yasmin, C. M. McEniery, S. Wallace, I. S. Mackenzie, J. R. Cockcroft, and I. B. Wilkinson C-Reactive Protein Is Associated With Arterial Stiffness in Apparently Healthy Individuals Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 969 - 974. [Abstract] [Full Text]
|
|
|
|
|
|
R. M.A. Henry, P. J. Kostense, J. M. Dekker, G. Nijpels, R. J. Heine, O. Kamp, L. M. Bouter, and C. D.A. Stehouwer Carotid Arterial Remodeling: A Maladaptive Phenomenon in Type 2 Diabetes but Not in Impaired Glucose Metabolism: The Hoorn Study Stroke, March 1, 2004; 35(3): 671 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J.L. Vuurmans, P. Boer, and H. A. Koomans Effects of Endothelin-1 and Endothelin-1 Receptor Blockade on Cardiac Output, Aortic Pressure, and Pulse Wave Velocity in Humans Hypertension, June 1, 2003; 41(6): 1253 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Simon, P. Boutouyrie, J.M. Simon, B. Laloux, C. Tournigand, A.I. Tropeano, S. Laurent, and P. Jaillon Influence of Tamoxifen on Carotid Intima-Media Thickness in Postmenopausal Women Circulation, December 3, 2002; 106(23): 2925 - 2929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pini, M. C. Cavallini, F. Bencini, G. Silvestrini, E. Tonon, W. De Alfieri, N. Marchionni, M. Di Bari, R. B. Devereux, G. Masotti, et al. Cardiovascular remodeling is greater in isolated systolic hypertension than in diastolic hypertension in older adults: the Insufficienza Cardiaca negli Anziani Residenti (ICARE) a Dicomano Study J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1283 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Corpataux, E. Haesler, P. Silacci, H. B. Ris, and D. Hayoz Low-pressure environment and remodelling of the forearm vein in Brescia-Cimino haemodialysis access Nephrol. Dial. Transplant., June 1, 2002; 17(6): 1057 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Wilkinson, K. Prasad, I. R. Hall, A. Thomas, H. MacCallum, D. J. Webb, M. P. Frenneaux, and J. R. Cockcroft Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia J. Am. Coll. Cardiol., March 20, 2002; 39(6): 1005 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.S. Mackenzie, I.B. Wilkinson, and J.R. Cockcroft Assessment of arterial stiffness in clinical practice QJM, February 1, 2002; 95(2): 67 - 74. [Full Text] [PDF]
|
|
|
|
|
|
C. Vlachopoulos, K. Hirata, and M. F. O'Rourke Pressure-Altering Agents Affect Central Aortic Pressures More Than Is Apparent From Upper Limb Measurements in Hypertensive Patients: The Role of Arterial Wave Reflections Hypertension, December 1, 2001; 38(6): 1456 - 1460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Wilkinson, S. S. Franklin, I. R. Hall, S. Tyrrell, and J. R. Cockcroft Pressure Amplification Explains Why Pulse Pressure Is Unrelated to Risk in Young Subjects Hypertension, December 1, 2001; 38(6): 1461 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Boutouyrie, D. P. Germain, A.-I. Tropeano, B. Laloux, F. Carenzi, M. Zidi, X. Jeunemaitre, and S. Laurent Compressibility of the Carotid Artery in Patients With Pseudoxanthoma Elasticum Hypertension, November 1, 2001; 38(5): 1181 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Boutouyrie, S. Laurent, B. Laloux, O. Lidove, J.-P. Grunfeld, and D. P Germain Non-invasive evaluation of arterial involvement in patients affected with Fabry disease J. Med. Genet., September 1, 2001; 38(9): 629 - 631. [Full Text] [PDF]
|
|
|
|
|
|
C. Labat, P. Lacolley, M. Lajemi, M. de Gasparo, M. E. Safar, and A. Benetos Effects of Valsartan on Mechanical Properties of the Carotid Artery in Spontaneously Hypertensive Rats Under High-Salt Diet Hypertension, September 1, 2001; 38(3): 439 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boumaza, S. M. Arribas, M. Osborne-Pellegrin, J. C. McGrath, S. Laurent, P. Lacolley, and P. Challande Fenestrations of the Carotid Internal Elastic Lamina and Structural Adaptation in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, April 1, 2001; 37(4): 1101 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Dart and B. A. Kingwell Pulse pressure--a review of mechanisms and clinical relevance J. Am. Coll. Cardiol., March 15, 2001; 37(4): 975 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Boutouyrie, R. Corvisier, M. Azizi, D. Lemoine, B. Laloux, M.-C. Hallouin, and S. Laurent Effects of acupuncture on radial artery hemodynamics: controlled trials in sensitized and naive subjects Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H628 - H633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Nash Diabetes Mellitus and Cardiovascular Disease The Diabetes Educator, January 1, 2001; 27(1): 28 - 34. [PDF]
|
|
|
|
|
|
H. Tanaka, F. A. Dinenno, K. D. Monahan, C. A. DeSouza, and D. R. Seals Carotid Artery Wall Hypertrophy With Age Is Related to Local Systolic Blood Pressure in Healthy Men Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 82 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Liang, L. M. Shiel, H. Teede, D. Kotsopoulos, J. McNeil, J. D. Cameron, and B. P. McGrath Effects of Blood Pressure, Smoking, and Their Interaction on Carotid Artery Structure and Function Hypertension, January 1, 2001; 37(1): 6 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Boutouyrie, C. Bussy, D. Hayoz, J. Hengstler, N. Dartois, B. Laloux, H. Brunner, and S. Laurent Local Pulse Pressure and Regression of Arterial Wall Hypertrophy During Long-Term Antihypertensive Treatment Circulation, June 6, 2000; 101(22): 2601 - 2606. [Abstract] [Full Text] [PDF]
|
|