(Circulation. 2000;101:2503.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
In Vivo Magnetic Resonance Evaluation of Atherosclerotic Plaques in the Human Thoracic Aorta
A Comparison With Transesophageal Echocardiography
From the Zena and Michael A. Wiener Cardiovascular Institute (Z.A.F., T.N., J.T.F., M.G., J.G.A., J.J.B., M.S., J.H.C., V.F.), Departments of Radiology (Z.A.F.), Medicine (T.N., J.T.F., M.G., J.J.B., M.S., J.H.C., V.F.), and Pathology (J.T.F.), Mount Sinai School of Medicine, New York.
Correspondence to Zahi A. Fayad, PhD, Mount Sinai School of Medicine, Box 1234, New York, NY 10029. E-mail Zahi.Fayad{at}mssm.edu
Background—The structure and composition of aortic atherosclerotic plaques are associated with the risk of future cardiovascular events. Magnetic resonance (MR) imaging may allow accurate visualization and characterization of aortic plaques.
Methods and Results—We developed a noninvasive MR method, free of
motion and blood flow artifacts, for submillimeter imaging of the
thoracic aortic wall. MR imaging was performed on a clinical MR system
in 10 patients with aortic plaques identified by
transesophageal echocardiography
(TEE). Plaque composition, extent, and size were assessed from T1-,
proton density–, and T2- weighted images. Comparison of 25 matched MR
and TEE cross-sectional aortic plaque images showed a strong
correlation for plaque composition (
2=43.5,
P<0.0001; 80% overall agreement; n=25) and mean
maximum plaque thickness (r=0.88, n=25; 4.56±0.21
mm by MR and 4.62±0.31 mm by TEE). Overall aortic plaque extent
as assessed by TEE and MR was also statistically significant
(2=61.77, P<0.0001; 80% overall
agreement; n=30 regions).
Conclusions—This study demonstrates that noninvasive MR evaluation of the aorta compares well with TEE imaging for the assessment of atherosclerotic plaque thickness, extent, and composition. This MR method may prove useful for the in vivo study of aortic atherosclerosis.
Key Words: atherosclerosis • magnetic resonance imaging • aorta • echocardiography • plaque
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