(Circulation. 2000;101:2678.)
© 2000 American Heart Association, Inc.
Brief Rapid Communications |
Regulation of Angiotensin II Receptor Subtypes During Atrial Fibrillation in Humans
From University Hospital Magdeburg, Division of Cardiology (A.G., T.S., J.C.G., H.U.K), Institute of Immunology (M.A., A.S.), Institute of Pathology (C.R.), Department of Cardiovascular Surgery (C.H.), and Institute of Experimental Internal Medicine (S.A., U.L.), Magdeburg, Germany.
Correspondence to Andreas Goette, MD, University Hospital Magdeburg, Division of Cardiology, Leipziger Str 44, 39120 Magdeburg, Germany. E-mail andreas.goette{at}medizin.uni-madgeburg.de
Background—Previous studies have suggested that atrial fibrillation (AF) is associated with the activation of the atrial angiotensin system. However, it is not known whether the expression of angiotensin II receptors changes during AF. The purpose of this study was to determine the atrial expression of angiotensin II type 1 and type 2 receptors (AT1-R and AT2-R) in patients with AF.
Methods and Results—Atrial tissue samples from 30 patients
undergoing open heart surgery were examined. Eleven patients had
chronic persistent AF (
6 months; cAF), 8 patients had paroxysmal AF
(pAF), and 11 patients were in sinus rhythm. AT1-R and
AT2-R were localized in the atrial tissue by
immunohistochemistry and quantified at the protein and mRNA level by
Western blotting and quantitative polymerase chain reaction. Both types
of AT-R were predominantly expressed in atrial myocytes in all groups.
The amount of AT1-R was reduced to 34.9% during cAF
(P<0.01) and to 51.7% during pAF
(P<0.05) compared with patients in sinus rhythm. In
contrast, AT2-R was increased during cAF (246%;
P=NS) and pAF (505%; P<0.01).
AT1-R/AT2-R mRNA content was similar in all
groups.
Conclusions—AF is associated with the down-regulation of atrial AT1-R and the up-regulation of AT2-R proteins. These findings may help define the pathophysiological role of the angiotensin system in the structural remodeling of the fibrillating atria.
Key Words: angiotensin • atrium • fibrillation • receptors • remodeling
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