(Circulation. 2000;102:2823.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Noninvasive Coronary Angiography by Retrospectively ECG-Gated Multislice Spiral CT
From the Department of Internal Medicine II (S.A., D.R., T.G., W.G.D., W.M.), Institute of Medical Physics (S.U., M.K., W.A.K.), and Department of Diagnostic Radiology (U.B., W.B.), University of Erlangen-Nürnberg, Germany.
Correspondence to PD Dr Stephan Achenbach, Medizinische Klinik II mit Poliklinik, Universität Erlangen-Nürnberg, Östliche Stadtmauerstr 29, D-91054 Erlangen, Germany. E-mail stephan.achenbach{at}rzmail.uni-erlangen.de
Background—We investigated the applicability and image quality of contrast-enhanced coronary artery visualization by multislice spiral CT using retrospective ECG gating.
Methods and Results—Twenty-five patients in sinus rhythm (significant coronary artery stenoses ruled out by invasive angiography) were studied with a multislice spiral CT (Siemens SOMATOM Volume Zoom). In inspiration (mean breathhold, 37 seconds), a volume data set of the heart was acquired (intravenous contrast agent; 4x1-mm slice thickness; 500-ms rotation; table feed, 1.5 mm/360°). Simultaneous recording of the ECG permitted retrospective reconstruction of contiguous cross sections in intervals of 1 mm at any desired interval of the cardiac cycle. The mean duration of the image reconstruction window was 185 ms. Next to 3-dimensional reconstructions of the heart and coronary arteries, multiplanar reconstructions were rendered to determine the visualized length of the coronary arteries, the contrast-to-noise ratio, and the correlation of coronary artery diameters to quantitative coronary angiography.
Conclusions—The coronary arteries could be visualized over long segments (left main, 9±4 mm; left anterior descending, 112±34 mm; left circumflex, 80±29 mm; right coronary artery, 116±33 mm). On average, 78±16% of these distances were visualized free of motion artifacts. The mean contrast-to-noise ratio was 9.3±3.3. Coronary artery diameters in multislice spiral CT showed close correlation to quantitative coronary angiography (CT, 3.3±1.0 mm; angiography, 3.2±0.9 mm; mean difference, 0.38 mm; r=0.86). Contrast-enhanced multislice spiral CT permits visualization of the coronary artery lumen. Further studies are necessary to determine whether image quality is sufficient to reliably detect coronary artery stenoses.
Key Words: imaging • coronary disease • tomography
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 T. Nakanishi, Y. Kayashima, R. Inoue, K. Sumii, and Y. Gomyo Pitfalls in 16-Detector Row CT of the Coronary Arteries RadioGraphics, March 1, 2005; 25(2): 425 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
S Schroeder, A Kuettner, T Wojak, J Janzen, M Heuschmid, T Athanasiou, T Beck, C Burgstahler, C Herdeg, C D Claussen, et al. Non-invasive evaluation of atherosclerosis with contrast enhanced 16 slice spiral computed tomography: results of ex vivo investigations Heart, December 1, 2004; 90(12): 1471 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cademartiri, K. Nieman, A. van der Lugt, R. H. Raaijmakers, N. Mollet, P. M. T. Pattynama, P. J. de Feyter, and G. P. Krestin Intravenous Contrast Material Administration at 16-Detector Row Helical CT Coronary Angiography: Test Bolus versus Bolus-tracking Technique Radiology, December 1, 2004; 233(3): 817 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hoffmann, F. Moselewski, R. C. Cury, M. Ferencik, I.-k. Jang, L. J. Diaz, S. Abbara, T. J. Brady, and S. Achenbach Predictive Value of 16-Slice Multidetector Spiral Computed Tomography to Detect Significant Obstructive Coronary Artery Disease in Patients at High Risk for Coronary Artery Disease: Patient- Versus Segment-Based Analysis Circulation, October 26, 2004; 110(17): 2638 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kuettner, T. Trabold, S. Schroeder, A. Feyer, T. Beck, A. Brueckner, M. Heuschmid, C. Burgstahler, A. F. Kopp, and C. D. Claussen Noninvasive detection of coronary lesions using 16-detector multislice spiral computed tomography technology: Initial clinical results J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1230 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Viles-Gonzalez, M. Poon, J. Sanz, T. Rius, K. Nikolaou, Z. A. Fayad, V. Fuster, and J. J. Badimon In Vivo 16-Slice, Multidetector-Row Computed Tomography for the Assessment of Experimental Atherosclerosis: Comparison With Magnetic Resonance Imaging and Histopathology Circulation, September 14, 2004; 110(11): 1467 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Martuscelli, A. Romagnoli, A. D'Eliseo, C. Razzini, M. Tomassini, M. Sperandio, G. Simonetti, and F. Romeo Accuracy of thin-slice computed tomography in the detection of coronary stenoses Eur. Heart J., June 2, 2004; 25(12): 1043 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Desjardins and E. A. Kazerooni ECG-Gated Cardiac CT Am. J. Roentgenol., April 1, 2004; 182(4): 993 - 1010. [Full Text] [PDF]
|
|
|
|
|
|
A. Kuettner, A. F. Kopp, S. Schroeder, T. Rieger, J. Brunn, C. Meisner, M. Heuschmid, T. Trabold, C. Burgstahler, J. Martensen, et al. Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease J. Am. Coll. Cardiol., March 3, 2004; 43(5): 831 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Achenbach Detection of coronary stenoses by multidetector computed tomography: it's all about resolution J. Am. Coll. Cardiol., March 3, 2004; 43(5): 840 - 841. [Full Text] [PDF]
|
|
|
|
|
|
K. U. Juergens, M. Grude, D. Maintz, E. M. Fallenberg, T. Wichter, W. Heindel, and R. Fischbach Multi-Detector Row CT of Left Ventricular Function with Dedicated Analysis Software versus MR Imaging: Initial Experience Radiology, February 1, 2004; 230(2): 403 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Budoff, S. Achenbach, and A. Duerinckx Clinical utility of computed tomography and magnetic resonance techniques for noninvasive coronary angiography J. Am. Coll. Cardiol., December 3, 2003; 42(11): 1867 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G J Morgan-Hughes, P E Owens, C A Roobottom, and A J Marshall Three dimensional volume quantification of aortic valve calcification using multislice computed tomography Heart, October 1, 2003; 89(10): 1191 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Pannu, T. G. Flohr, F. M. Corl, and E. K. Fishman Current Concepts in Multi-Detector Row CT Evaluation of the Coronary Arteries: Principles, Techniques, and Anatomy RadioGraphics, October 1, 2003; 23(90001): S111 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Morgan-Hughes, P. E. Owens, A. J. Marshall, and C. A. Roobottom Thoracic Aorta at Multi-Detector Row CT: Motion Artifact with Various Reconstruction Windows Radiology, August 1, 2003; 228(2): 583 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hejmadi and D. J. Sahn What is the most effective method of detecting anomalous coronary origin in symptomatic patients? J. Am. Coll. Cardiol., July 2, 2003; 42(1): 155 - 157. [Full Text] [PDF]
|
|
|
|
|
|
A W Leber, A Knez, C Becker, A Becker, C White, C Thilo, M Reiser, R Haberl, and G Steinbeck Non-invasive intravenous coronary angiography using electron beam tomography and multislice computed tomography Heart, June 1, 2003; 89(6): 633 - 639. [Abstract] [Full Text] [PDF]
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R. L. Morin, T. C. Gerber, and C. H. McCollough Radiation Dose in Computed Tomography of the Heart Circulation, February 18, 2003; 107(6): 917 - 922. [Full Text] [PDF]
|
|
|
|
|
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|
|
|
|
|
K. Saito, M. Saito, S. Komatu, and K. Ohtomo Real-Time Four-dimensional Imaging of the Heart with Multi-Detector Row CT RadioGraphics, January 1, 2003; 23(1): e8 - e8. [Abstract] [Full Text]
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|
|
|
|
|
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|
|