(Circulation. 2001;103:429.)
© 2001 American Heart Association, Inc.
Basic Science Reports |
Gold-Coated NIR Stents in Porcine Coronary Arteries
From the Harvard-MIT Division of Health Sciences and Technology (E.R.E., P.S., A.G., D.B., C.R.) and the Department of Mechanical Engineering (A.M.), Massachusetts Institute of Technology, Cambridge, Mass, and the Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital and Harvard Medical School (E.R.E., C.R.), Boston, Mass.
Correspondence to Dr Elazer R. Edelman, Massachusetts Institute of Technology, Division of Health Sciences and Technology, 77 Massachusetts Ave, Room 16-343, Cambridge, MA 02139. E-mail ere{at}mit.edu
Background—As endovascular stents are altered to add functionality, eg, by adding radiopaque coatings, biocompatibility may suffer.
Methods and Results—We examined the vascular response in porcine coronary arteries to stainless steel gold-coated NIR stents (7-cell, Medinol, Inc). Stents, 9 and 16 mm in length, were left bare or coated with a 7-µm layer of gold. Physical and material effects were examined in four different gold-coated stent types, two at each length that either had the coating applied to the standard strut, ie, gold coated thicker than controls, or had the coating applied to thinned struts, ie, gold coated of the same thickness as control struts. Simple gold coating exacerbated intimal hyperplastic and inflammatory reactions over 28 days, but postplating thermal processing smoothed the coating surface and negated the adverse tissue response to gold. The relative amounts of base steel and gold coating and their resistances to expansion and collapse determined the extent of stent recoil.
Conclusions—Gold coatings enhance the radiopacity of steel stents, but not without effects on vascular repair. Material effects predominate and can be abrogated by heating coated stents to alter surface finish and material purity. Clinical results may suffer unless consideration is given to material and physical effects of gold.
Key Words: restenosis • stents • thermal processing • vasculature • vascular repair
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