This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Blaufox, A. D. Articles by Saul, J. P. Search for Related Content PubMed PubMed Citation Articles by Blaufox, A. D. Articles by Saul, J. P. Related Collections Ablation/ICD/surgery Arrhythmias, clinical electrophysiology, drugs

(Circulation. 2001;104:2803.)
© 2001 American Heart Association, Inc.

Clinical Investigation and Reports

Radiofrequency Catheter Ablation in Infants 18 Months Old

When Is It Done and How Do They Fare?: Short-Term Data From the Pediatric Ablation Registry

Andrew D. Blaufox, MD; Gary L. Felix, BS; J. Philip Saul, MD; , and Participating Members of the Pediatric Catheter Ablation Registry^*

From the Childrens’ Heart Program of South Carolina, Medical University of South Carolina, Charleston (A.D.B., J.P.S.), and the University of Nebraska/Creighton University Joint Division of Pediatric Cardiology, Children’s Hospital, Omaha (G.L.F.).

Correspondence to Andrew D. Blaufox, MD, Childrens’ Heart Program of South Carolina, Medical University of South Carolina, 165 Ashley Ave, PO Box 250915, Charleston, SC 29425. E-mail blaufoad{at}musc.edu

Background— The objective of this study was to determine the indications, the safety, and the efficacy of pediatric radiofrequency catheter ablation (RFCA) in infants.

Methods and Results— Data from the pediatric RFCA registry were reviewed. Between August 1989 and January 1999, 137 infants, defined by age 0 to 1.5 years (median 0.7 years; weight 1.9 to 14.8 kg, median 10 kg), underwent 152 procedures in 27 of 49 registry centers (55%), compared with 5960 noninfants undergoing 6610 procedures during a comparable period. Structural heart disease was present in 36% of infants, compared with 11.2% of noninfants (P<0.0001). RFCA in infants was performed more commonly for drug resistance or life-threatening arrhythmias than in noninfants. No differences were found between infants and noninfants in success for all tachycardia substrates (87.6% versus 90.6%, P=0.11), for single accessory pathways (94.5% versus 91.5%, P=0.4), or for total (7.8% versus 7.4%, P=1) and major (4.6% versus 2.9%, P=0.17) complications. Neither success for infants with a single accessory pathway nor complications for the entire infant group were related to weight, age, center size, or the presence of structural heart disease. Centers that performed infant procedures, however, enrolled more patients overall in the registry than those that did not perform infant procedures, and successful procedures in infants were performed by more experienced physicians than failed procedures.

Conclusions— Compared with noninfants, RFCA in infants is usually performed for drug resistance or life-threatening arrhythmias, often in the presence of structural heart disease. The data support the use of RFCA by experienced physicians in selected infants.

Key Words: catheter ablation • pediatrics • arrhythmia

This article has been cited by other articles:

				J. J. Blanc, J. Almendral, M. Brignole, M. Fatemi, K. Gjesdal, E. Gonzalez-Torrecilla, P. Kulakowski, G. Y.H. Lip, D. Shah, C. Wolpert, et al. Consensus document on antithrombotic therapy in the setting of electrophysiological procedures Europace, May 1, 2008; 10(5): 513 - 527. [Full Text] [PDF]

				D S Kothari and J R Skinner Neonatal tachycardias: an update. Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2006; 91(2): F136 - F144. [Abstract] [Full Text] [PDF]

				A. Hager, B. Zrenner, S. Brodherr-Heberlein, I. Steinbauer-Rosenthal, J. Schreieck, and J. Hess Congenital and surgically acquired Wolff-Parkinson-White syndrome in patients with tricuspid atresia J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 48 - 53. [Abstract] [Full Text] [PDF]

				A. Miyazaki, A. D. Blaufox, D. L. Fairbrother, and J. P. Saul Cryo-ablation for septal tachycardia substrates in pediatric patients: Mid-term results J. Am. Coll. Cardiol., February 15, 2005; 45(4): 581 - 588. [Abstract] [Full Text] [PDF]

				R. Mukherjee, A. M. Parkhurst, J. T. Mingoia, S. E. Sweterlitsch, J. S. Leiser, G. P. Escobar, F. G. Spinale, and J. P. Saul Myocardial remodeling after discrete radiofrequency injury: effects of tissue inhibitor of matrix metalloproteinase-1 gene deletion Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1242 - H1247. [Abstract] [Full Text] [PDF]

				J. C. Salerno, N. J. Kertesz, R. A. Friedman, and A. L. Fenrich Jr Clinical course of atrial ectopic tachycardia is age-dependent: results and treatment in children <3 or >=3 years of age J. Am. Coll. Cardiol., February 4, 2004; 43(3): 438 - 444. [Abstract] [Full Text] [PDF]

				Consider Catheter Ablation for Treating Arrhythmias in Infants Journal Watch Cardiology, January 25, 2002; 2002(125): 3 - 3. [Full Text]