(Circulation. 2001;104:365.)
© 2001 American Heart Association, Inc.
Current Perspectives |
Current Concepts of the Pathogenesis of the Acute Coronary Syndromes
From Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.
Correspondence to Peter Libby, MD, Cardiovascular Division, Department of Medicine, 221 Longwood Ave, LMRC 307, Boston, MA 02115. E-mail plibby@rics.bwh.harvard.edu
Key Words: angiotensin • myocardial infarction • atherosclerosis • inflammation • metalloproteinases • thrombosis
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Introduction |
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The last decade has witnessed a major reassessment of our perceptions about the acute coronary syndromes. Today, we recognize that thrombosis underlies most acute complications of atherosclerosis, notably unstable angina and acute myocardial infarction. A consensus has emerged that inflammation plays a decisive role in the pathophysiology of these acute thrombotic events (Figure 1). Knowledge of the underlying mechanisms has increased substantially since this topic was last reviewed in these pages 6 years ago. The present article provides an update of this rapidly moving field.
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