Circulation. 2002;106:2913-2918
Published online before print November 11, 2002, doi: 10.1161/01.CIR.0000041661.63285.AE
Published online before print November 11, 2002, doi: 10.1161/01.CIR.0000041661.63285.AE
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:2913.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
N-Terminal Pro-B–Type Natriuretic Peptide and Long-Term Mortality in Acute Coronary Syndromes
From the Department of Cardiology, National Hospital (T.O.), Oslo, Norway; Departments of Cardiology (M.H., J.H., T.K.) and Clinical Physiology (A.P., K.C.), Sahlgrenska University Hospital, Göteborg, Sweden; and Department of Medicine and Therapeutics (R.O.B., L.N.), University of Leicester, Leicester, UK.
Correspondence to Kenneth Caidahl, MD, PhD, Department of Clinical Physiology, Sahlgrenska University Hospital, SE-41345 Göteborg, Sweden. E-mail caidahl{at}clinphys.gu.se
Background— B-type natriuretic peptide (BNP) is a predictor of short- and medium-term prognosis across the spectrum of acute coronary syndromes (ACS). The N-terminal fragment of the BNP prohormone, N-BNP, may be an even stronger prognostic marker. We assessed the relation between subacute plasma N-BNP levels and long-term, all-cause mortality in a large, contemporary cohort of patients with ACS.
Methods and Results— Blood samples for N-BNP determination were obtained in the subacute phase in 204 patients with ST-elevation myocardial infarction (MI): 220 with non-ST segment elevation MI and 185 with unstable angina in the subacute phase. After a median follow-up of 51 months, 86 patients (14%) had died. Median N-BNP levels were significantly lower in long-term survivors than in patients dying (442 versus 1306 pmol/L; P<0.0001). The unadjusted risk ratio of patients with supramedian N-BNP levels was 3.9 (95% confidence interval, 2.4 to 6.5). In a multivariate Cox regression model, N-BNP (risk ratio 2.1 [95% confidence interval, 1.1 to 3.9]) added prognostic information above and beyond Killip class, patient age, and left ventricular ejection fraction. Adjustment for peak troponin T levels did not markedly alter the relation between N-BNP and mortality. In patients with no evidence of clinical heart failure, N-BNP remained a significant predictor of mortality after adjustment for age and ejection fraction (risk ratio, 2.4 [95% confidence interval, 1.1 to 5.4]).
Conclusions— N-BNP is a powerful indicator of long-term mortality in patients with ACS and provides prognostic information above and beyond conventional risk markers.
Key Words: angina • myocardial infarction • natriuretic peptides • prognosis • risk factors
Related Article:
Circulation 2002 106: 2868-2870.
This article has been cited by other articles:
 |
|
 |
|
  E. M. Kanoupakis, E. G. Manios, and P. E. Vardas Predicting future shocks in implantable cardioverter defibrillator recipients: the role of biomarkers Europace, November 1, 2009; 11(11): 1434 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hara, M. Nakamura, I. Yokouchi, K. Kimura, N. Nemoto, S. Ito, T. Ono, H. Itaya, M. Shiba, M. Wada, et al. Aggressive statin therapy in multicenter and effectiveness for the reduction of intra-myocardial damage caused by non-ST elevation acute coronary syndrome: AMERICA study Therapeutic Advances in Cardiovascular Disease, October 1, 2009; 3(5): 357 - 365. [Abstract] [PDF]
|
|
|
|
 |
|
 A. M. Jansson, P. Aukrust, T. Ueland, C. Smith, T. Omland, M. Hartford, and K. Caidahl Soluble CXCL16 Predicts Long-Term Mortality in Acute Coronary Syndromes Circulation, June 30, 2009; 119(25): 3181 - 3188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A.P. Weir, K. S. Chong, J. R. Dalzell, C. J. Petrie, C. A. Murphy, T. Steedman, P. B. Mark, T. A. McDonagh, H. J. Dargie, and J. J.V. McMurray Plasma apelin concentration is depressed following acute myocardial infarction in man Eur J Heart Fail, June 1, 2009; 11(6): 551 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Palmer, Z. H. Endre, A. M. Richards, and T. G. Yandle Characterization of NT-proBNP in Human Urine Clin. Chem., June 1, 2009; 55(6): 1126 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Lorgis, M Zeller, G Dentan, P Sicard, P Buffet, I L'Huillier, J C Beer, M Vincent-Martin, H Makki, P Gambert, et al. Prognostic value of N-terminal pro-brain natriuretic peptide in elderly people with acute myocardial infarction: prospective observational study BMJ, May 6, 2009; 338(may06_1): b1605 - b1605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Q. Khan, K. Ng, O. Dhillon, D. Kelly, P. Quinn, I. B. Squire, J. E. Davies, and L. L. Ng Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction Eur. Heart J., May 1, 2009; 30(9): 1057 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Jansson, H. Rosjo, T. Omland, T. Karlsson, M. Hartford, A. Flyvbjerg, and K. Caidahl Prognostic value of circulating chromogranin A levels in acute coronary syndromes Eur. Heart J., January 1, 2009; 30(1): 25 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Hamm, H. Möllmann, J.-P. Bassand, and F. van de Werf CHAPTER 16 Acute Coronary Syndromes ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Huelsmann, S. Neuhold, G. Strunk, D. Moertl, R. Berger, R. Prager, H. Abrahamian, M. Riedl, R. Pacher, A. Luger, et al. NT-proBNP has a high negative predictive value to rule-out short-term cardiovascular events in patients with diabetes mellitus Eur. Heart J., September 2, 2008; 29(18): 2259 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kelly, S. Q. Khan, M. Thompson, G. Cockerill, L. L. Ng, N. Samani, and I. B. Squire Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction Eur. Heart J., September 1, 2008; 29(17): 2116 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Neuhold, M. Huelsmann, G. Strunk, B. Stoiser, J. Struck, N. G. Morgenthaler, A. Bergmann, D. Moertl, R. Berger, and R. Pacher Comparison of Copeptin, B-Type Natriuretic Peptide, and Amino-Terminal Pro-B-Type Natriuretic Peptide in Patients With Chronic Heart Failure: Prediction of Death at Different Stages of the Disease J. Am. Coll. Cardiol., July 22, 2008; 52(4): 266 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Q. Khan, O. Dhillon, D. Kelly, I. B. Squire, J. Struck, P. Quinn, N. G. Morgenthaler, A. Bergmann, J. E. Davies, and L. L. Ng Plasma N-Terminal B-Type Natriuretic Peptide as an Indicator of Long-Term Survival After Acute Myocardial Infarction: Comparison With Plasma Midregional Pro-Atrial Natriuretic Peptide: The LAMP (Leicester Acute Myocardial Infarction Peptide) Study J. Am. Coll. Cardiol., May 13, 2008; 51(19): 1857 - 1864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zeller, C. Korandji, J.-C. Guilland, P. Sicard, C. Vergely, L. Lorgis, J.-C. Beer, L. Duvillard, A.-C. Lagrost, D. Moreau, et al. Impact of Asymmetric Dimethylarginine on Mortality After Acute Myocardial Infarction Arterioscler Thromb Vasc Biol, May 1, 2008; 28(5): 954 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Omland, T. Ueland, A. M. Jansson, A. Persson, T. Karlsson, C. Smith, J. Herlitz, P. Aukrust, M. Hartford, and K. Caidahl Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes. J. Am. Coll. Cardiol., February 12, 2008; 51(6): 627 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Q Khan, P Quinn, J E Davies, and L L Ng N-terminal pro-B-type natriuretic peptide is better than TIMI risk score at predicting death after acute myocardial infarction Heart, January 1, 2008; 94(1): 40 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Jeger, A. M. Lowe, C. E. Buller, M. E. Pfisterer, V. Dzavik, J. G. Webb, J. S. Hochman, U. P. Jorde, and for the SHOCK Investigators Hemodynamic Parameters Are Prognostically Important in Cardiogenic Shock But Similar Following Early Revascularization or Initial Medical Stabilization: A Report From the SHOCK Trial Chest, December 1, 2007; 132(6): 1794 - 1803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Westerhout, M. S. Lauer, S. James, Y. Fu, L. Wallentin, P. W. Armstrong, and for the GUSTO IV ACS Investigators Electrocardiographic left ventricular hypertrophy in GUSTO IV ACS: an important risk marker of mortality in women Eur. Heart J., September 1, 2007; 28(17): 2064 - 2069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.H. Wilson Tang, G. S. Francis, D. A. Morrow, L. K. Newby, C. P. Cannon, R. L. Jesse, A. B. Storrow, R. H. Christenson, COMMITTEE MEMBERS, R. H. Christenson, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure Circulation, July 31, 2007; 116(5): e99 - e109. [Full Text] [PDF]
|
|
|
|
|
|
T. Omland, M. S. Sabatine, K. A. Jablonski, M. M. Rice, J. Hsia, R. Wergeland, S. Landaas, J. L. Rouleau, M. J. Domanski, C. Hall, et al. Prognostic Value of B-Type Natriuretic Peptides in Patients With Stable Coronary Artery Disease: The PEACE Trial J. Am. Coll. Cardiol., July 17, 2007; 50(3): 205 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Q Khan, D. Kelly, P. Quinn, J. E Davies, and L. L Ng Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction Heart, July 1, 2007; 93(7): 826 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Marz, B. Tiran, U. Seelhorst, B. Wellnitz, J. Bauersachs, B. R. Winkelmann, and B. O. Boehm N-Terminal Pro-B-Type Natriuretic Peptide Predicts Total and Cardiovascular Mortality in Individuals with or without Stable Coronary Artery Disease: The Ludwigshafen Risk and Cardiovascular Health Study Clin. Chem., June 1, 2007; 53(6): 1075 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Q. Khan, O. S. Dhillon, R. J. O'Brien, J. Struck, P. A. Quinn, N. G. Morgenthaler, I. B. Squire, J. E. Davies, A. Bergmann, and L. L. Ng C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study Circulation, April 24, 2007; 115(16): 2103 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Q. Khan, R. J. O'Brien, J. Struck, P. Quinn, N. Morgenthaler, I. Squire, J. Davies, A. Bergmann, and L. L. Ng Prognostic Value of Midregional Pro-Adrenomedullin in Patients With Acute Myocardial Infarction: The LAMP (Leicester Acute Myocardial Infarction Peptide) Study J. Am. Coll. Cardiol., April 10, 2007; 49(14): 1525 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
NACB WRITING GROUP MEMBERS, D. A. Morrow, C. P. Cannon, R. L. Jesse, L. K. Newby, J. Ravkilde, A. B. Storrow, A. H.B. Wu, and R. H. Christenson National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes Circulation, April 3, 2007; 115(13): e356 - e375. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lorgis, M. Zeller, G. Dentan, P. Sicard, M. Jolak, I. L'Huillier, M. Vincent-Martin, J.C. Beer, H. Makki, P. Gambert, et al. High levels of N-terminal pro B-type natriuretic peptide are associated with ST resolution failure after reperfusion for acute myocardial infarction QJM, April 1, 2007; 100(4): 211 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
NACB WRITING GROUP MEMBERS, D. A. Morrow, C. P. Cannon, R. L. Jesse, L. K. Newby, J. Ravkilde, A. B. Storrow, A. H.B. Wu, R. H. Christenson, NACB COMMITTEE MEMBERS, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes Clin. Chem., April 1, 2007; 53(4): 552 - 574. [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. M. Corteville, K. Bibbins-Domingo, A. H. B. Wu, S. Ali, N. B. Schiller, and M. A. Whooley N-Terminal Pro-B-Type Natriuretic Peptide as a Diagnostic Test for Ventricular Dysfunction in Patients With Coronary Disease: Data From the Heart and Soul Study Arch Intern Med, March 12, 2007; 167(5): 483 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bibbins-Domingo, R. Gupta, B. Na, A. H. B. Wu, N. B. Schiller, and M. A. Whooley N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP), Cardiovascular Events, and Mortality in Patients With Stable Coronary Heart Disease JAMA, January 10, 2007; 297(2): 169 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Westerhout, Y. Fu, M. S. Lauer, S. James, P. W. Armstrong, E. Al-Hattab, R. M. Califf, M. L. Simoons, L. Wallentin, E. Boersma, et al. Short- and Long-Term Risk Stratification in Acute Coronary Syndromes: The Added Value of Quantitative ST-Segment Depression and Multiple Biomarkers J. Am. Coll. Cardiol., September 5, 2006; 48(5): 939 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Machado, A. Anthi, M. H. Steinberg, D. Bonds, V. Sachdev, G. J. Kato, A. M. Taveira-DaSilva, S. K. Ballas, W. Blackwelder, X. Xu, et al. N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA, July 19, 2006; 296(3): 310 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Galasko and R. Senior What is the most useful and cost-effective strategy to screen for left ventricular systolic dysfunction in clinical practice?: reply Eur. Heart J., June 1, 2006; 27(11): 1383 - 1383. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Laukkanen, S. Kurl, M. Ala-Kopsala, O. Vuolteenaho, H. Ruskoaho, K. Nyyssonen, and J. T. Salonen Plasma N-terminal fragments of natriuretic propeptides predict the risk of cardiovascular events and mortality in middle-aged men Eur. Heart J., May 2, 2006; 27(10): 1230 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Januzzi Jr, R. Sakhuja, M. O'Donoghue, A. L. Baggish, S. Anwaruddin, C. U. Chae, R. Cameron, D. G. Krauser, R. Tung, C. A. Camargo Jr, et al. Utility of amino-terminal pro-brain natriuretic Peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department. Arch Intern Med, February 13, 2006; 166(3): 315 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Talens-Visconti, M. Rivera Otero, M. J. Sancho-Tello, F. G. de Burgos, L. Martinez-Dolz, B. Sevilla, V. Climent, R. Cortes, A. Salvador, F. Sogorb, et al. Left ventricular cavity area reflects N-terminal pro-brain natriuretic peptide plasma levels in heart failure Eur J Echocardiogr, January 1, 2006; 7(1): 45 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Morrow, J. A. de Lemos, M. A. Blazing, M. S. Sabatine, S. A. Murphy, P. Jarolim, H. D. White, K. A. A. Fox, R. M. Califf, E. Braunwald, et al. Prognostic Value of Serial B-Type Natriuretic Peptide Testing During Follow-up of Patients With Unstable Coronary Artery Disease JAMA, December 14, 2005; 294(22): 2866 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ndrepepa, S. Braun, K. Niemoller, J. Mehilli, N. von Beckerath, O. von Beckerath, W. Vogt, A. Schomig, and A. Kastrati Prognostic Value of N-Terminal Pro-Brain Natriuretic Peptide in Patients With Chronic Stable Angina Circulation, October 4, 2005; 112(14): 2102 - 2107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Manios, E. M. Kallergis, E. M. Kanoupakis, H. E. Mavrakis, D. C. Kambouraki, D. A. Arfanakis, and P. E. Vardas Amino-Terminal Pro-Brain Natriuretic Peptide Predicts Ventricular Arrhythmogenesis in Patients With Ischemic Cardiomyopathy and Implantable Cardioverter-Defibrillators Chest, October 1, 2005; 128(4): 2604 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.D. Struthers and J. Davies B-type natriuretic peptide: a simple new test to identify coronary artery disease? QJM, October 1, 2005; 98(10): 765 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Binder, B. Pieske, M. Olschewski, A. Geibel, B. Klostermann, C. Reiner, and S. Konstantinides N-Terminal Pro-Brain Natriuretic Peptide or Troponin Testing Followed by Echocardiography for Risk Stratification of Acute Pulmonary Embolism Circulation, September 13, 2005; 112(11): 1573 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Verges, M. Zeller, J. Desgres, G. Dentan, Y. Laurent, L. Janin-Manificat, I. L'Huillier, G. Rioufol, J.-C. Beer, H. Makki, et al. High plasma N-terminal pro-brain natriuretic peptide level found in diabetic patients after myocardial infarction is associated with an increased risk of in-hospital mortality and cardiogenic shock Eur. Heart J., September 1, 2005; 26(17): 1734 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Stanton, M. Hansen, H. C. Wijeysundera, P. Kupchak, C. Hall, J. L. Rouleau, and On behalf of the PRAISE-2 study investigators A direct comparison of the natriuretic peptides and their relationship to survival in chronic heart failure of a presumed non-ischaemic origin Eur J Heart Fail, June 1, 2005; 7(4): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Carmona-Bernal, E. Quintana-Gallego, M. Villa-Gil, A. Sanchez-Armengol, A. Martinez-Martinez, and F. Capote Brain Natriuretic Peptide in Patients With Congestive Heart Failure and Central Sleep Apnea Chest, May 1, 2005; 127(5): 1667 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kistorp, I. Raymond, F. Pedersen, F. Gustafsson, J. Faber, and P. Hildebrandt N-Terminal Pro-Brain Natriuretic Peptide, C-Reactive Protein, and Urinary Albumin Levels as Predictors of Mortality and Cardiovascular Events in Older Adults JAMA, April 6, 2005; 293(13): 1609 - 1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ala-Kopsala, H. Ruskoaho, J. Leppaluoto, L. Seres, R. Skoumal, M. Toth, F. Horkay, and O. Vuolteenaho Single Assay for Amino-Terminal Fragments of Cardiac A- and B-Type Natriuretic Peptides Clin. Chem., April 1, 2005; 51(4): 708 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kragelund, B. Gronning, L. Kober, P. Hildebrandt, and R. Steffensen N-Terminal Pro-B-Type Natriuretic Peptide and Long-Term Mortality in Stable Coronary Heart Disease N. Engl. J. Med., February 17, 2005; 352(7): 666 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jarai, N. Iordanova, R. Jarai, A. Raffetseder, W. Woloszczuk, M. Gyongyosi, G. Geyer, J. Wojta, and K. Huber Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide Eur. Heart J., February 1, 2005; 26(3): 250 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueland, R. Jemtland, K. Godang, J. Kjekshus, A. Hognestad, T. Omland, I. B. Squire, L. Gullestad, J. Bollerslev, K. Dickstein, et al. Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction J. Am. Coll. Cardiol., November 16, 2004; 44(10): 1970 - 1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Heeschen, C. W. Hamm, V. Mitrovic, N.-H. Lantelme, H. D. White, and for the Platelet Receptor Inhibition in Ischemic S N-Terminal Pro-B-Type Natriuretic Peptide Levels for Dynamic Risk Stratification of Patients With Acute Coronary Syndromes Circulation, November 16, 2004; 110(20): 3206 - 3212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jarai, R. Jarai, and K. Huber N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease J. Am. Coll. Cardiol., November 2, 2004; 44(9): 1932 - 1932. [Full Text] [PDF]
|
|
|
|
|
|
S. Suzuki, M. Yoshimura, M. Nakayama, Y. Mizuno, E. Harada, T. Ito, S. Nakamura, K. Abe, M. Yamamuro, T. Sakamoto, et al. Plasma Level of B-Type Natriuretic Peptide as a Prognostic Marker After Acute Myocardial Infarction: A Long-Term Follow-Up Analysis Circulation, September 14, 2004; 110(11): 1387 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jernberg, S. James, B. Lindahl, N. Johnston, M. Stridsberg, P. Venge, and L. Wallentin Natriuretic peptides in unstable coronary artery disease Eur. Heart J., September 1, 2004; 25(17): 1486 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ala-Kopsala, J. Magga, K. Peuhkurinen, J. Leipala, H. Ruskoaho, J. Leppaluoto, and O. Vuolteenaho Molecular Heterogeneity Has a Major Impact on the Measurement of Circulating N-Terminal Fragments of A- and B-Type Natriuretic Peptides Clin. Chem., September 1, 2004; 50(9): 1576 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sadanandan, C. P. Cannon, K. Chekuri, S. A. Murphy, P. M. DiBattiste, D. A. Morrow, J. A. de Lemos, E. Braunwald, and C. M. Gibson Association of elevated B-type natriuretic peptide levels with angiographic findings among patients with unstable angina and non-ST-segment elevation myocardial infarction J. Am. Coll. Cardiol., August 4, 2004; 44(3): 564 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Larsen and K. Dickstein BNP in acute coronary syndromes: the heart expresses its suffering Eur. Heart J., August 1, 2004; 25(15): 1284 - 1286. [Full Text] [PDF]
|
|
|
|
|
|
A. Cochet, M. Zeller, Y. Cottin, C. Robert-Valla, A. Lalande, I. L'Huilllier, A. Comte, P. M. Walker, J. Desgres, J.-E. Wolf, et al. The extent of myocardial damage assessed by contrast-enhanced MRI is a major determinant of N-BNP concentration after myocardial infarction Eur J Heart Fail, August 1, 2004; 6(5): 555 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Galvani, F. Ottani, L. Oltrona, D. Ardissino, G. F. Gensini, A. P. Maggioni, P. M. Mannucci, N. Mininni, M. D. Prando, M. Tubaro, et al. N-Terminal Pro-Brain Natriuretic Peptide on Admission Has Prognostic Value Across the Whole Spectrum of Acute Coronary Syndromes Circulation, July 13, 2004; 110(2): 128 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M R Cowie B type natriuretic peptide testing: where are we now? Heart, July 1, 2004; 90(7): 725 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sharp and J. Mayet Review: The utility of BNP in clinical practice Journal of Renin-Angiotensin-Aldosterone System, June 1, 2004; 5(2): 53 - 58. [Abstract] [PDF]
|
|
|
|
|
|
O. Bazzino, J. J Fuselli, F. Botto, D. Perez de Arenaza, C. Bahit, J. Dadone, and for the PACS group of investigators Relative value of N-terminal probrain natriuretic peptide, TIMI risk score, ACC/AHA prognostic classification and other risk markers in patients with non-ST-elevation acute coronary syndromes Eur. Heart J., May 2, 2004; 25(10): 859 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Goetze, W. Yongzhong, J. F Rehfeld, E. Jorgensen, and J. Kastrup Coronary angiography transiently increases plasma pro-B-type natriuretic peptide Eur. Heart J., May 1, 2004; 25(9): 759 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Seino, A. Ogawa, T. Yamashita, M. Fukushima, K.-i. Ogata, H. Fukumoto, and T. Takano Application of NT-proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure Eur J Heart Fail, March 15, 2004; 6(3): 295 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Galvani, D. Ferrini, and F. Ottani Natriuretic peptides for risk stratification of patients with acute coronary syndromes Eur J Heart Fail, March 15, 2004; 6(3): 327 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. de Denus, C. Pharand, and D. R. Williamson Brain Natriuretic Peptide in the Management of Heart Failure: The Versatile Neurohormone Chest, February 1, 2004; 125(2): 652 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clerico and M. Emdin Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review Clin. Chem., January 1, 2004; 50(1): 33 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jernberg, B. Lindahl, A. Siegbahn, B. Andren, G. Frostfeldt, B. Lagerqvist, M. Stridsberg, P. Venge, and L. Wallentin N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease J. Am. Coll. Cardiol., December 3, 2003; 42(11): 1909 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. White and J. K. French Use of brain natriuretic peptide levels for risk assessment in non-ST-elevation acute coronary syndromes J. Am. Coll. Cardiol., December 3, 2003; 42(11): 1917 - 1920. [Full Text] [PDF]
|
|
|
|
|
|
L. L. Ng, I. Loke, J. E. Davies, K. Khunti, M. Stone, K. R. Abrams, D. T. Chin, and I. B. Squire Identification of previously undiagnosed left ventricular systolic dysfunction: community screening using natriuretic peptides and electrocardiography Eur J Heart Fail, December 1, 2003; 5(6): 775 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pruszczyk, M. Kostrubiec, A. Bochowicz, G. Styczynski, M. Szulc, M. Kurzyna, A. Fijalkowska, A. Kuch-Wocial, I. Chlewicka, and A. Torbicki N-terminal pro-brain natriuretic peptide in patients with acute pulmonary embolism Eur. Respir. J., October 1, 2003; 22(4): 649 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.R Cowie, P Jourdain, A Maisel, U Dahlstrom, F Follath, R Isnard, A Luchner, T McDonagh, J Mair, M Nieminen, et al. Clinical applications of B-type natriuretic peptide (BNP) testing Eur. Heart J., October 1, 2003; 24(19): 1710 - 1718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. James, B. Lindahl, A. Siegbahn, M. Stridsberg, P. Venge, P. Armstrong, E. S. Barnathan, R. Califf, E. J. Topol, M. L. Simoons, et al. N-Terminal Pro-Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV Substudy Circulation, July 22, 2003; 108(3): 275 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Richards, M. G. Nicholls, E. A. Espiner, J. G. Lainchbury, R. W. Troughton, J. Elliott, C. Frampton, J. Turner, I. G. Crozier, and T. G. Yandle B-Type Natriuretic Peptides and Ejection Fraction for Prognosis After Myocardial Infarction Circulation, June 10, 2003; 107(22): 2786 - 2792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ruskoaho Cardiac Hormones as Diagnostic Tools in Heart Failure Endocr. Rev., June 1, 2003; 24(3): 341 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. de Lemos and D. A. Morrow Brain Natriuretic Peptide Measurement in Acute Coronary Syndromes: Ready for Clinical Application? Circulation, December 3, 2002; 106(23): 2868 - 2870. [Full Text] [PDF]
|
|