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(Circulation. 1955;11:170.)
© 1955 American Heart Association, Inc.

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Treatment of Hypertension with Reserpine,with Reserpine in Combination with Pentapyrrolidinium,and with Reserpine in Combination with Veratrum Alkaloids

A. E. DOYLE M.D., M.R.C.P.¹; E. G. MCQUEEN M.B., M.R.C.P.¹; F. H. SMIRK M.D., F.R.C.P.¹

¹ From the Department of Medicine, Otago University Medical School, Dunedin, New Zealand.

The treatment of hypertension with reserpine is described. When used alone it produced adequatefalls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its parasympathetic side effects. The combination of reserpine and pentapyrrolidinium is regarded as the best therapeutic regime for severe hypertension. Some mild cases of hypertension may be managed with reserpine alone.