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(Circulation. 1955;11:182.)
© 1955 American Heart Association, Inc.

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Combined Rauwolfia-Hydralazine Therapy of Hypertensive Patients

CHARLES F. NAEGELE M.D.¹; RAY H. ROSENMAN M.D.¹; CHARLES L. HOFFMAN M.D.¹; MEYER FRIEDMAN M.D.¹

¹ From the Medical Service, United States Public Health Service Hospital, and the Harold Brunn Institute, Mount Zion Hospital, San Francisco,Calif.

Controlled blood pressure responses of 13 hospitalized and 33 ambulatory patients with essential or apparent renal hypertension were studied following combined Rauwolfia-hydralazine therapy. Adequate persistent lowering occurred in most instances of mild or moderate, and frequently even severe, hypertension. Prior and concomitant administration of Rauwolfia largely prevented unpleasant effects of hydralazine, permitted smaller dosage and ease of administration and follow-up—often impossible with large dosage of hydralazine used alone.

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				S. STONEHILL A Comparative Study of the Treatment of Essential Hypertension: The Effect of Rauwolfia and a Rauwolfia Compound (Rauwolfia, Mannitol Hexanitrate, and Rutin) Arch Intern Med, February 1, 1956; 97(2): 189 - 193. [Abstract] [PDF]