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(Circulation. 1955;11:593.)
© 1955 American Heart Association, Inc.

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Norepinephrine and Epinephrine Content of Normal and Diseased Human Hearts

WILHELM RAAB M.D.¹ WILDA GIGEE A.B.¹

¹ From the Division of Experimental Medicine and the Cardiovascular Research Unit of the University of Vermont, College of Medicine (Bishop DeGoesbriand Hospital), Burlington, Vermont.

Because of the exquisitely oxygen-wasting and potentially hypoxia-producing effect of epinephrine on the myocardium, its relative (compared with norepinephrine) and absolute concentration in 85 human hearts was investigated. Significant increases above normal were found in cases of fresh myocardial infarction, in congestive heart failure, and in renal uremia. It is believed that the hypoxiating action of excess epinephrine in the heart muscle constitutes an important pathogenic factor in the origin of certain forms of functional and degenerative heart disease. Prolonged illnesses of various kinds seem to reduce the myocardial norepinephrine content.

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