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(Circulation. 1955;11:615.)
© 1955 American Heart Association, Inc.

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Electrolyte Studies in Heart Failure

I. Cellular Factors in the Pathogenesis of the Edema of Congestive Heart Failure

LLOYD T. ISERI M.D.¹; ALBERT J. BOYLE M.D., PH.D.¹; DOUGLAS E. CHANDLER M.D.¹; GORDON B. MYERS M.D.¹

¹ From the Departments of Medicine, City of Detroit Receiving Hospital and Wayne University College of Medicine, Detroit, Mich.

Muscle analyses for water, potassium, and chloride were made in 10 cardiac patients during and after congestive heart failure. The potassium content per unit of wet tissue during failure was 30.1 per cent less than that during compensation. The concentration of potassium in the intracellular water increased from 116 mEq. per liter to 151 mEq. per liter with compensation. Calculated extracellular water decreased, but no change in intracellular water per unit of tissue solids was found.