This Article Full Text Full Text (PDF) All Versions of this Article: 110/18/2786    most recent 01.CIR.0000146335.69413.F9v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cogliati, C. Articles by Furlan, R. Search for Related Content PubMed PubMed Citation Articles by Cogliati, C. Articles by Furlan, R. Related Collections Cardiovascular Pharmacology Autonomic, reflex, and neurohumoral control of circulation Related Article

(Circulation. 2004;110:2786-2791.)
© 2004 American Heart Association, Inc.

Arrhythmia/Electrophysiology

Acute ß-Blockade Increases Muscle Sympathetic Activity and Modifies Its Frequency Distribution

Chiara Cogliati, MD; Simona Colombo, MD; Tomaso Gnecchi Ruscone, MD; Domenico Gruosso, MD; Alberto Porta, PhD; Nicola Montano, MD, PhD; Alberto Malliani, MD; Raffaello Furlan, MD

From Medicina Interna II, Ospedale L. Sacco, Milano (C.C., N.M., A.M., R.F.); Dipartimento Scienze Precliniche LITA di Vialba (A.P.); Università degli Studi di Milano, Divisioni di Cardiologia, Ospedali di Rho (S.C.) e Merate (T.G.R.), Milano; and Medicina Interna, Università Seconda, Napoli (D.G.), Italy.

Correspondence to Dr Raffaello Furlan, Unità Sincopi e Disturbi della Postura, Medicina Interna II, Ospedale L. Sacco, Università di Milano, Via G.B. Grassi 74, 20157 Milano, Italy. E-mail raffaellof{at}fisiopat.sacco.unimi.it

Received February 27, 2003; de novo received December 16, 2003; revision received March 30, 2004; accepted April 2, 2004.

Background— The possible mechanisms by which ß-adrenergic antagonists may act on the neural regulation of the cardiovascular system are still elusive. Recent studies reported a marked increase of postganglionic muscle sympathetic nerve activity (MSNA) after acute ß-blockade associated with unchanged values of arterial blood pressure and baroreflex sensitivity. We tested the hypothesis that acute ß-blockade might also alter the oscillatory characteristics of MSNA, thus decreasing its effectiveness on peripheral vasoconstriction.

Methods and Results— In 11 healthy volunteers, ECG, MSNA, arterial pressure, and respiration were recorded before and after atenolol (0.05 mg/kg IV bolus) administration. The frequency distribution of RR interval, MSNA, systolic arterial pressure (SAP), and respiratory variability was assessed by spectrum and cross-spectrum analysis. Spontaneous baroreflex sensitivity (-index) and plasma catecholamines (high-performance liquid chromatography) were measured. Atenolol induced a significant increase in RR interval (14.3±1.6%) with no changes in systolic and diastolic arterial pressure. MSNA increased (42±13% from 18±2 bursts per minute). The low-frequency (LF) component of RR and MSNA variability decreased (–44±7% and –24±5%, respectively), whereas the high-frequency (HF) component increased (163±55% and 34±11%, respectively), expressed in normalized units. Spectral coherence, an index of oscillatory coupling, decreased between LF_RR and LF_MSNA, whereas it increased between HF_MSNA and HF_Resp. SAP variability, -index, and plasma catecholamines remained unchanged.

Conclusions— Atenolol induced a change in MSNA frequency distribution reflecting a stronger respiratory coupling. This shift toward high frequency, despite an increase in MSNA, may lead to a less efficient sympathetic vasomotor modulation.

Key Words: adrenergic ß-antagonists • nervous system, sympathetic • nervous system, autonomic • baroreceptors

Related Article:

Circulation 2004 110: 2773. [Extract] [Full Text]

This article has been cited by other articles:

				S.P. Beloka, S. Gouveia, M. Gujic, R. Naeije, A.P. Rocha, and P. van de Borne Differential Effects of Oral {beta} Blockade on Cardiovascular and Sympathetic Regulation Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2009; 14(4): 323 - 331. [Abstract] [PDF]

				N. Montano, R. Furlan, S. Guzzetti, R. M McAllen, and C. Julien Analysis of sympathetic neural discharge in rats and humans Phil Trans R Soc A, April 13, 2009; 367(1892): 1265 - 1282. [Abstract] [Full Text] [PDF]

				T Lanki, G Hoek, K L Timonen, A Peters, P Tiittanen, E Vanninen, and J Pekkanen Hourly variation in fine particle exposure is associated with transiently increased risk of ST segment depression Occup. Environ. Med., November 1, 2008; 65(11): 782 - 786. [Abstract] [Full Text] [PDF]

				A. U. Viola, L. M. James, S. N. Archer, and D.-J. Dijk PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2156 - H2163. [Abstract] [Full Text] [PDF]

				G. A. Lanza, D. Pitocco, E. P. Navarese, A. Sestito, G. A. Sgueglia, A. Manto, F. Infusino, T. Musella, G. Ghirlanda, and F. Crea Association between cardiac autonomic dysfunction and inflammation in type 1 diabetic patients: effect of beta-blockade Eur. Heart J., April 1, 2007; 28(7): 814 - 820. [Abstract] [Full Text] [PDF]

				A. Malliani, N. Montano, Q. Fu, and B. D. Levine Antihypertensive Treatment and Sympathetic Excitation * Response Hypertension, September 1, 2005; 46(3): e8 - e8. [Full Text] [PDF]

				F. Holmqvist, M. Stridh, J. E. P. Waktare, J. Brandt, L. Sornmo, A. Roijer, and C. J. Meurling Rapid fluctuations in atrial fibrillatory electrophysiology detected during controlled respiration Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H754 - H760. [Abstract] [Full Text] [PDF]