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(Circulation. 1958;17:176.)
© 1958 American Heart Association, Inc.

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Serum Cholesterol in Pentolinium -Treated Arterial Hypertension

HAROLD H. ORVIS M.D.¹; IRENE G. TAMAGNA M.D.¹; JOHN M. EVANS M.D.¹

¹ From the Department of Medicine, The George Washington University School of Medicine, Washington, D. C.

Serum lipids were serially determined in 11 patients receiving pentolinium therapy to evaluate changes secondary to blood pressure effects. Substantial reduction in total Cholesterol was observed, which in some cases was independent of the hypotensive effect of the drug. Fat absorption, studied in 6 patients, revealed diminished postprandial lipemia in each as compared to placebo determinations. However, few patients showed appreciable weight change during a year of therapy. The evidence suggests that the serum lipid changes secondary to pentolinium administration are due to a qualitative change in fat absorption.