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(Circulation. 1966;33:I-86.)
© 1966 American Heart Association, Inc.

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Use of Corticosteroids During Cardiopulmonary Bypass: Possible Lysosome Stabilization

ROBERT L. REPLOGLE M.D.¹; ALAN B. GAZZANIGA M.D.¹; ROBERT E. GROSS M.D.¹

¹ From the Laboratory for Surgical Research, Children's Hospital Medical Center, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts.

1. These studies suggest that massive doses of dexamethasone may stabilize the lysosome membrane during periods of circulatory stress.

2. Some of the postoperative complications following cardiopulmonary bypass may be related in part to lysosome damage incurred during bypass.