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(Circulation. 1969;40:13.)
© 1969 American Heart Association, Inc.

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Differences in Bile Acid Excretion

Primary Hypercholesteremia Compared to Combined Hypercholesteremia and Hypertriglyceridemia

BRUCE A. KOTTKE M.D., PH.D.¹

¹ From the Mayo Clinic and Mayo Foundation: Section of Medicine. Rochester, Minnesota.

Total daily bile acid excretion was measured in 10 patients with primary hypercholesteremia and in nine patients with combined hypercholesteremia and hypertriglyceridemia by using ¹⁴C-labeled cholic acid and ³H-labeled chenodeoxycholic acid. The average bile acid excretion by the patients with primary hypercholesteremia was 282 mg/day; that by the patients with combined hypercholesteremia and hypertriglyceridemia, 1,094 mg/day. These findings suggest a fundamental difference in cholesterol metabolism in these two types of hyperlipidemia.

Key Words: Hyperlipidemia • Thin layer chromatography • Isotopes • Cholesterol excretion