This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by ROSENBERG, H. G. Search for Related Content PubMed PubMed Citation Articles by ROSENBERG, H. G.

(Circulation. 1973;47:270.)
© 1973 American Heart Association, Inc.

---

Systemic Arterial Disease with Myocardial Infarction

Report on Two Infants

HELMAR G. ROSENBERG M.D.¹

¹ From the Clinical Hospital, Catholic University of Chile, Santiago, Chile.

This report deals with two cases of infants who died of myocardial infarction. Autopsy revealed an occlusive, diffuse, generalized lesion in medium and small-sized arteries, with particular involvement of the heart, skin, gastrointestinal tract, kidneys, pancreas, and liver. It showed a fibrous thickening of the intima; the internal lamina elastica, the media, and the adventitia remained unchanged. A pathogenic interpretation of the vascular lesions is attempted, and their asynchronism in the most seriously involved organs is pointed out. The vascular lesions have a great resemblance to those seen in progressive arterial occlusive disease. Despite the antecedent of chronic arsenic poisoning through drinking water, no demonstrable etiologic evidence was found in the vascular lesions; nevertheless, its connection with arsenic, as in blackfoot disease, should be considered.

Key Words: Blackfoot disease • Arsenic poisoning • Arteriosclerosis

Submitted on December 21, 1971
Accepted on October 12, 1972

This article has been cited by other articles:

				J. C. States, S. Srivastava, Y. Chen, and A. Barchowsky Arsenic and Cardiovascular Disease Toxicol. Sci., February 1, 2009; 107(2): 312 - 323. [Abstract] [Full Text] [PDF]

				H. G. Rosenberg and M. V. Muller Arteriosclerotic Ulcer of Legs Without Occlusive Arterial Disease Angiology, August 1, 1977; 28(8): 561 - 567. [Abstract] [PDF]