This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pagani, M. Articles by Braunwald, E. Search for Related Content PubMed PubMed Citation Articles by Pagani, M. Articles by Braunwald, E.

Circulation, Vol 57, 144-151, Copyright © 1978 by American Heart Association

ARTICLES

Hemodynamic effects of intravenous sodium nitroprusside in the conscious dog

M Pagani, SF Vatner and E Braunwald

The hemodynamic effects of 7 min i.v. sodium nitroprusside (NP) were studied in conscious dogs previously instrumented for measurement of arterial pressure, cardiac output, regional blood flow distribution, left ventricular (LV) pressure, and internal dimensions. Nitroprusside, 25 microgram/kg/min, reduced mean arterial pressure by 23 +/- 3%. Cardiac output increased initially by 39 +/- 7% and returned toward control by the end of the infusion. Regional blood flows increased initially; the relative rise was greatest in the coronary (+ 225 +/- 39%), intermediate in the mesenteric (+ 98 +/- 23%) and iliac (+ 38 +/- 6%), and least in the renal (+ 10 +/- 3%) bed. By the end of the infusion period the vasodilation was unchanged in the iliac bed, less intense in the coronary and mesenteric, while in the iliac bed, blood flow was reduced and resistance was actually increased by 33 +/- 11% above control. A generalized vasonconstriction ensued after cessation of infusion. In contrast, when the drug was administered intra- arterially to the iliac bed, arterial pressure did not fall and only iliac vasodilation was observed. Peak cardiac effects were characterized by increases in heart rate and LV dP/dt, along with marked reduction in LV end-systolic diameter (- 13 +/- 2%), and in end- diastolic diameter (-17 +/- 2%) and pressure. LV end-diastolic diameter fell even heart rate was maintained at a constant rate by pacing. Thus, in the conscious dog, NP reduced LV dimensions substantially, while inducing changes in peripheral beds. The differences in these effects depend on interactions between the direct effects of NP and the opposing effects of reflex adjustments which appear sufficiently powerful to result in net constriction of the iliac bed late during the infusion.

This article has been cited by other articles:

				N. F. Rossi, D. S. O'Leary, D. Woodbury, and H. Chen Endothelin-1 in hypertension in the baroreflex-intact SHR: a role independent from vasopressin release Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E18 - E24. [Abstract] [Full Text] [PDF]

				S. C. TEXTOR, A. C. NOVICK, R. C. TARAZI, V. KLIMAS, D. G. VIDT, and M. POHL Critical Perfusion Pressure for Renal Function in Patients with Bilateral Atherosclerotic Renal Vascular Disease Ann Intern Med, March 1, 1985; 102(3): 308 - 314. [Abstract] [PDF]

				L. Dumont, C. Lamoureux, J. Lelorier, P. Stanley, and C. Chartrand Hypotension and Arteriovenous Shunting: Effects of Intravenous Infusion of Nitroprusside, Nitroglycerin and Phentolamine Angiology, February 1, 1984; 35(2): 88 - 96. [Abstract] [PDF]

				S. C. Textor, A. C. Novick, D. R. Steinmuller, and S. B. Streem Renal Failure Limiting Antihypertensive Therapy as an Indication for Renal Revascularization: A Case Report Arch Intern Med, November 1, 1983; 143(11): 2208 - 2211. [Abstract] [PDF]

				R. C. Hill, W. R. Chitwood Jr, J. D. Sink, J. L. Cox, and A. S. Wechsler Perioperative Assessment of Segmental Left Ventricular Function in Man: Effects of Nitroprusside After Bypass Operations Arch Surg, May 1, 1980; 115(5): 609 - 614. [Abstract] [PDF]