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Circulation, Vol 65, 1025-1029, Copyright © 1982 by American Heart Association

ARTICLES

The potentiation of warfarin anticoagulation by amiodarone

A Hamer, T Peter, WJ Mandel, MM Scheinman and D Weiss

The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.

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