| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Circulation, Vol 69, 203-213, Copyright © 1984 by American Heart Association
RJ Rodeheffer, G Gerstenblith, LC Becker, JL Fleg, ML Weisfeldt and EG Lakatta
To assess the effect of age on cardiac volumes and function in the absence
of overt or occult coronary disease, we performed serial gated blood pool
scans at rest and during progressive upright bicycle exercise to exhaustion
in 61 participants in the Baltimore Longitudinal Study of Aging. The
subjects ranged in age from 25 to 79 years and were free of cardiac disease
according to their histories and results of physical, resting and stress
electrocardiographic, and stress thallium scintigraphic examinations.
Absolute left ventricular volumes were obtained at each workload. There
were no age-related changes in cardiac output, end-diastolic or
end-systolic volumes, or ejection fraction at rest. During vigorous
exercise (125 W), cardiac output was not related to age (cardiac output
[1/min] = 16.02 + 0.03 [age]; r = .12, p = .46). However, there was an
age-related increase in end-diastolic volume (end- diastolic volume [ml] =
86.30 + 1.48 [age]; r = .47, p = .003) and stroke volume (stroke volume
[ml] = 85.52 + 0.80 [age]; r = .37, p = .02), and an age-related decrease
in heart rate (heart rate [beats/min] = 184.66 - 0.70 [age]; r = -.50, p =
.002). The dependence of the age- related increase in stroke volume on
diastolic filling was emphasized by the fact that at this high workload
end-systolic volume was higher (end-systolic volume [ml] = 3.09 + 0.65
[age]; r = .45, p = .003) and ejection fraction lower (ejection fraction =
88.48 - 0.18 [age]; r = - .33, p = .04) with increasing age. These findings
indicate that although aging does not limit cardiac output per se in
healthy community-dwelling subjects, the hemodynamic profile accompanying
exercise is altered by age and can be explained by an age-related
diminution in the cardiovascular response to beta-adrenergic stimulation.
ARTICLES
Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate
This article has been cited by other articles:
 |
|
 |
|
  H. Tanaka and D. R. Seals Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms J. Physiol., January 1, 2008; 586(1): 55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Jegger, R. F. da Silva, I. Lartaud, V. Gaillard, X. Jeanrenaud, M. Nasratullah, L. K. von Segesser, J. Atkinson, P. Segers, H. Tevaearai, et al. Effects of an aging vascular model on healthy and diseased hearts Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1334 - H1343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Borlaug, V. Melenovsky, S. D. Russell, K. Kessler, K. Pacak, L. C. Becker, and D. A. Kass Impaired Chronotropic and Vasodilator Reserves Limit Exercise Capacity in Patients With Heart Failure and a Preserved Ejection Fraction Circulation, November 14, 2006; 114(20): 2138 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Weiss, R. J. Spina, J. O. Holloszy, and A. A. Ehsani Gender differences in the decline in aerobic capacity and its physiological determinants during the later decades of life J Appl Physiol, September 1, 2006; 101(3): 938 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Deschenes, J. A. Carter, E. N. Matney, M. B. Potter, and M. H. Wilson Aged Men Experience Disturbances in Recovery Following Submaximal Exercise J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2006; 61(1): 63 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Eklund, K. S. Hageman, D. C. Poole, and T. I. Musch Impact of aging on muscle blood flow in chronic heart failure J Appl Physiol, August 1, 2005; 99(2): 505 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Brondel, F. Mourey, C. Mischis-Troussard, P. d'Athis, and P. Pfitzenmeyer Energy Cost and Cardiorespiratory Adaptation in the "Get-Up-and-Go" Test in Frail Elderly Women With Postural Abnormalities and in Controls J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2005; 60(1): 98 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lai, A. Kaykha, T. Yamazaki, M. Goldstein, J. M. Spin, J. Myers, and V. F. Froelicher Treadmill scores in elderly men J. Am. Coll. Cardiol., February 18, 2004; 43(4): 606 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. U. Ferrari, A. Radaelli, and M. Centola Invited Review: Aging and the cardiovascular system J Appl Physiol, December 1, 2003; 95(6): 2591 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Peterson, M. R. Rinder, K. B. Schechtman, R. J. Spina, K. L. Glover, D. T. Villareal, and A. A. Ehsani Peak exercise stroke volume: associations with cardiac structure and diastolic function J Appl Physiol, March 1, 2003; 94(3): 1108 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. L. Correia, E. G. Lakatta, F. C. O'Connor, L. C. Becker, J. Clulow, S. Townsend, G. Gerstenblith, and J. L. Fleg Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1290 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. McGuire, B. D. Levine, J. W. Williamson, P. G. Snell, C. G. Blomqvist, B. Saltin, and J. H. Mitchell A 30-Year Follow-Up of the Dallas Bed Rest and Training Study: I. Effect of Age on the Cardiovascular Response to Exercise Circulation, September 18, 2001; 104(12): 1350 - 1357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. McGuire, B. D. Levine, J. W. Williamson, P. G. Snell, C. G. Blomqvist, B. Saltin, and J. H. Mitchell A 30-Year Follow-Up of the Dallas Bed Rest and Training Study: II. Effect of Age on Cardiovascular Adaptation to Exercise Training Circulation, September 18, 2001; 104(12): 1358 - 1366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Kolh, A Kerzmann, L Lahaye, P Gerard, and R Limet Cardiac surgery in octogenarians. Peri-operative outcome and long-term results Eur. Heart J., July 2, 2001; 22(14): 1235 - 1243. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Sehl and F. E. Yates Kinetics of Human Aging: I. Rates of Senescence Between Ages 30 and 70 Years in Healthy People J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2001; 56(5): 198B - 208. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. J. Zieman, G. Gerstenblith, E. G. Lakatta, G. O. Rosas, K. Vandegaer, K. M. Ricker, and J. M. Hare Upregulation of the Nitric Oxide-cGMP Pathway in Aged Myocardium : Physiological Response to l-Arginine Circ. Res., January 19, 2001; 88(1): 97 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Higbee The Geriatric Patient: General Physiologic and Pharmacologic Considerations Journal of Pharmacy Practice, August 1, 2000; 13(4): 250 - 262. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Y. Goraya, S. J. Jacobsen, P. A. Pellikka, T. D. Miller, A. Khan, S. A. Weston, B. J. Gersh, and V. L. Roger Prognostic Value of Treadmill Exercise Testing in Elderly Persons Ann Intern Med, June 6, 2000; 132(11): 862 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Elhendy, R. T. van Domburg, J. J. Bax, R. Valkema, A. E. M. Reijs, E. P. Krenning, and J. R. T. C. Roelandt Safety, Hemodynamic Profile, and Feasibility of Dobutamine Stress Technetium Myocardial Perfusion Single-Photon Emission CT Imaging for Evaluation of Coronary Artery Disease in the Elderly Chest, March 1, 2000; 117(3): 649 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O.-E. Brodde and M. C. Michel Adrenergic and Muscarinic Receptors in the Human Heart Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nussbacher, G. Gerstenblith, F. C. O'connor, L. C. Becker, D. A. Kass, S. P. Schulman, J. L. Fleg, and E. G. Lakatta Hemodynamic effects of unloading the old heart Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1863 - H1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Seals, E. T. Stevenson, P. P. Jones, C. A. DeSouza, and H. Tanaka Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H947 - H955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Dinenno, P. P. Jones, D. R. Seals, and H. Tanaka Limb Blood Flow and Vascular Conductance Are Reduced With Age in Healthy Humans : Relation to Elevations in Sympathetic Nerve Activity and Declines in Oxygen Demand Circulation, July 13, 1999; 100(2): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Chen, M. Nakayama, E. Nevo, B. J. Fetics, W. L. Maughan, and D. A. Kass Coupled systolic-ventricular and vascular stiffening with age: Implications for pressure regulation and cardiac reserve in the elderly J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1221 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R. Asbahr, A. B. Negrão, V. Gentil, D. M.T. Zanetta, J. A. da Paz, M. J. Marques-Dias, and M. H. Kiss Obsessive-Compulsive and Related Symptoms in Children and Adolescents With Rheumatic Fever With and Without Chorea: A Prospective 6-Month Study Am J Psychiatry, August 1, 1998; 155(8): 1122 - 1124. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Heymes, J.-S. Silvestre, C. Llorens-Cortes, F. Marotte, B. Chevalier, B. I. Levy, B. Swynghedauw, and J.-L. Samuel Cardiac Senescence Is Associated with Enhanced Expression of Angiotensin II Receptor Subtypes Endocrinology, May 1, 1998; 139(5): 2579 - 2587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Pickering, N. Fellmann, B. Morio, P. Ritz, A. Amonchot, M. Vermorel, and J. Coudert Effects of endurance training on the cardiovascular system and water compartments in elderly subjects J Appl Physiol, October 1, 1997; 83(4): 1300 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Prendergast, B M. Sci, V. F. Sagach, and A. M. Shah Basal Release of Nitric Oxide Augments the Frank-Starling Response in the Isolated Heart Circulation, August 19, 1997; 96(4): 1320 - 1329. [Abstract] [Full Text]
|
|
|
|
|
|
H. Bueno, R. Lopez-Palop, J. Bermejo, J. L. Lopez-Sendon, and J. L. Delcan In-Hospital Outcome of Elderly Patients With Acute Inferior Myocardial Infarction and Right Ventricular Involvement Circulation, July 15, 1997; 96(2): 436 - 441. [Abstract] [Full Text]
|
|
|
|
|
|
P.-O. Astrand, U. Bergh, and A. Kilbom A 33-yr follow-up of peak oxygen uptake and related variables of former physical education students J Appl Physiol, June 1, 1997; 82(6): 1844 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamakado, E. Takagi, S. Okubo, K. Imanaka-Yoshida, T. Tarumi, M. Nakamura, and T. Nakano Effects of Aging on Left Ventricular Relaxation in Humans: Analysis of Left Ventricular Isovolumic Pressure Decay Circulation, February 18, 1997; 95(4): 917 - 923. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Assayag, D. Charlemagne, J. de Leiris, F. Boucher, P.-E. Valere, S. Lortet, B. Swynghedauw, and S. Besse Senescent Heart Compared With Pressure Overload-Induced Hypertrophy Hypertension, January 1, 1997; 29(1): 15 - 21. [Abstract] [Full Text]
|
|