Circulation, Vol 70, 724-733, Copyright © 1984 by American Heart Association
SR Bergmann, KA Fox, AL Rand, KD McElvany, MJ Welch, J Markham and BE Sobel
Using H215O (half-life = 2.1 min) we demonstrated that a modification of
the tissue autoradiographic approach permitted quantitation of myocardial
blood flow in open-chest dogs by direct assay of myocardial tissue and that
noninvasive estimation with positron-emission tomography (PET) delineated
relative myocardial blood flow in intact dogs. In open-chest anesthetized
dogs, the single-pass extraction fraction of H215O averaged 96 +/- 5% at
flows of 80 to 100 ml/100 g/min. This high extraction fraction did not
differ significantly over the range of 12 to 238 ml/100 g/min. Myocardial
blood flow calculated after a 60 sec intravenous infusion of H215O and
direct analysis of tissue correlated well with results obtained with
microspheres (r = .94, n = 9 dogs). Subsequently the approach was adapted
for preliminary use with PET. Estimation of myocardial content of
radiolabeled H2O after intravenous infusion of 20 to 30 mCi of H215O was
corrected for vascular pool radioactivity with the use of tomographic data
obtained after administration of C15O by inhalation to label red blood
cells. Tomograms obtained in vivo in six dogs with either normal or reduced
regional blood flow correlated closely with the tomographically detectable
distribution of 68Ga-labeled microspheres (r = .93) and with postmortem
microsphere distribution (r = .95). The technique accurately reflects
myocardial blood flow. With the use of PET, rapid sequential noninvasive
estimation of relative regional myocardial blood flow has been demonstrated
that should ultimately permit improved objective assessment of nutritional
blood flow in patients in response to medical and surgical interventions
designed to augment perfusion.
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Quantification of regional myocardial blood flow in vivo with H215O
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