Circulation, Vol 70, 806-811, Copyright © 1984 by American Heart Association
UK Franzeck, A Bollinger, R Huch and A Huch
The transparent oxygen electrode, recently developed by Huch and his co-
workers, permits monitoring of transcutaneous oxygen tension (tcPO2) at
defined sites on the capillaroscopic image obtained by videomicroscopy.
This combined system has been applied to study the nutritional skin
capillaries of patients with chronic venous incompetence (CVI). The results
of 44 studies in 17 patients with CVI demonstrated a direct correlation
between tcPO2 and density and morphologic characteristics of the
superficial capillaries. The mean tcPO2 was 47.7 +/- 14.4 mm Hg at the site
of incompetent perforating veins of the ankle without major trophic
changes. There was no statistically significant difference between the mean
values obtained in patients and control subjects (56.8 +/- 9.9 mm Hg).
Videomicroscopic examination revealed dilated and tortuous capillaries
surrounded by halo formations. In areas of hyperpigmentation, induration,
and hyperkeratosis, significantly decreased mean tcPO2 (22.5 +/- 7.0 mm Hg;
p less than .001) corresponded to reduced capillary density (less than 10
capillaries/mm2). In avascular skin areas (scar tissue, white atrophy)
tcPO2 was measured at 0 mm Hg. No capillaries, or a greatly reduced number,
were visible at such sites, resulting in a distance between capillary and
cathode tip of the oxygen sensor of greater than 100 micron. The combined
system of tcPO2 measurement and simultaneous videomicroscopy gives new
pathophysiologic information on the development of skin ulcers and may be
useful for the objective comparison of different therapeutic modalities at
the microcirculatory level.
ARTICLES
Transcutaneous oxygen tension and capillary morphologic characteristics and density in patients with chronic venous incompetence
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