Circulation, Vol 74, 81-88, Copyright © 1986 by American Heart Association
P Camici, LI Araujo, T Spinks, AA Lammertsma, JC Kaski, MJ Shea, AP Selwyn, T Jones and A Maseri
Regional myocardial perfusion and exogenous glucose uptake were assessed
with rubidium-82 (82Rb) and 18F-2-fluoro-2-deoxyglucose (FDG) in 10 normal
volunteers and 12 patients with coronary artery disease and stable angina
pectoris by means of positron emission tomography. In patients at rest, the
myocardial uptake of 82Rb and FDG did not differ significantly from that
measured in normal subjects. The exercise test performed within the
positron camera in eight patients produced typical chest pain and ischemic
electrocardiographic changes in all. In each of the eight patients a region
of reduced cation uptake was demonstrated in the 82Rb scan recorded at peak
exercise, after which uptake of 82Rb returned to the control value 5 to 14
min after the end of the exercise. In these patients, FDG was injected in
the recovery phase when all the variables that were altered during
exercise, including regional myocardial 82Rb uptake, had returned to
control values. In all but one patient, FDG accumulation in the regions of
reduced 82Rb uptake during exercise was significantly higher than that in
the nonischemic regions, i.e., the ones with a normal increment of 82Rb
uptake on exercise. In the nonischemic areas, FDG uptake was not
significantly different from that found in normal subjects after exercise.
In conclusion, myocardial glucose transport and phosphorylation seem to be
enhanced in the postischemic myocardium of patients with exercise- induced
ischemia.
ARTICLES
Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina
This article has been cited by other articles:
 |
|
 |
|
  C. M. Prado, E. J. Fine, W. Koba, D. Zhao, M. A. Rossi, H. B. Tanowitz, and L. A. Jelicks Micro-Positron Emission Tomography in the Evaluation of Trypanosoma cruzi-Induced Heart Disease: Comparison with Other Modalities Am J Trop Med Hyg, November 1, 2009; 81(5): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 CardioPulse Articles Eur. Heart J., August 2, 2009; 30(16): 1927 - 1935. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Crea, P. G. Camici, R. De Caterina, and G. A. Lanza CHAPTER 17 Chronic Ischaemic Heart Disease ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Dilsizian 18F-FDG Uptake as a Surrogate Marker for Antecedent Ischemia J. Nucl. Med., December 1, 2008; 49(12): 1909 - 1911. [Full Text] [PDF]
|
|
|
|
|
|
K.-F. Dou, M.-F. Yang, Y.-J. Yang, D. Jain, and Z.-X. He Myocardial 18F-FDG Uptake After Exercise-Induced Myocardial Ischemia in Patients with Coronary Artery Disease J. Nucl. Med., December 1, 2008; 49(12): 1986 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J.W. Chow, R. S. Beanlands, A. Lee, J. N. DaSilva, R. A. deKemp, A. Alkahtani, and T. D. Ruddy Treadmill Exercise Produces Larger Perfusion Defects Than Dipyridamole Stress N-13 Ammonia Positron Emission Tomography J. Am. Coll. Cardiol., January 17, 2006; 47(2): 411 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Stegger, K. P. Schafers, U. Flogel, L. Livieratos, S. Hermann, C. Jacoby, P. Keul, E. M. Conway, O. Schober, J. Schrader, et al. Monitoring Left Ventricular Dilation in Mice with PET J. Nucl. Med., September 1, 2005; 46(9): 1516 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J.W. Chow, K. Ananthasubramaniam, R. A. deKemp, M. M. Dalipaj, R. S.B. Beanlands, and T. D. Ruddy Comparison of treadmill exercise versus dipyridamole stress with myocardial perfusion imaging using rubidium-82 positron emission tomography J. Am. Coll. Cardiol., April 19, 2005; 45(8): 1227 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-X. He, R.-F. Shi, Y.-J. Wu, Y.-Q. Tian, X.-J. Liu, S.-W. Wang, R. Shen, X.-W. Qin, R.-L. Gao, J. Narula, et al. Direct Imaging of Exercise-Induced Myocardial Ischemia With Fluorine-18-Labeled Deoxyglucose and Tc-99m-Sestamibi in Coronary Artery Disease Circulation, September 9, 2003; 108(10): 1208 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. I.W. Galasko and A. Lahiri The non-invasive assessment of hibernating myocardium in ischaemic cardiomyopathy--a myriad of techniques Eur J Heart Fail, June 1, 2003; 5(3): 217 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. McFalls, B. Murad, D. Her, J.-S. Liow, R. Kelly, D. Marx, J. Sikora, and H. B. Ward Repetitive Supply-Demand Ischemia with Dobutamine Increases Glucose Uptake in Postischemic and Remote Myocardium J. Nucl. Med., January 1, 2003; 44(1): 85 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Gerber, S. Laycock, J. A. Melin, M. Borgers, W. Flameng, and J.-L. J. Vanoverschelde Myocardial Blood Flow, Metabolism, and Inotropic Reserve in Dogs with Dysfunctional Noninfarcted Collateral-Dependent Myocardium J. Nucl. Med., April 1, 2002; 43(4): 556 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Camici and D. P. Dutka Repetitive stunning, hibernation, and heart failure: contribution of PET to establishing a link Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H929 - H936. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fallavollita, C. Trojan, and J. M. Canty Jr. Transmural distribution of FDG uptake in stunned myocardium Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H102 - H109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E Barnes, C S R Baker, D P Dutka, O Rimoldi, C A Rinaldi, P Nihoyannopoulos, P G Camici, and R J C Hall Prolonged left ventricular dysfunction occurs in patients with coronary artery disease after both dobutamine and exercise induced myocardial ischaemia Heart, March 1, 2000; 83(3): 283 - 289. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Fallavollita and J. M. Canty Jr Differential 18F-2-Deoxyglucose Uptake in Viable Dysfunctional Myocardium With Normal Resting Perfusion : Evidence for Chronic Stunning in Pigs Circulation, June 1, 1999; 99(21): 2798 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Paternostro, D. Pagano, T. Gnecchi-Ruscone, R. S Bonser, and P. G Camici Insulin resistance in patients with cardiac hypertrophy Cardiovasc Res, April 1, 1999; 42(1): 246 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Udelson Steps Forward in the Assessment of Myocardial Viability in Left Ventricular Dysfunction Circulation, March 10, 1998; 97(9): 833 - 838. [Full Text] [PDF]
|
|
|
|
|
|
S. Egert, N. Nguyen, F. C Brosius III, and M. Schwaiger Effects of wortmannin on insulin- and ischemia-induced stimulation of GLUT4 translocation and FDG uptake in perfused rat hearts Cardiovasc Res, August 1, 1997; 35(2): 283 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fallavollita, B. J. Perry, and J. M. Canty Jr 18F-2-Deoxyglucose Deposition and Regional Flow in Pigs With Chronically Dysfunctional Myocardium : Evidence for Transmural Variations in Chronic Hibernating Myocardium Circulation, April 1, 1997; 95(7): 1900 - 1909. [Abstract] [Full Text]
|
|
|
|
|
|
G. Ambrosio, S. Betocchi, L. Pace, M. A. Losi, P. Perrone-Filardi, A. Soricelli, F. Piscione, J. Taube, F. Squame, M. Salvatore, et al. Prolonged Impairment of Regional Contractile Function After Resolution of Exercise-Induced Angina: Evidence of Myocardial Stunning in Patients With Coronary Artery Disease Circulation, November 15, 1996; 94(10): 2455 - 2464. [Abstract] [Full Text]
|
|
|
|
|
|
J. vom Dahl, O. Muzik, E. R. Wolfe Jr, C. Allman, G. Hutchins, and M. Schwaiger Myocardial Rubidium-82 Tissue Kinetics Assessed by Dynamic Positron Emission Tomography as a Marker of Myocardial Cell Membrane Integrity and Viability Circulation, January 15, 1996; 93(2): 238 - 245. [Abstract] [Full Text]
|
|
|
|
 |
|
 Council on Scientific Affairs Report of the Positr, G. M. Bohigian, E. H. Estes Jr, I. R. Friedlander, W. R. Kennedy, J. H. Moxley III, P. Numann, P. S. Salva, W. C. Scott, J. H. Skom, et al. Application of Positron Emission Tomography in the Heart JAMA, April 22, 1988; 259(16): 2438 - 2445. [Abstract] [PDF]
|
|
|
|
 |
|
 B. PATEL, R. A. KLONER, K. PRZYKLENK, and E. BRAUNWALD Postischemic Myocardial "Stunning": A Clinically Relevant Phenomenon Ann Intern Med, April 1, 1988; 108(4): 626 - 628. [Abstract] [PDF]
|
|