This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fujita, T. Articles by Sato, Y. Search for Related Content PubMed PubMed Citation Articles by Fujita, T. Articles by Sato, Y.

Circulation, Vol 75, 525-532, Copyright © 1987 by American Heart Association

ARTICLES

Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension

T Fujita, K Ando, H Noda, Y Ito and Y Sato

Recent studies showed that taurine, a sulphonic amino acid, could decrease blood pressure and increase sympathoadrenal tone in DoCA-salt- treated hypertensive rats. To determine whether taurine exerts its antihypertensive action in man in a similar fashion, we studied the effect of oral administration of taurine (6 g for 7 days) on blood pressure and plasma catecholamines in 19 young patients with borderline hypertension in a double-blind, placebo-controlled fashion. Systolic blood pressure in the 10 patients who were treated with taurine decreased by 9.0 +/- 2.9 mm Hg (mean +/- SE; p less than .05 by paired t test), compared with a 2.7 +/- 2.3 mm Hg decrease (NS) in the nine patients treated with placebo and diastolic blood pressure in the taurine-treated patients decreased by 4.1 +/- 1.7 mm Hg (p less than .05) compared with 1.2 +/- 3.0 mm Hg (NS) in the placebo-treated subjects. In the patients receiving taurine plasma epinephrine (E) decreased significantly, with a negligible decrease in plasma norepinephrine (NE). The effect of taurine on plasma catecholamines and the response of plasma E after the stimulation with glucagon was also studied in 12 borderline hypertensive and nine age-matched normotensive subjects. Basal plasma E was significantly higher in borderline hypertensive than in normal subjects, but basal plasma NE did not differ in the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				M. Umesawa, S. Sato, H. Imano, A. Kitamura, T. Shimamoto, K. Yamagishi, T. Tanigawa, and H. Iso Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS) Am. J. Clinical Nutrition, August 1, 2009; 90(2): 377 - 384. [Abstract] [Full Text] [PDF]

				L. Steinke, D. E Lanfear, V. Dhanapal, and J. S Kalus Effect of "Energy Drink" Consumption on Hemodynamic and Electrocardiographic Parameters in Healthy Young Adults Ann. Pharmacother., April 1, 2009; 43(4): 596 - 602. [Abstract] [Full Text] [PDF]