Circulation, Vol 80, 146-157, Copyright © 1989 by American Heart Association
GE Billman and RS Hoskins
Periodic fluctuations in the R-R interval have been used as noninvasive
measures of cardiac autonomic tone. For example, a reduced heart rate
variability has been shown to correlate with an increased mortality in
patients recovering from myocardial infarction. The effects that
physiologic perturbations such as exercise have on this heart rate
variability have not been investigated. Therefore, heart rate variability
was measured throughout a submaximal exercise test in 36 mongrel dogs with
healed anterior myocardial infarctions. The amplitude of the respiratory
component (0.24-1.04 Hz) was determined by time- series analysis techniques
and was used as an index of cardiac vagal tone. On a subsequent day, a
2-minute coronary occlusion was initiated during the last minute of
exercise. Twenty-two animals developed ventricular fibrillation
(susceptible), whereas 14 animals did not (resistant). Exercise elicited a
significantly greater increase in heart rate (resistant, 205.4 +/- 7.1;
susceptible, 227.0 +/- 5.4 beats/min) in susceptible animals, which was
accompanied by a greater reduction in the cardiac vagal tone index
(resistant, 2.7 +/- 0.3; susceptible, 1.1 +/- 0.2 ln msec2) as compared
with resistant animals. Conversely, atropine sulfate (50 micrograms/kg)
given during exercise elicited a greater heart rate increase in the
resistant dogs (heart rate change: resistant, 54.2 +/- 7.0; susceptible,
18.7 +/- 4.4 beats/min). Taken together, these data suggest that exercise
elicited a greater reduction in cardiac vagal tone in animals known to be
susceptible to ventricular fibrillation.
ARTICLES
Time-series analysis of heart rate variability during submaximal exercise. Evidence for reduced cardiac vagal tone in animals susceptible to ventricular fibrillation
Department of Physiology, Ohio State University, Columbus 43210.
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