Circulation, Vol 89, 122-131, Copyright © 1994 by American Heart Association
LC Palmon, N Reichek, SB Yeon, NR Clark, D Brownson, E Hoffman and L Axel
BACKGROUND: In hypertensive left ventricular hypertrophy (LVH), intrinsic
myocardial systolic function may be normal or depressed. Magnetic resonance
tagging can depict intramural myocardial shortening in vivo. METHODS AND
RESULTS: Tagged left ventricular magnetic resonance images were obtained in
30 hypertensive subjects with LVH (mean LV mass index, 142 +/- 41 g/m) and
normal ejection fraction (mean, 64 +/- 9%) using spatial modulation of
magnetization. In 26 subjects, circumferential myocardial shortening (%S)
was compared with results obtained in 10 normal subjects at endocardium,
midwall, and epicardium on up to 4 short-axis slices each. Similarly, in 10
subjects, midwall long-axis shortening at basal, midventricular, and apical
sites was compared with results obtained in 12 normal volunteers.
Circumferential %S was reduced in hypertensive subjects. Mean shortening
was 29 +/- 6% at the endocardium in hypertensive subjects versus 44 +/- 6%
in normal subjects (P = .0001); 20 +/- 6% at the midwall versus 30 +/- 6%
(P = .0001); and 13 +/- 5% at the epicardium versus 21 +/- 5% (P = .0002).
However, the transmural gradient in percent shortening from endocardium to
epicardium in hypertensive subjects paralleled that in normal subjects. The
normal base-to-apex gradient in circumferential %S was absent in LVH. In
contrast to normal subjects, circumferential %S showed regional
heterogeneity in hypertensive subjects, being maximal in the lateral wall
and least in the inferior wall. Longitudinal shortening was also uniformly
depressed in hypertensive subjects: 10 +/- 9% at the base versus 21 +/- 6%
in normal subjects (P = .0001); 14 +/- 8% at the midventricle versus 18 +/-
3% (P = .03); and 14 +/- 8% at the apex versus 18 +/- 4% (P = .04).
CONCLUSIONS: In hypertensive LVH with normal pump function, intramural
circumferential and longitudinal myocardial shortening are depressed.
ARTICLES
Intramural myocardial shortening in hypertensive left ventricular hypertrophy with normal pump function
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia.
This article has been cited by other articles:
 |
|
 |
|
  E. Donal, C. Bergerot, H. Thibault, L. Ernande, J. Loufoua, L. Augeul, M. Ovize, and G. Derumeaux Influence of afterload on left ventricular radial and longitudinal systolic functions: a two-dimensional strain imaging study Eur J Echocardiogr, December 1, 2009; 10(8): 914 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Narayanan, G. P. Aurigemma, M. Chinali, J. C. Hill, T. E. Meyer, and D. A. Tighe Cardiac Mechanics in Mild Hypertensive Heart Disease: A Speckle-Strain Imaging Study Circ Cardiovasc Imaging, September 1, 2009; 2(5): 382 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kuznetsova, L. Herbots, T. Richart, J. D'hooge, L. Thijs, R. H. Fagard, M.-C. Herregods, and J. A. Staessen Left ventricular strain and strain rate in a general population Eur. Heart J., August 2, 2008; 29(16): 2014 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W.W. Biederman, M. Doyle, A. A. Young, R. B. Devereux, E. Kortright, G. Perry, J. N. Bella, S. Oparil, D. Calhoun, G. M. Pohost, et al. Marked Regional Left Ventricular Heterogeneity in Hypertensive Left Ventricular Hypertrophy Patients: A Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Cardiovascular Magnetic Resonance and Echocardiographic Substudy Hypertension, August 1, 2008; 52(2): 279 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baltabaeva, M. Marciniak, B. Bijnens, J. Moggridge, F. J. He, T. F. Antonios, G. A. MacGregor, and G. R. Sutherland Regional left ventricular deformation and geometry analysis provides insights in myocardial remodelling in mild to moderate hypertension Eur J Echocardiogr, July 1, 2008; 9(4): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ganame, L. Mertens, B. W. Eidem, P. Claus, J. D'hooge, L. M. Havemann, C. J. McMahon, M. A. A. Elayda, W. K. Vaughn, J. A. Towbin, et al. Regional myocardial deformation in children with hypertrophic cardiomyopathy: morphological and clinical correlations Eur. Heart J., December 1, 2007; 28(23): 2886 - 2894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ring, H. Persson, M. Mejhert, and M. Edner Post-systolic motion in patients with heart failure - A marker of left ventricular dyssynchrony? Eur J Echocardiogr, October 1, 2007; 8(5): 352 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Perseghin, G. Ntali, F. De Cobelli, G. Lattuada, A. Esposito, E. Belloni, T. Canu, F. Costantino, F. Ragogna, P. Scifo, et al. Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With Insulin Resistance Diabetes Care, June 1, 2007; 30(6): 1520 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. Rosen, M. F. Saad, S. Shea, K. Nasir, T. Edvardsen, G. Burke, M. Jerosch-Herold, D. K. Arnett, S. Lai, D. A. Bluemke, et al. Hypertension and Smoking Are Associated With Reduced Regional Left Ventricular Function in Asymptomatic Individuals: The Multi-Ethnic Study of Atherosclerosis J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1150 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Reichek The Multi-Ethnic Study of Atherosclerosis (MESA) and Myocardial Function: Where Is the Boundary Between Risk Factor and Disease? J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1159 - 1160. [Full Text] [PDF]
|
|
|
|
 |
|
 G. P. Aurigemma, M. R. Zile, and W. H. Gaasch Contractile Behavior of the Left Ventricle in Diastolic Heart Failure: With Emphasis on Regional Systolic Function Circulation, January 17, 2006; 113(2): 296 - 304. [Full Text] [PDF]
|
|
|
|
|
|
M.W. Ashford Jr, W. Liu, S.J. Lin, P. Abraszewski, S.D. Caruthers, A.M. Connolly, X. Yu, and S.A. Wickline Occult Cardiac Contractile Dysfunction in Dystrophin-Deficient Children Revealed by Cardiac Magnetic Resonance Strain Imaging Circulation, October 18, 2005; 112(16): 2462 - 2467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Rosen, T. Edvardsen, S. Lai, E. Castillo, L. Pan, M. Jerosch-Herold, S. Sinha, R. Kronmal, D. Arnett, J. R. Crouse III, et al. Left Ventricular Concentric Remodeling Is Associated With Decreased Global and Regional Systolic Function: The Multi-Ethnic Study of Atherosclerosis Circulation, August 16, 2005; 112(7): 984 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Amano, S. Kumita, M. Takayama, and T. Kumazaki Comparison of Contrast-Enhanced MRI with Iodine-123 BMIPP for Detection of Myocardial Damage in Hypertrophic Cardiomyopathy Am. J. Roentgenol., August 1, 2005; 185(2): 312 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Smiseth and H. Ihlen Strain rate imaging: why do we need it? J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1584 - 1586. [Full Text] [PDF]
|
|
|
|
|
|
D. L. King, L. El-Khoury Coffin, and M. S. Maurer Myocardial contraction fraction: a volumetric index of myocardial shortening by freehand three-dimensional echocardiography J. Am. Coll. Cardiol., July 17, 2002; 40(2): 325 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Yeon, N. Reichek, B. A. Tallant, J. A. C. Lima, L. P. Calhoun, N. R. Clark, E. A. Hoffman, K. K. L. Ho, and L. Axel Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry J. Am. Coll. Cardiol., August 1, 2001; 38(2): 555 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Perlini, M. L. Muiesan, C. Cuspidi, L. Sampieri, B. Trimarco, G. P. Aurigemma, E. Agabiti-Rosei, and G. Mancia Midwall Mechanics Are Improved After Regression of Hypertensive Left Ventricular Hypertrophy and Normalization of Chamber Geometry Circulation, February 6, 2001; 103(5): 678 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Young, S. Dokos, K. A. Powell, B. Sturm, A. D. McCulloch, R. C. Starling, P. M. McCarthy, and R. D. White Regional heterogeneity of function in nonischemic dilated cardiomyopathy Cardiovasc Res, February 1, 2001; 49(2): 308 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Duru, R Luechinger, M.B Scheidegger, T.F Luscher, P Boesiger, and R Candinas Pacing in magnetic resonance imaging environment: Clinical and technical considerations on compatibility Eur. Heart J., January 2, 2001; 22(2): 113 - 124. [PDF]
|
|
|
|
|
|
J. Mayet, B. Ariff, B. Wasan, N. Chapman, M. Shahi, N. R. Poulter, P. S. Sever, R. A. Foale, and S. A. McG. Thom Improvement in Midwall Myocardial Shortening With Regression of Left Ventricular Hypertrophy Hypertension, November 1, 2000; 36(5): 755 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Moore, C. H. Lugo-Olivieri, E. R. McVeigh, and E. A. Zerhouni Three-dimensional Systolic Strain Patterns in the Normal Human Left Ventricle: Characterization with Tagged MR Imaging Radiology, February 1, 2000; 214(2): 453 - 466. [Abstract] [Full Text]
|
|
|
|
|
|
B. M. Pluim, A. H. Zwinderman, A. van der Laarse, and E. E. van der Wall The Athlete’s Heart : A Meta-Analysis of Cardiac Structure and Function Circulation, January 25, 2000; 101(3): 336 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-S. Tea, T.-V. Dam, P. Moreau, P. Hamet, and D. deBlois Apoptosis During Regression of Cardiac Hypertrophy in Spontaneously Hypertensive Rats : Temporal Regulation and Spatial Heterogeneity Hypertension, August 1, 1999; 34(2): 229 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Costa, Y. Takayama, A. D. McCulloch, and J. W. Covell Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H595 - H607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Sadler, G. P. Aurigemma, D. W. Williams, D. J. Reda, B. J. Materson, and J. S. Gottdiener Systolic Function in Hypertensive Men With Concentric Remodeling Hypertension, October 1, 1997; 30(4): 777 - 781. [Abstract] [Full Text]
|
|
|
|
|
|
G. A. MacGowan, E. P. Shapiro, H. Azhari, C. O. Siu, P. S. Hees, G. M. Hutchins, J. L. Weiss, and F. E. Rademakers Noninvasive Measurement of Shortening in the Fiber and Cross-Fiber Directions in the Normal Human Left Ventricle and in Idiopathic Dilated Cardiomyopathy Circulation, July 15, 1997; 96(2): 535 - 541. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Kramer, W. J. Rogers, T. M. Theobald, T. P. Power, S. Petruolo, and N. Reichek Remote Noninfarcted Region Dysfunction Soon After First Anterior Myocardial Infarction: A Magnetic Resonance Tagging Study Circulation, August 15, 1996; 94(4): 660 - 666. [Abstract] [Full Text]
|
|
|
|
|
|
S.-J. Dong, A. P. Crawley, J. H. MacGregor, Y. F. Petrank, D. W. Bergman, I. Belenkie, E. R. Smith, J. V. Tyberg, and R. Beyar Regional Left Ventricular Systolic Function in Relation to the Cavity Geometry in Patients With Chronic Right Ventricular Pressure Overload : A Three-Dimensional Tagged Magnetic Resonance Imaging Study Circulation, May 1, 1995; 91(9): 2359 - 2370. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Takayama, K. D. Costa, and J. W. Covell Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1510 - H1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Rosen, T. Edvardsen, S. Lai, E. Castillo, L. Pan, M. Jerosch-Herold, S. Sinha, R. Kronmal, D. Arnett, J. R. Crouse III, et al. Left Ventricular Concentric Remodeling Is Associated With Decreased Global and Regional Systolic Function: The Multi-Ethnic Study of Atherosclerosis Circulation, August 16, 2005; 112(7): 984 - 991. [Abstract] [Full Text] [PDF]
|
|