(Circulation. 1996;94:2369-2372.)
© 1996 American Heart Association, Inc.
Articles |
Effect of Supplementary Antioxidant Vitamin Intake on Carotid Arterial Wall Intima-Media Thickness in a Controlled Clinical Trial of Cholesterol Lowering
the Statistical Consultation and Research Center and Department of Preventive Medicine (S.P.A., D.Q., W.J.M., H.N.H.), the Atherosclerosis Research Unit and Department of Medicine (C.-R.L., C.-H.L., H.N.H.), and the Department of Molecular Pharmacology and Toxicology (A.S., H.N.H.), University of Southern California, Los Angeles, and the Jet Propulsion Laboratory, California Institute of Technology, Pasadena, Calif (R.H.S.).
Correspondence to Howard N. Hodis, MD, Atherosclerosis Research Unit, Division of Cardiology, University of Southern California School of Medicine, 2250 Alcazar St, CSC 132, Los Angeles CA 90033.
Background There is accumulating experimental, epidemiological, and clinical evidence of an association between antioxidant vitamin intake and reduced risk of coronary heart disease. Using data from the Cholesterol Lowering Atherosclerosis Study (CLAS), we explored the association of self-selected supplementary antioxidant vitamin intake on the rate of progression of early preintrusive atherosclerosis.
Methods and Results CLAS was an arterial imaging trial in which nonsmoking 40- to 59-year-old men with previous coronary artery bypass graft surgery were randomized to colestipol/niacin plus diet or placebo plus diet. The rate of progression of early preintrusive atherosclerosis was determined in 146 subjects using high-resolution B-mode ultrasound quantification of the distal common carotid artery far wall intima-media thickness (IMT). From the nutritional supplement database, 22 subjects had an on-trial average supplementary vitamin E intake of 
100 IU per day (high users) and 29 subjects had an average on-trial supplementary vitamin C intake of 250 mg per day (high users). Within the placebo group, less carotid IMT progression was found for high supplementary vitamin E users when compared with low vitamin E users (0.008 versus 0.023 mm/y, P=.03). No effect of vitamin E within the drug group was found. No effect of vitamin C within the drug or placebo group was found.
Conclusions Supplementary vitamin E intake appears to be effective in reducing the progression of atherosclerosis in subjects not treated with lipid-lowering drugs while the process is still confined to the arterial wall (early preintrusive atherosclerosis).
Key Words: antioxidants • atherosclerosis • carotid arteries
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