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(Circulation. 1997;95:2075-2081.)
© 1997 American Heart Association, Inc.

Articles

Nonsurgical Septal Reduction for Hypertrophic Obstructive Cardiomyopathy

Outcome in the First Series of Patients

Charles Knight, MA, MRCP; Arvinder S. Kurbaan, MB, MRCP; Hubert Seggewiss, MD; Michael Henein, MD; Mark Gunning, MB, MRCP; Derek Harrington, MB, MRCP; Dieter Fassbender, MD; Ulrich Gleichmann, MD; Ulrich Sigwart, MD, FRCP, FESC

From the Royal Brompton Hospital (C.K., A.S.K., M.H., M.G., D.H., U.S.), London, England, and the Heart and Diabetes Centre (H.S., D.F., U.G.), Nordrhein-Westfalen, Universitatsklinik der Ruhr-Universitat Bochum, Bad Oeynhausen, Germany.

Background Some patients with hypertrophic obstructive cardiomyopathy may gain symptomatic relief from a reduction in the extent of obstruction to left ventricular outflow. We present the outcome of the first series of patients treated with an alternative method of gradient reduction using catheter techniques.

Methods and Results Eighteen patients were treated with selective intracoronary alcohol injection to induce localized septal infarction. Patients underwent echocardiographic measurement of left ventricular dimensions and Doppler echocardiographic evaluation of left ventricular outflow tract gradients before the procedure, on the first postoperative day, and at a median follow-up of 3 months after the procedure. In addition, patients underwent exercise testing and symptom evaluation before and 3 months after nonsurgical septal reduction. There was a significant reduction in left ventricular outflow tract obstruction after the procedure (preprocedure, 67 mm Hg [95% CI, 48 to 87 mm Hg]; postprocedure, 25 mm Hg [95% CI, 16 to 34 mm Hg]; P=.0006), which persisted at 3-month follow-up (22 mm Hg [95% CI, 12 to 32 mm Hg]; P=.001). This was associated with a significant improvement in symptoms. There was a small but not significant increase in exercise capacity (n=10; preprocedure, 418 seconds [95% CI, 273 to 563 seconds]; postprocedure, 452 seconds [95% CI, 283 to 621 seconds). Left ventricular dimensions were not significantly altered by nonsurgical septal reduction.

Conclusions Nonsurgical septal reduction significantly reduces left ventricular outflow tract obstruction and improves symptoms in some patients with hypertrophic obstructive cardiomyopathy. The technique may provide an alternative to surgical myomectomy in selected patients.

Key Words: cardiomyopathy • stenosis • infarction • catheter ablation • catheterization

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