(Circulation. 1997;96:2233-2238.)
© 1997 American Heart Association, Inc.
Articles |
Flow-Mediated Dilation in 9- to 11-Year-Old Children
The Influence of Intrauterine and Childhood Factors
From the Vascular Physiology Unit (C.P.M.L., A.E.D., J.E.D.), Great Ormond Street Hospital; Department of Primary Care and Population Sciences (P.H.W., O.P.), Royal Free School of Medicine; Department of Public Health Sciences (D.G.C.), St George's Hospital Medical School; and MRC Childhood Nutrition Research Centre (C.P.M.L., A.L.), Institute of Child Health, London, England.
Correspondence to Dr P.H. Whincup, Cardiovascular Research Unit, Department of Primary Care and Population Sciences, Royal Free School of Medicine, Rowland Hill St, London, NW3 2PF UK.
Background Early life factors, particularly size at birth, may influence later risk of cardiovascular disease, but a mechanism for this influence has not been established. We have examined the relation between birth weight and endothelial function (a key event in atherosclerosis) in a population-based study of children, taking into account classic cardiovascular risk factors in childhood.
Methods and Results We studied 333 British children aged 9 to 11 years in whom information on birth weight, maternal factors, and risk factors (including blood pressure, lipid fractions, preload and postload glucose levels, smoking exposure, and socioeconomic status) was available. A noninvasive ultrasound technique was used to assess the ability of the brachial artery to dilate in response to increased blood flow (induced by forearm cuff occlusion and release), an endothelium-dependent response. Birth weight showed a significant, graded, positive association with flow-mediated dilation (0.027 mm/kg; 95% CI, 0.003 to 0.051 mm/kg; P=.02). Childhood cardiovascular risk factors (blood pressure, total and LDL cholesterol, and salivary cotinine level) showed no relation with flow-mediated dilation, but HDL cholesterol level was inversely related (-0.067 mm/mmol; 95% CI, -0.021 to -0.113 mm/mmol; P=.005). The relation between birth weight and flow-mediated dilation was not affected by adjustment for childhood body build, parity, cardiovascular risk factors, social class, or ethnicity.
Conclusions Low birth weight is associated with impaired endothelial function in childhood, a key early event in atherogenesis. Growth in utero may be associated with long-term changes in vascular function that are manifest by the first decade of life and that may influence the long-term risk of cardiovascular disease.
Key Words: endothelium • cardiovascular diseases • population • risk factors • atherosclerosis
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 M. W Gillman Epidemiological challenges in studying the fetal origins of adult chronic disease Int. J. Epidemiol., April 1, 2002; 31(2): 294 - 299. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 M. Kelm Flow-mediated dilatation in human circulation: diagnostic and therapeutic aspects Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H1 - H5. [Full Text] [PDF]
|
|
|
|
|
|
D. T. Lackland, B. M. Egan, H. E. Syddall, and D. J.P. Barker Associations Between Birth Weight and Antihypertensive Medication in Black and White Medicaid Recipients Hypertension, January 1, 2002; 39(1): 179 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 K. L. Goh, A. C. Shore, M. Quinn, and J. E. Tooke Impaired Microvascular Vasodilatory Function in 3-Month-Old Infants of Low Birth Weight Diabetes Care, June 1, 2001; 24(6): 1102 - 1107. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. D. Gluckman Editorial: Nutrition, Glucocorticoids, Birth Size, and Adult Disease Endocrinology, May 1, 2001; 142(5): 1689 - 1691. [Full Text]
|
|
|
|
 |
|
 I. Booth Does the duration of breast feeding matter? BMJ, March 17, 2001; 322(7287): 625 - 626. [Full Text]
|
|
|
|
|
|
C P M Leeson, M Kattenhorn, J E Deanfield, and A Lucas Duration of breast feeding and arterial distensibility in early adult life: population based study BMJ, March 17, 2001; 322(7287): 643 - 647. [Abstract] [Full Text]
|
|
|
|
|
|
C. P. M. Leeson, M. Kattenhorn, R. Morley, A. Lucas, and J. E. Deanfield Impact of Low Birth Weight and Cardiovascular Risk Factors on Endothelial Function in Early Adult Life Circulation, March 6, 2001; 103(9): 1264 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Mortaz, M S Fewtrell, T J Cole, and A Lucas Birth weight, subsequent growth, and cholesterol metabolism in children 8-12 years old born preterm Arch. Dis. Child., March 1, 2001; 84(3): 212 - 217. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Nelson The miseries of passive smoiong Human and Experimental Toxicology, February 1, 2001; 20(2): 61 - 83. [Abstract] [PDF]
|
|
|
|
|
|
H. Martin, J. Hu, G. Gennser, and M. Norman Impaired Endothelial Function and Increased Carotid Stiffness in 9-Year-Old Children With Low Birthweight Circulation, November 28, 2000; 102(22): 2739 - 2744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ghiadoni, A. E. Donald, M. Cropley, M. J. Mullen, G. Oakley, M. Taylor, G. O'Connor, J. Betteridge, N. Klein, A. Steptoe, et al. Mental Stress Induces Transient Endothelial Dysfunction in Humans Circulation, November 14, 2000; 102(20): 2473 - 2478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hemingway, M. Shipley, P. Macfarlane, and M. Marmot Impact of socioeconomic status on coronary mortality in people with symptoms, electrocardiographic abnormalities, both or neither: the original Whitehall study 25 year follow up J Epidemiol Community Health, July 1, 2000; 54(7): 510 - 516. [Abstract] [Full Text]
|
|
|
|
|
|
K. M Godfrey and D. J. Barker Fetal nutrition and adult disease Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1344S - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. M. Leeson, P. H. Whincup, D. G. Cook, M. J. Mullen, A. E. Donald, C. A. Seymour, and J. E. Deanfield Cholesterol and Arterial Distensibility in the First Decade of Life : A Population-Based Study Circulation, April 4, 2000; 101(13): 1533 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Goodfellow, M. F Bellamy, S. T Gorman, M. Brownlee, M. W Ramsey, M. J Lewis, D. P Davies, and A. H Henderson Endothelial function is impaired in fit young adults of low birth weight Cardiovasc Res, December 1, 1998; 40(3): 600 - 606. [Abstract] [Full Text] [PDF]
|
|