| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 1997;96:2953-2958.)
© 1997 American Heart Association, Inc.
Articles |
Circulating Cardiac Troponin I in Severe Congestive Heart Failure
From the Department of Cardiology and INSERM U-390, University Hospital of Montpellier (E.M.); Sanofi Recherche (C.C.); and the Faculty of Pharmacy, CNRS UMR-9921 (B.P.), Montpellier, France.
Correspondence to Emile Missov, MD, INSERM U-390, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire de Montpellier, 34295 Montpellier Cedex 05, France. E-mail missov{at}u390.montp.inserm.fr
Background Spontaneous progression of severe congestive heart failure is structurally characterized by cellular degeneration and multiple foci of myocardial cell death. The cardiac muscle isoform of troponin I is uniquely expressed in the adult human myocardium, and an increase in its circulating levels is highly indicative of myocardial injury. Accordingly, we addressed the usefulness of cardiac troponin I as a sensitive and specific molecular marker of congestive heart failure in patients with severely reduced left ventricular performance.
Methods and Results A new generation single-step immunoenzymoluminometric assay with high analytical sensitivity was used to assess cardiac troponin I in patients with severe congestive heart failure, healthy blood donors, and hospitalized control subjects without known cardiac disease. The cardiac troponin I concentration (mean±SEM) was 72.1±15.8 pg/mL in heart failure patients and 20.4±3.2 and 36.5±5.5 pg/mL in healthy and hospitalized control subjects, respectively (P<.01 versus heart failure patients). When both control groups were considered, the mean cardiac troponin I level was 25.4±2.9 pg/mL (P<.01 versus heart failure patients). Creatine kinase MB mass and myoglobin concentrations remained within the normal range in all groups.
Conclusions These data (1) provide the first evidence for ongoing myofibrillar degradation and increased cardiac troponin I levels in patients with advanced heart failure and (2) show potential usefulness of cardiac troponin I as a specific and sensitive new serum marker molecule in severe congestive heart failure.
Key Words: cardiac troponin I • heart failure
This article has been cited by other articles:
 |
|
 |
|
  F. Zannad, W. G. Stough, B. Pitt, J. G.F. Cleland, K. F. Adams, N. L. Geller, C. Torp-Pedersen, B.-A. Kirwan, and F. Follath Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition Eur. Heart J., February 1, 2008; 29(3): 413 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Wang Significance of Circulating Troponins in Heart Failure: If These Walls Could Talk Circulation, September 11, 2007; 116(11): 1217 - 1220. [Full Text] [PDF]
|
|
|
|
|
|
R. Latini, S. Masson, I. S. Anand, E. Missov, M. Carlson, T. Vago, L. Angelici, S. Barlera, G. Parrinello, A. P. Maggioni, et al. Prognostic Value of Very Low Plasma Concentrations of Troponin T in Patients With Stable Chronic Heart Failure Circulation, September 11, 2007; 116(11): 1242 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, J. Du, C. Zhang, J. W. Walker, and X. Huang Progressive troponin I loss impairs cardiac relaxation and causes heart failure in mice Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1273 - H1281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. W. Stevenson, T. H. Le Jemtel, E. U. Alt, L. W. Stevenson, T. H. Le Jemtel, and E. U. Alt Hemodynamic Goals Are Relevant Circulation, February 21, 2006; 113(7): 1020 - 1033. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Babuin and A. S. Jaffe Troponin: the biomarker of choice for the detection of cardiac injury Can. Med. Assoc. J., November 8, 2005; 173(10): 1191 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Abbas, R. I. John, M. C. Webb, M. E. Kempson, A. N. Potter, C. P. Price, S. Vickery, and E. J. Lamb Cardiac Troponins and Renal Function in Nondialysis Patients with Chronic Kidney Disease Clin. Chem., November 1, 2005; 51(11): 2059 - 2066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mann and M. R. Bristow Mechanisms and Models in Heart Failure: The Biomechanical Model and Beyond Circulation, May 31, 2005; 111(21): 2837 - 2849. [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Kottwitz, D. E. Preziosi, M. A. Miller, J. A. Ramos-Vara, D. J. Maggs, and J. D. Bonagura Heart Failure Caused by Toxoplasmosis in a Fennec Fox (Fennecus zerda) J. Am. Anim. Hosp. Assoc., November 1, 2004; 40(6): 501 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Perna, S. M. Macin, J. P. C. Canella, N. Augier, J. L. R. Stival, J. R. Cialzeta, A. E. Pitzus, E. H. Garcia, R. Obregon, M. Brizuela, et al. Ongoing Myocardial Injury in Stable Severe Heart Failure: Value of Cardiac Troponin T Monitoring for High-Risk Patient Identification Circulation, October 19, 2004; 110(16): 2376 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Sato, T Kita, Y Takatsu, and T Kimura Biochemical markers of myocyte injury in heart failure Heart, October 1, 2004; 90(10): 1110 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Roongsritong, I. Warraich, and C. Bradley Common Causes of Troponin Elevations in the Absence of Acute Myocardial Infarction: Incidence and Clinical Significance Chest, May 1, 2004; 125(5): 1877 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Jortani, S. D. Prabhu, and R. Valdes Jr Strategies for Developing Biomarkers of Heart Failure Clin. Chem., February 1, 2004; 50(2): 265 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ritter, P. A. Lee, J. F. Taylor, L. Hsu, J. D. Cohen, H. D. Chung, and K. S. Virgo Troponin I in Patients without Chest Pain Clin. Chem., January 1, 2004; 50(1): 112 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Imazio, B. Demichelis, E. Cecchi, R. Belli, A. Ghisio, M. Bobbio, and R. Trinchero Cardiac troponin i in acute pericarditis J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2144 - 2148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ishii, W. Cui, F. Kitagawa, T. Kuno, Y. Nakamura, H. Naruse, Y. Mori, T. Ishikawa, Y. Nagamura, T. Kondo, et al. Prognostic Value of Combination of Cardiac Troponin T and B-Type Natriuretic Peptide after Initiation of Treatment in Patients with Chronic Heart Failure Clin. Chem., December 1, 2003; 49(12): 2020 - 2026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Goto, H Takase, T Toriyama, T Sugiura, K Sato, R Ueda, and Y Dohi Circulating concentrations of cardiac proteins indicate the severity of congestive heart failure Heart, November 1, 2003; 89(11): 1303 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Horwich, J. Patel, W. R. MacLellan, and G. C. Fonarow Cardiac Troponin I Is Associated With Impaired Hemodynamics, Progressive Left Ventricular Dysfunction, and Increased Mortality Rates in Advanced Heart Failure Circulation, August 19, 2003; 108(7): 833 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Cannon and A. G.G. Turpie Unstable Angina and Non-ST-Elevation Myocardial Infarction: Initial Antithrombotic Therapy and Early Invasive Strategy Circulation, June 3, 2003; 107(21): 2640 - 2645. [Full Text] [PDF]
|
|
|
|
|
|
R. Labugger, J. A. Simpson, M. Quick, H. A. Brown, C. E. Collier, I. Neverova, and J. E. Van Eyk Strategy for Analysis of Cardiac Troponins in Biological Samples with a Combination of Affinity Chromatography and Mass Spectrometry Clin. Chem., June 1, 2003; 49(6): 873 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. O'Connor, W. A. Gattis, K. F. Adams Jr, V. Hasselblad, B. Chandler, A. Frey, I. Kobrin, M. Rainisio, M. R. Shah, J. Teerlink, et al. Tezosentan in patients with acuteheart failure and acute coronary syndromes: Results of the randomized intravenous tezosentan study (ritz-4) J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1452 - 1457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kamblock, L. Payot, B. Iung, P. Costes, T. Gillet, C. Le Goanvic, P. Lionet, B. Pagis, J. Pasche, C. Roy, et al. Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels Eur. Heart J., May 1, 2003; 24(9): 855 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Bertrand, M. L. Simoons, K. A.A. Fox, L. C. Wallentin, C. W. Hamm, E. McFadden, P. J. De Feyter, G. Specchia, and W. Ruzyllo Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation Eur. Heart J., December 1, 2002; 23(23): 1809 - 1840. [Full Text] [PDF]
|
|
|
|
 |
|
 A. van der Laarse Hypothesis: troponin degradation is one of the factors responsible for deterioration of left ventricular function in heart failure Cardiovasc Res, October 1, 2002; 56(1): 8 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Colantonio, W. Pickett, R. J. Brison, C. E. Collier, and J. E. Van Eyk Detection of Cardiac Troponin I Early after Onset of Chest Pain in Six Patients Clin. Chem., April 1, 2002; 48(4): 668 - 671. [Full Text] [PDF]
|
|
|
|
 |
|
 I Weinberg, T Cukierman, and T Chajek-Shaul Troponin T elevation in lobar lung disease Postgrad. Med. J., April 1, 2002; 78(918): 244 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C-K Wong and H D White Recognising "painless" heart attacks Heart, January 1, 2002; 87(1): 3 - 5. [Full Text] [PDF]
|
|
|
|
 |
|
 N.J. Alp, J.A. Bell, and M. Shahi A rapid troponin-I-based protocol for assessing acute chest pain QJM, December 1, 2001; 94(12): 687 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Jaffe Testing the wrong hypothesis: the failure to recognize the limitations of troponin assays J. Am. Coll. Cardiol., October 1, 2001; 38(4): 999 - 1001. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Guler, M. Bilge, B. Eryonucu, K. Uzun, M. E. Avci, and H. Dulger Cardiac Troponin I Levels in Patients with Left Heart Failure and Cor Pulmonale Angiology, May 1, 2001; 52(5): 317 - 322. [Abstract] [PDF]
|
|
|
|
|
|
E. M. Hoogerwaard, Y. Schouten, A. J. van der Kooi, J. P.M.C. Gorgels, M. de Visser, and G. T.B. Sanders Troponin T and Troponin I in Carriers of Duchenne and Becker Muscular Dystrophy with Cardiac Involvement Clin. Chem., May 1, 2001; 47(5): 962 - 963. [Full Text] [PDF]
|
|
|
|
|
|
T. Meyer, L. Binder, N. Hruska, H. Luthe, and A. B. Buchwald Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1632 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Jaffe, J. Ravkilde, R. Roberts, U. Naslund, F. S. Apple, M. Galvani, and H. Katus It's Time for a Change to a Troponin Standard Circulation, September 12, 2000; 102(11): 1216 - 1220. [Full Text] [PDF]
|
|
|
|
|
|
C. W. Hamm and E. Braunwald A Classification of Unstable Angina Revisited Circulation, July 4, 2000; 102(1): 118 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. ver Elst, H. D. Spapen, D. N. Nguyen, C. Garbar, L. P. Huyghens, and F. K. Gorus Cardiac Troponins I and T Are Biological Markers of Left Ventricular Dysfunction in Septic Shock Clin. Chem., May 1, 2000; 46(5): 650 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S J MAYNARD, I B A MENOWN, and A A J ADGEY Troponin T or troponin I as cardiac markers in ischaemic heart disease Heart, April 1, 2000; 83(4): 371 - 373. [Full Text]
|
|
|
|
 |
|
 J. Schaper, A. Elsasser, and S. Kostin The Role of Cell Death in Heart Failure Circ. Res., October 29, 1999; 85(9): 867 - 869. [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mann Mechanisms and Models in Heart Failure : A Combinatorial Approach Circulation, August 31, 1999; 100(9): 999 - 1008. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lowbeer, A. Ottosson-Seeberger, S. A. Gustafsson, R. Norrman, J. Hulting, and A. Gutierrez Increased cardiac troponin T and endothelin-1 concentrations in dialysis patients may indicate heart disease Nephrol. Dial. Transplant., August 1, 1999; 14(8): 1948 - 1955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H.B. Wu, F. S. Apple, W. B. Gibler, R. L. Jesse, M. M. Warshaw, and R. Valdes Jr. National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases Clin. Chem., July 1, 1999; 45(7): 1104 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, Y. Pi, K. J. Lee, A. S. Henkel, R. G. Gregg, P. A. Powers, and J. W. Walker Cardiac Troponin I Gene Knockout : A Mouse Model of Myocardial Troponin I Deficiency Circ. Res., January 22, 1999; 84(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|