Circulation. 1998;97:1763-1765
(Circulation. 1998;97:1763-1765.)
© 1998 American Heart Association, Inc.
Blood Pressure Gene at the Angiotensin I–Converting Enzyme Locus
Chronicle of a Gene Foretold
Florent Soubrier, MD, PhD
From INSERM U358, Hôpital Saint-Louis, Paris, France.
Correspondence to Florent Soubrier, INSERM U358, Hôpital Saint-Louis, 1 av Claude Vellefaux, 75475 Paris cedex 10, and Laboratoire de Génétique Moléculaire, Hôpital Tenon, 4, rue de la Chine, 75970 Paris cedex 20, France. E-mail florent.soubrier@tnn.ap-hop-paris.fr
Key Words: Editorials • chromosomes • pseudohypoaldosteronism • linkage disequilibrium • genetics
The candidate gene
approach allows several genes responsible for several monogenic forms
of hypertension to be identified, owing to an accurate knowledge of the
clinical and biological phenotypes of these diseases, to the
judicious choice of candidate genes whose functions are tightly related
to the phenotypes, and to the mendelian segregation of these
diseases in large pedigrees.1 However, in humans,
no gene has been definitively established as a source of genetic
variance of BP, corresponding to the putative major gene suggested by
some segregation analyses2 3 or as a
predisposing gene to hypertension. Even if some data indicate a
possible role for the angiotensinogen (AGT) gene
and if associations are found with other genes, conflicting results are
found in the literature, and no clear physiological
effect on BP has been associated with a functional variant. In the rat
model of hereditary hypertension, although >10 loci linked to BP have
been identified in various strains, no single gene has yet been
identified.
In this issue, two articles report data suggesting a linkage
between the ACE locus and DBP or mean
BP.4 5 In both studies, several hundred families
were studied, and these were not selected for a particular level of BP
but were chosen to represent large samples of the population.
The statistical methodology used to quantify, by a family approach, the
effect of the ACE locus on BP is slightly different in the
two studies. The study by O'Donnell et al4 used
a classic approach through the use of the SIBPAL . . . [Full Text of this Article]
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