From the Oregon Health Sciences University, Portland (T.S., D.J.S.); the
Laboratory of Animal Medicine and Surgery, National Heart, Lung, and Blood
Institute, Bethesda, Md (M.J., M.C.); the Center for Emerging Cardiovascular
Technologies, Duke University Medical Center, Durham, NC (C.E.F., J.B.C.,
O.T.v.R., J.K., T.R.); and the University of California, San Diego Medical
Center (B.C., A.N.D.).
Background—The lack of a suitable
noninvasive method for assessing right ventricular (RV)
volume and function has been a major deficiency of two-dimensional (2D)
echocardiography. The aim of our animal study was
to test a new real-time three-dimensional (3D) echo imaging system for
evaluating RV stroke volumes.
Methods and Results—Three to 6 months before
hemodynamic and 3D ultrasonic study, the
pulmonary valve was excised from 6 sheep (31 to 59 kg) to
induce RV volume overload. At the subsequent session, a total of 14
different steady-state hemodynamic conditions were
studied. Electromagnetic (EM) flow probes were used for obtaining
aortic and pulmonic flows. A unique phased-array volumetric 3D imaging
system developed at the Duke University Center for Emerging
Cardiovascular Technology was used for ultrasonic
imaging. Real-time volumetric images of the RV were digitally stored,
and RV stroke volumes were determined by use of parallel slices of the
3D RV data set and subtraction of end-systolic cavity volumes
from end-diastolic cavity volumes. Multiple regression
analyses showed a good correlation and agreement between the
EM-obtained RV stroke volumes (range, 16 to 42 mL/beat) and those
obtained by the new real-time 3D method (r=0.80; mean
difference, -2.7±6.4 mL/beat).
Conclusions—The real-time 3D system provided good estimation of
strictly quantified reference RV stroke volumes, suggesting an
important application of this new 3D method.
© 1998 American Heart Association, Inc.
Brief Rapid Communications
Real-time Three-dimensional Echocardiography for Determining Right Ventricular Stroke Volume in an Animal Model of Chronic Right Ventricular Volume Overload
Key Words: imaging • echocardiography • ventricles
This article has been cited by other articles:
 |
|
 |
|
  P. S. Niemann, L. Pinho, T. Balbach, C. Galuschky, M. Blankenhagen, M. Silberbach, C. Broberg, M. Jerosch-Herold, and D. J. Sahn Anatomically Oriented Right Ventricular Volume Measurements With Dynamic Three-Dimensional Echocardiography Validated by 3-Tesla Magnetic Resonance Imaging J. Am. Coll. Cardiol., October 23, 2007; 50(17): 1668 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jenkins, J. Chan, K. Bricknell, M. Strudwick, and T. H. Marwick Reproducibility of Right Ventricular Volumes and Ejection Fraction Using Real-time Three-Dimensional Echocardiography: Comparison With Cardiac MRI Chest, June 1, 2007; 131(6): 1844 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jaochim Nesser, L. Sugeng, C. Corsi, L. Weinert, J. Niel, C. Ebner, R. Steringer-Mascherbauer, F. Schmidt, G. Schummers, R. M Lang, et al. Volumetric analysis of regional left ventricular function with real-time three-dimensional echocardiography: validation by magnetic resonance and clinical utility testing Heart, May 1, 2007; 93(5): 572 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Handke, G. Heinrichs, U. Moser, F. Hirt, F. Margadant, F. Gattiker, C. Bode, and A. Geibel Transesophageal Real-Time Three-Dimensional Echocardiography: Methods and Initial In Vitro and Human In Vivo Studies J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2070 - 2076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fukuda, G. Saracino, Y. Matsumura, M. Daimon, H. Tran, N. L. Greenberg, T. Hozumi, J. Yoshikawa, J. D. Thomas, and T. Shiota Three-Dimensional Geometry of the Tricuspid Annulus in Healthy Subjects and in Patients With Functional Tricuspid Regurgitation: A Real-Time, 3-Dimensional Echocardiographic Study Circulation, July 4, 2006; 114(1_suppl): I-492 - I-498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fukuda, A. M. Gillinov, P. M. McCarthy, W. J. Stewart, J.-M. Song, T. Kihara, M. Daimon, M.-S. Shin, J. D. Thomas, and T. Shiota Determinants of Recurrent or Residual Functional Tricuspid Regurgitation After Tricuspid Annuloplasty Circulation, July 4, 2006; 114(1_suppl): I-582 - I-587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Lang, M. Bierig, R. B. Devereux, F. A. Flachskampf, E. Foster, P. A. Pellikka, M. H. Picard, M. J. Roman, J. Seward, J. Shanewise, et al. Recommendations for chamber quantification Eur J Echocardiogr, March 1, 2006; 7(2): 79 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Corsi, R. M. Lang, F. Veronesi, L. Weinert, E. G. Caiani, P. MacEneaney, C. Lamberti, and V. Mor-Avi Volumetric Quantification of Global and Regional Left Ventricular Function From Real-Time Three-Dimensional Echocardiographic Images Circulation, August 23, 2005; 112(8): 1161 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Matsumura, T. Hozumi, K. Arai, K. Sugioka, K. Ujino, Y. Takemoto, H. Yamagishi, M. Yoshiyama, and J. Yoshikawa Non-invasive assessment of myocardial ischaemia using new real-time three-dimensional dobutamine stress echocardiography: comparison with conventional two-dimensional methods Eur. Heart J., August 2, 2005; 26(16): 1625 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fukuda, J.-M. Song, A. M. Gillinov, P. M. McCarthy, M. Daimon, V. Kongsaerepong, J. D. Thomas, and T. Shiota Tricuspid Valve Tethering Predicts Residual Tricuspid Regurgitation After Tricuspid Annuloplasty Circulation, March 1, 2005; 111(8): 975 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jamal, C. Bergerot, L. Argaud, J. Loufouat, and M. Ovize Longitudinal strain quantitates regional right ventricular contractile function Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2842 - H2847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Sugeng, L Weinert, and R M Lang Left ventricular assessment using real time three dimensional echocardiography Heart, November 1, 2003; 89(90003): iii29 - 36. [Full Text] [PDF]
|
|
|
|
|
|
M. Handke, C. Jahnke, G. Heinrichs, J. Schlegel, C. Vos, D. Schmitt, C. Bode, and A. Geibel New Three-Dimensional Echocardiographic System Using Digital Radiofrequency Data--Visualization and Quantitative Analysis of Aortic Valve Dynamics With High Resolution: Methods, Feasibility, and Initial Clinical Experience Circulation, June 17, 2003; 107(23): 2876 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pasipoularides, M. Shu, A. Shah, M. S. Womack, and D. D. Glower Diastolic right ventricular filling vortex in normal and volume overload states Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1064 - H1072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Pasipoularides, M. Shu, M. S. Womack, A. Shah, O. von Ramm, and D. D. Glower RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H56 - H65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Schindera, P. S. Mehwald, D. J. Sahn, and D. Kececioglu Accuracy of Real-time Three-dimensional Echocardiography for Quantifying Right Ventricular Volume: Static and Pulsatile Flow Studies in an Anatomic In Vitro Model J. Ultrasound Med., October 1, 2002; 21(10): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X. Qin, T. Shiota, H. M. Lever, D. N. Rubin, F. Bauer, Y. J. Kim, M. Sitges, N. L. Greenberg, J. K. Drinko, M. Martin, et al. Impact of left ventricular outflow tract area on systolic outflow velocity in hypertrophic cardiomyopathy: A real-time three-dimensional echocardiographic study J. Am. Coll. Cardiol., January 16, 2002; 39(2): 308 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D J Sahn and G W Vick III Review of new techniques in echocardiography and magnetic resonance imaging as applied to patients with congenital heart disease Heart, December 1, 2001; 86(90002): ii41 - 53. [Full Text] [PDF]
|
|
|
|
|
|
T. M. Binder, R. Rosenhek, G. Porenta, G. Maurer, and H. Baumgartner Improved assessment of mitral valve stenosis by volumetric real-time three-dimensional echocardiography J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1355 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X. Qin, M. Jones, T. Shiota, N. L. Greenberg, H. Tsujino, M. S. Firstenberg, P. C. Gupta, A. D. Zetts, Y. Xu, J. P. Sun, et al. Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies J. Am. Coll. Cardiol., September 1, 2000; 36(3): 900 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gillinov, D. M. Cosgrove III, T. Shiota, J. Qin, H. Tsujino, W. J. Stewart, J. D. Thomas, M. Porqueddu, J. A. White, and E. H. Blackstone Cosgrove-Edwards Annuloplasty System: midterm results Ann. Thorac. Surg., March 1, 2000; 69(3): 717 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Binder, D. Moertl, G. Mundigler, G. Rehak, M. Franke, G. Delle-Karth, W. Mohl, H. Baumgartner, and G. Maurer Stereolithographic biomodeling to create tangible hard copies of cardiac structures from echocardiographic data: In vitro and in vivo validation J. Am. Coll. Cardiol., January 1, 2000; 35(1): 230 - 237. [Abstract] [Full Text] [PDF]
|
|