From the Départment de Cardiologie, Hôpital Charles Nicolle,
Centre Hospitalier Universitaire de Rouen, and Laboratoire de Physiologie
Lyon-Nord et Service de Cardiologie D, Université Claude Bernard (M.O.,
J.L., X.A.-F., Y.M.), Lyon, France.
Correspondence to Geneviève Derumeaux, MD, Service de Cardiologie, Hôpital Charles Nicolle, 1, Rue de Germont, 76000 Rouen, France. E-mail brice.letac{at}chu-rouen.fr
Background—Quantification of
regional myocardial function is a major unresolved issue in
cardiology. We evaluated the accuracy of pulsed
Doppler tissue imaging (DTI), a new
echocardiographic technique, to quantify regional
myocardial dysfunction induced by acute ischemia and
reperfusion.
Methods and Results—In nine open-chest anesthetized pigs,
various degrees of regional wall motion abnormalities were induced by
graded reduction of left anterior descending coronary artery
(LAD) blood flow. Pulsed Doppler tissue imaging was performed from
an epicardial apical four-chamber view with the sample placed within
the middle part of the septal wall. Peak septal velocities were
calculated during systole, isovolumic relaxation, and early and late
diastole. Regional myocardial blood flow and
systolic and diastolic dysfunctions were assessed
by radioactive microspheres and ultrasonic crystals,
respectively. Ischemia resulted in a significant rapid
reduction of systolic velocities and an early decrease in the
ratio of early to late diastolic velocities. Both changes
were detected by pulsed DTI within 5 seconds of coronary artery
occlusion. The decrease in systolic velocity significantly
correlated with both systolic shortening (r=.90,
P<.0001) and regional myocardial blood flow
(r=.96, P<.0001) during reduction of LAD
blood flow.
Conclusions—These results suggest that DTI may be a promising new
tool for the quantification of ischemia-induced regional
myocardial dysfunction.
© 1998 American Heart Association, Inc.
Basic Science Reports
Doppler Tissue Imaging Quantitates Regional Wall Motion During Myocardial Ischemia and Reperfusion
Key Words: imaging • ischemia • echocardiography • ultrasonics
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