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(Circulation. 1998;98:54-57.)
© 1998 American Heart Association, Inc.

Basic Science Reports

High-Resolution, Three-dimensional Fluorescent Imaging Reveals Multilayer Conduction Pattern in the Atrioventricular Node

Igor R. Efimov, PhD; ; Todor N. Mazgalev, PhD

From the Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio.

Correspondence to Todor Mazgalev, PhD, Department of Cardiology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195. E-mail mazgalt{at}cesmtp.ccf.org

Background—The atrioventricular node (AVN) is the only normal electrical link between the upper and lower chambers of the heart. The AVN modulates transmission of impulses, thus coordinating the contraction of the atria and ventricles.

Methods and Results—Structural and functional complexity, combined with the absence of adequate experimental techniques, has complicated attempts to directly evaluate the three-dimensional electrical activity of the AVN. Thus, despite a century of research by conventional electrophysiologic and histologic methods, even the existence of conduction through AVN is still debated.

Conclusions—Using a novel combination of microelectrode recordings and high resolution fluorescent imaging with voltage-sensitive dyes, we have for the first time clearly demonstrated three-dimensional conduction through the AVN.

Key Words: atrioventricular node • conduction • mapping • imaging

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