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(Circulation. 1998;98:1279-1285.)
© 1998 American Heart Association, Inc.


Clinical Investigation and Reports

Better Outcome for Women Compared With Men Undergoing Coronary Revascularization

A Report From the Bypass Angioplasty Revascularization Investigation (BARI)

Alice K. Jacobs, MD; Sheryl F. Kelsey, PhD; Maria Mori Brooks, PhD; David P. Faxon, MD; Bernard R. Chaitman, MD; Vera Bittner, MD; Michael B. Mock, MD; Bonnie H. Weiner, MD; Larry Dean, MD; Carla Winston, MA; Laura Drew, RN; ; George Sopko, MD, MPH

From the Evans Memorial Department of Clinical Research and the Section of Cardiology, Department of Medicine, Boston Medical Center, Boston, Mass (A.K.J.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (S.F.K., M.M.B.); University of Southern California, Los Angeles, Calif (D.P.F.); St Louis University, St Louis, Mo (B.R.C.); University of Alabama at Birmingham, Birmingham, Ala (V.B., L.D.); Mayo Clinic, Rochester, Minn (M.B.M.); University of Massachusetts Medical Center, Worcester, Mass (B.H.W.); Stanford University School of Medicine, Stanford, Calif (C.W.); Duke University Medical Center, Durham, NC (L.D.); and National Institutes of Health, Cardiology Branch, NHLBI, Bethesda, Md (G.S.).

Correspondence to Alice K. Jacobs, MD, Section of Cardiology, Boston Medical Center, 88 E Newton St, Boston, MA 02118. E-mail alice.jacobs{at}bmc.org

Background—Numerous studies have shown that women undergoing coronary revascularization procedures do so at a higher risk for an adverse outcome compared with men. However, the impact of advances in technology and improvements in techniques on in-hospital and long-term outcome after revascularization in women is unclear.

Methods and Results—We evaluated 1829 patients with symptomatic multivessel coronary disease randomized to CABG or PTCA in the Bypass Angioplasty Revascularization Investigation (BARI), of whom 27% were women. As expected, women were older (64.0 versus 60.5 years), with more congestive heart failure (14% versus 7%), hypertension (68% versus 42%), treated diabetes mellitus (31% versus 15%), and unstable angina (67% versus 61%) than men but had similar preservation of left ventricular function and extent of multivessel disease. Women assigned to surgery received the same number of total grafts but fewer internal mammary artery grafts (72% versus 85%, P<0.01), and those assigned to angioplasty had more intended lesions (76% versus 71%, P<0.01) successfully dilated than men. At an average of 5.4 years' follow-up, crude mortality rates were similar in women (12.8%) and men (12.0%). The Cox regression model adjusting for baseline differences revealed that women had a significantly lower risk of death (relative risk, 0.60; 95% CI, 0.43 to 0.84; P=0.003) but not a significantly lower risk of death plus myocardial infarction (relative risk, 0.84; 95% CI, 0.66 to 1.07; P=0.16) than men.

Conclusions—Although the unadjusted mortality rate suggests that women and men undergoing CABG and PTCA have a similar 5-year mortality, women have higher risk profiles; consequently, contrary to previous reports, female sex is an independent predictor of improved 5-year survival after we control for multiple risk factors.


Key Words: coronary disease • angioplasty • surgery • women




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E. Braunwald, E. M. Antman, J. W. Beasley, R. M. Califf, M. D. Cheitlin, J. S. Hochman, R. H. Jones, D. Kereiakes, J. Kupersmith, T. N. Levin, et al.
ACC/AHA guidelines for the management of patients with unstable angina and non-st-segment elevation myocardial infarction: A report of the american college of cardiology/ american heart association task force on practice guidelines (committee on the management of patients with unstable angina)
J. Am. Coll. Cardiol., September 1, 2000; 36(3): 970 - 1062.
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Eur Heart JHome page
J.E Roeters van Lennep, A.H Zwinderman, H.W.O Roeters van Lennep, H.E Westerveld, H.W.M Plokker, A.A Voors, A.V.G Bruschke, and E.E van der Wall
Gender differences in diagnosis and treatment of coronary artery disease from 1981 to 1997. No evidence for the Yentl syndrome
Eur. Heart J., June 1, 2000; 21(11): 911 - 918.
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Ann. Thorac. Surg.Home page
S. C. Stamou, G. Dangas, M. K.C. Dullum, A. J. Pfister, S. W. Boyce, A. S. Bafi, J. M. Garcia, and P. J. Corso
Beating heart surgery in octogenarians: perioperative outcome and comparison with younger age groups
Ann. Thorac. Surg., April 1, 2000; 69(4): 1140 - 1145.
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Arch Intern MedHome page
M. Miller, R. Byington, D. Hunninghake, B. Pitt, C. D. Furberg, and for the Prospective Randomized Evaluation of the V
Sex Bias and Underutilization of Lipid-Lowering Therapy in Patients With Coronary Artery Disease at Academic Medical Centers in the United States and Canada
Arch Intern Med, February 14, 2000; 160(3): 343 - 347.
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JAMAHome page
D. B. Mark
Sex Bias in Cardiovascular Care: Should Women Be Treated More Like Men?
JAMA, February 2, 2000; 283(5): 659 - 661.
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CirculationHome page
T. O. Cheng, A. K. Jacobs, S. F. Kelsey, M. M. Brooks, D. P. Faxon, B. R. Chaitman, V. Bittner, L. Dean, M. B. Mock, B. H. Weiner, et al.
Women Versus Men Regarding Outcome of CABG or PTCA • Response
Circulation, April 13, 1999; 99 (14): e1922 - e1926.
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Journal Watch CardiologyHome page
The BARI Study: Gender and Revascularization
Journal Watch Cardiology, November 6, 1998; 1998(1106): 3 - 3.
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JWatch Women's HealthHome page
CABG and PTCA: Similar Mortality for Women and Men
Journal Watch Women's Health, November 1, 1998; 1998(1101): 3 - 3.
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JWatch GeneralHome page
Is There Really a Gender Gap in Coronary Revascularization Prognoses?
Journal Watch (General), October 9, 1998; 1998(1009): 3 - 3.
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CirculationHome page
V. Vaccarino, J. L. Abramson, E. Veledar, and W. S. Weintraub
Sex Differences in Hospital Mortality After Coronary Artery Bypass Surgery: Evidence for a Higher Mortality in Younger Women
Circulation, March 12, 2002; 105(10): 1176 - 1181.
[Abstract] [Full Text] [PDF]