From the Evans Memorial Department of Clinical Research and the Section
of Cardiology, Department of Medicine, Boston Medical Center, Boston, Mass
(A.K.J.); Department of Epidemiology, Graduate School of Public Health,
University of Pittsburgh, Pittsburgh, Pa (S.F.K., M.M.B.); University of
Southern California, Los Angeles, Calif (D.P.F.); St Louis University, St
Louis, Mo (B.R.C.); University of Alabama at Birmingham, Birmingham, Ala
(V.B., L.D.); Mayo Clinic, Rochester, Minn (M.B.M.); University of
Massachusetts Medical Center, Worcester, Mass (B.H.W.); Stanford University
School of Medicine, Stanford, Calif (C.W.); Duke University Medical Center,
Durham, NC (L.D.); and National Institutes of Health, Cardiology Branch,
NHLBI, Bethesda, Md (G.S.).
Correspondence to Alice K. Jacobs, MD, Section of Cardiology, Boston Medical Center, 88 E Newton St, Boston, MA 02118. E-mail alice.jacobs{at}bmc.org
BackgroundNumerous studies have
shown that women undergoing coronary
revascularization procedures do so at a higher risk
for an adverse outcome compared with men. However, the impact of
advances in technology and improvements in techniques on in-hospital
and long-term outcome after revascularization in
women is unclear.
Methods and ResultsWe evaluated 1829 patients with
symptomatic multivessel coronary disease randomized
to CABG or PTCA in the Bypass Angioplasty
Revascularization Investigation (BARI), of whom
27% were women. As expected, women were older (64.0 versus 60.5
years), with more congestive heart failure (14% versus 7%),
hypertension (68% versus 42%), treated diabetes mellitus (31% versus
15%), and unstable angina (67% versus 61%) than men but had similar
preservation of left ventricular function and extent of
multivessel disease. Women assigned to surgery received the same number
of total grafts but fewer internal mammary artery grafts (72% versus
85%, P<0.01), and those assigned to angioplasty had
more intended lesions (76% versus 71%, P<0.01)
successfully dilated than men. At an average of 5.4 years' follow-up,
crude mortality rates were similar in women (12.8%) and men (12.0%).
The Cox regression model adjusting for baseline differences revealed
that women had a significantly lower risk of death (relative risk,
0.60; 95% CI, 0.43 to 0.84; P=0.003) but not a
significantly lower risk of death plus myocardial infarction (relative
risk, 0.84; 95% CI, 0.66 to 1.07; P=0.16) than men.
ConclusionsAlthough the unadjusted mortality rate suggests that
women and men undergoing CABG and PTCA have a similar 5-year mortality,
women have higher risk profiles; consequently, contrary to previous
reports, female sex is an independent predictor of improved 5-year
survival after we control for multiple risk factors.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Better Outcome for Women Compared With Men Undergoing Coronary Revascularization
A Report From the Bypass Angioplasty Revascularization Investigation (BARI)
Key Words: coronary disease angioplasty surgery women
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