(Circulation. 1998;98:2695-2701.)
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports |
Effect of Glycoprotein IIb/IIIa Receptor Blockade on Recovery of Coronary Flow and Left Ventricular Function After the Placement of Coronary-Artery Stents in Acute Myocardial Infarction
From the Deutsches Herzzentrum and 1. Medizinische Klinik der Technischen Universität München, Munich, Germany.
Correspondence to Franz-Josef Neumann, MD, Deutsches Herzzentrum und 1. Medizinische Klinik der Technischen Universität, Lazarettstraße 36, 81636 München, Germany. E-mail neumann{at}dhm.mhn.de
Background—Apart from its established effects on vessel patency after percutaneous coronary revascularization, glycoprotein IIb/IIIa receptor blockade by abciximab may improve myocardial perfusion by inhibition of the interaction of platelets and platelet aggregates with the microvasculature. We investigated the effect of abciximab with stent placement in acute myocardial infarction.
Methods and Results—In a prospective randomized trial, patients undergoing stenting in acute myocardial infarction within 48 hours after onset of symptoms were randomly assigned to receive either standard-dose heparin or abciximab plus low-dose heparin. Immediately after the procedure and at 14-day angiographic follow-up, we assessed flow velocity in the recanalized vessel with the Doppler wire and regional wall motion by the centerline method. End points were changes in papaverine-induced peak flow velocities and in wall motion indices. We assigned 98 patients to standard heparin and 102 to abciximab. We obtained 152 paired flow measurements and 151 paired left ventricular function studies. Residual stenoses of the treated lesions did not differ between the 2 groups. Improvement of peak flow velocity (mean [95% CI]: 18.1 cm/s [13.6 to 22.6 cm/s], n=80, versus 10.4 cm/s [5.4 to 15.4 cm/s], n=72, P=0.024) and wall motion index (0.44 SD/chord [0.29 to 0.59 SD/chord], n=79 versus 0.15 SD/chord [0.00 to 0.30 SD/chord], n=72, P=0.007) was significantly greater in patients assigned to abciximab than in those on heparin alone. At follow-up, the abciximab group had a higher global left ventricular ejection fraction than the heparin group (62% [59% to 65%] versus 56% [53% to 59%], P=0.003).
Conclusions—Abciximab had important effects beyond the maintenance of large-vessel patency. It improved the recovery of microvascular perfusion and concomitantly enhanced the recovery of contractile function in the area at risk.
Key Words: myocardial infarction • stents • glycoproteins • blood flow • ventricles
This article has been cited by other articles:
 |
|
 |
|
  M. R. Le May, G. A. Wells, C. A. Glover, D. Y. So, M. Froeschl, J.-F. Marquis, E. R. O'Brien, M. Turek, A. Thomas, M. Kass, et al. Primary Percutaneous Coronary Angioplasty With and Without Eptifibatide in ST-Segment Elevation Myocardial Infarction: A Safety and Efficacy Study of Integrilin-Facilitated Versus Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction (ASSIST) Circ Cardiovasc Interv, August 1, 2009; 2(4): 330 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mehilli, A. Kastrati, S. Schulz, S. Frungel, S. G. Nekolla, W. Moshage, F. Dotzer, K. Huber, J. Pache, J. Dirschinger, et al. Abciximab in Patients With Acute ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention After Clopidogrel Loading: A Randomized Double-Blind Trial Circulation, April 14, 2009; 119(14): 1933 - 1940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Fokkema, P. J. Vlaar, T. Svilaas, M. Vogelzang, D. Amo, G. F.H. Diercks, A. J.H. Suurmeijer, and F. Zijlstra Incidence and clinical consequences of distal embolization on the coronary angiogram after percutaneous coronary intervention for ST-elevation myocardial infarction Eur. Heart J., April 2, 2009; 30(8): 908 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ortolani, A. Marzocchi, C. Marrozzini, T. Palmerini, F. Saia, N. Taglieri, F. Baldazzi, G. Dall'Ara, P. Nardini, S. Gianstefani, et al. Long-term effectiveness of early administration of glycoprotein IIb/IIIa agents to real-world patients undergoing primary percutaneous interventions: results of a registry study in an ST-elevation myocardial infarction network Eur. Heart J., January 1, 2009; 30(1): 33 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marzocchi, A. Manari, G. Piovaccari, C. Marrozzini, S. Marra, P. Magnavacchi, P. Sangiorgio, L. Marinucci, N. Taglieri, G. Gordini, et al. Randomized comparison between tirofiban and abciximab to promote complete ST-resolution in primary angioplasty: results of the facilitated angioplasty with tirofiban or abciximab (FATA) in ST-elevation myocardial infarction trial Eur. Heart J., December 2, 2008; 29(24): 2972 - 2980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. De Luca Adjunctive antithrombotic therapy during primary percutaneous coronary intervention Eur. Heart J. Suppl., December 1, 2008; 10(suppl_J): J2 - J14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Pries, H. Habazettl, G. Ambrosio, P. R. Hansen, J. C. Kaski, V. Schachinger, H. Tillmanns, G. Vassalli, I. Tritto, M. Weis, et al. A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings Cardiovasc Res, November 1, 2008; 80(2): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Pineda, X. Merino, S. Gispert, P. Mahia, B. Garcia, and R. Dominguez-Oronoz No-Reflow Phenomenon in Cardiac MRI: Diagnosis and Clinical Implications Am. J. Roentgenol., July 1, 2008; 191(1): 73 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Thiele, K. Schindler, J. Friedenberger, I. Eitel, G. Furnau, E. Grebe, S. Erbs, A. Linke, S. Mobius-Winkler, D. Kivelitz, et al. Intracoronary Compared With Intravenous Bolus Abciximab Application in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: The Randomized Leipzig Immediate Percutaneous Coronary Intervention Abciximab IV Versus IC in ST-Elevation Myocardial Infarction Trial Circulation, July 1, 2008; 118(1): 49 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. May, P. Seizer, and M. Gawaz Platelets: Inflammatory Firebugs of Vascular Walls Arterioscler Thromb Vasc Biol, March 1, 2008; 28(3): s5 - s10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Svilaas, P. J. Vlaar, I. C. van der Horst, G. F.H. Diercks, B. J.G.L. de Smet, A. F.M. van den Heuvel, R. L. Anthonio, G. A. Jessurun, E.-S. Tan, A. J.H. Suurmeijer, et al. Thrombus Aspiration during Primary Percutaneous Coronary Intervention N. Engl. J. Med., February 7, 2008; 358(6): 557 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Vetrovec Improving Reperfusion in Patients with Myocardial Infarction N. Engl. J. Med., February 7, 2008; 358(6): 634 - 637. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maioli, F. Bellandi, M. Leoncini, A. Toso, and R. P. Dabizzi Randomized Early Versus Late Abciximab in Acute Myocardial Infarction Treated With Primary Coronary Intervention (RELAx-AMI Trial) J. Am. Coll. Cardiol., April 10, 2007; 49(14): 1517 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R J van der Schaaf, J R Timmer, J P Ottervanger, J C A Hoorntje, M-J de Boer, H Suryapranata, F Zijlstra, and J-H E Dambrink Long-term impact of multivessel disease on cause-specific mortality after ST elevation myocardial infarction treated with reperfusion therapy Heart, December 1, 2006; 92(12): 1760 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ndrepepa, A. Kastrati, J. Mehilli, F.-J. Neumann, J. ten Berg, O. Bruskina, F. Dotzer, M. Seyfarth, J. Pache, J. Dirschinger, et al. Age-Dependent Effect of Abciximab in Patients With Acute Coronary Syndromes Treated With Percutaneous Coronary Interventions Circulation, November 7, 2006; 114(19): 2040 - 2046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Silva-Orrego, P. Colombo, R. Bigi, D. Gregori, A. Delgado, P. Salvade, J. Oreglia, P. Orrico, A. de Biase, G. Piccalo, et al. Thrombus Aspiration Before Primary Angioplasty Improves Myocardial Reperfusion in Acute Myocardial Infarction: The DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) Study J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1552 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Heer, U Zeymer, C Juenger, A K Gitt, H Wienbergen, R Zahn, M Gottwik, J Senges, and for the Acute Coronary Syndromes (ACOS) Registry I Beneficial effects of abciximab in patients with primary percutaneous intervention for acute ST segment elevation myocardial infarction in clinical practice Heart, October 1, 2006; 92(10): 1484 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ali, D. Cox, N. Dib, B. Brodie, D. Berman, N. Gupta, K. Browne, R. Iwaoka, M. Azrin, D. Stapleton, et al. Rheolytic Thrombectomy With Percutaneous Coronary Intervention for Infarct Size Reduction in Acute Myocardial Infarction: 30-Day Results From a Multicenter Randomized Study J. Am. Coll. Cardiol., July 18, 2006; 48(2): 244 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Mangano, Y. Miao, I. C. Tudor, C. Dietzel, for the Investigators of the Multicenter Study of, and and the Ischemia Research and Education Foundation Post-Reperfusion Myocardial Infarction: Long-Term Survival Improvement Using Adenosine Regulation With Acadesine J. Am. Coll. Cardiol., July 4, 2006; 48(1): 206 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Bittl The Future of an Illusion J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2380 - 2383. [Full Text] [PDF]
|
|
|
|
|
|
J P S Henriques, F Zijlstra, A W J van 't Hof, M-J de Boer, J-H E Dambrink, A T M Gosselink, J C A Hoorntje, J P Ottervanger, and H Suryapranata Primary percutaneous coronary intervention versus thrombolytic treatment: long term follow up according to infarct location Heart, January 1, 2006; 92(1): 75 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E J Smith, A Mathur, and M T Rothman Recent advances in primary percutaneous intervention for acute myocardial infarction Heart, December 1, 2005; 91(12): 1533 - 1536. [Full Text] [PDF]
|
|
|
|
|
|
H. Ince, M. Petzsch, H. D. Kleine, H. Schmidt, T. Rehders, T. Korber, C. Schumichen, M. Freund, and C. A. Nienaber Preservation From Left Ventricular Remodeling by Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Use of Granulocyte-Colony-Stimulating Factor (FIRSTLINE-AMI) Circulation, November 15, 2005; 112(20): 3097 - 3106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ndrepepa, A. Kastrati, M. Schwaiger, J. Mehilli, C. Markwardt, A. Dibra, J. Dirschinger, and A. Schomig Relationship Between Residual Blood Flow in the Infarct-Related Artery and Scintigraphic Infarct Size, Myocardial Salvage, and Functional Recovery in Patients with Acute Myocardial Infarction J. Nucl. Med., November 1, 2005; 46(11): 1782 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. Hang, C.-P. Wang, H.-K. Yip, C.-H. Yang, G. B.-F. Guo, C.-J. Wu, and S.-M. Chen Early Administration of Intracoronary Verapamil Improves Myocardial Perfusion During Percutaneous Coronary Interventions for Acute Myocardial Infarction Chest, October 1, 2005; 128(4): 2593 - 2598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Zeymer, R. Zahn, R. Schiele, W. Jansen, E. Girth, A. Gitt, K. Seidl, R. Schroder, S. Schneider, and J. Senges Early eptifibatide improves TIMI 3 patency before primary percutaneous coronary intervention for acute ST elevation myocardial infarction: results of the randomized integrilin in acute myocardial infarction (INTAMI) pilot trial Eur. Heart J., October 1, 2005; 26(19): 1971 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Thiele, L. Engelmann, K. Elsner, M. J. Kappl, W.-H. Storch, K. Rahimi, A. Hartmann, D. Pfeiffer, G. D. Kneissl, D. Schneider, et al. Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction Eur. Heart J., October 1, 2005; 26(19): 1956 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ferenc and F.-J. Neumann Efficacy of primary PCI: the microvessel perspective Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I4 - I9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Beygui and G. Montalescot The use of GP IIb/IIIa inhibitors into new perspectives: pre-catheterization laboratory administration Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I10 - I14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dudek, W. Mielecki, A. Dziewierz, J. Legutko, and J. S. Dubiel The role of thrombectomy and embolic protection devices Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I15 - I20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Migliorini and D. Antoniucci Patient selection bias in primary percutaneous coronary intervention trials: a critical issue Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I21 - I26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Danzi, L. Mauri, and F. Sozzi Percutaneous coronary intervention and beyond for ST-elevation acute myocardial infarction Eur. Heart J. Suppl., October 1, 2005; 7(suppl_K): K26 - K30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gick, N. Jander, H.-P. Bestehorn, R.-P. Kienzle, M. Ferenc, K. Werner, T. Comberg, K. Peitz, D. Zohlnhofer, V. Bassignana, et al. Randomized Evaluation of the Effects of Filter-Based Distal Protection on Myocardial Perfusion and Infarct Size After Primary Percutaneous Catheter Intervention in Myocardial Infarction With and Without ST-Segment Elevation Circulation, September 6, 2005; 112(10): 1462 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. De Luca, H. Suryapranata, R. Grimaldi, and M. Chiariello Coronary stenting and abciximab in primary angioplasty for ST-segment-elevation myocardial infarction QJM, September 1, 2005; 98(9): 633 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ince, M. Petzsch, H. D. Kleine, H. Eckard, T. Rehders, D. Burska, S. Kische, M. Freund, and C. A. Nienaber Prevention of Left Ventricular Remodeling With Granulocyte Colony-Stimulating Factor After Acute Myocardial Infarction: Final 1-year Results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial Circulation, August 30, 2005; 112(9_suppl): I-73 - I-80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lefevre, E. Garcia, B. Reimers, I. Lang, C. di Mario, A. Colombo, F.-J. Neumann, M. V. Chavarri, P. Brunel, E. Grube, et al. X-Sizer for Thrombectomy in Acute Myocardial Infarction Improves ST-Segment Resolution: Results of the X-Sizer in AMI for Negligible Embolization and Optimal ST Resolution (X AMINE ST) Trial J. Am. Coll. Cardiol., July 19, 2005; 46(2): 246 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schomig, J. Mehilli, D. Antoniucci, G. Ndrepepa, C. Markwardt, F. Di Pede, S. G. Nekolla, K. Schlotterbeck, H. Schuhlen, J. Pache, et al. Mechanical Reperfusion in Patients With Acute Myocardial Infarction Presenting More Than 12 Hours From Symptom Onset: A Randomized Controlled Trial JAMA, June 15, 2005; 293(23): 2865 - 2872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sciagra, G. Parodi, A. Pupi, A. Migliorini, R. Valenti, G. Moschi, G. M. Santoro, G. Memisha, and D. Antoniucci Gated SPECT Evaluation of Outcome After Abciximab-Supported Primary Infarct Artery Stenting for Acute Myocardial Infarction: The Scintigraphic Data of the Abciximab and Carbostent Evaluation (ACE) Randomized Trial J. Nucl. Med., May 1, 2005; 46(5): 722 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. De Luca, H. Suryapranata, G. W. Stone, D. Antoniucci, J. E. Tcheng, F.-J. Neumann, F. Van de Werf, E. M. Antman, and E. J. Topol Abciximab as Adjunctive Therapy to Reperfusion in Acute ST-Segment Elevation Myocardial Infarction: A Meta-analysis of Randomized Trials JAMA, April 13, 2005; 293(14): 1759 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Iglesias-Garriz, F. Fernandez-Vazquez, A. Perez, J. Jimenez-Bonilla, C. Garrote, P. Uriarte, and C. DelaFuente Preinfarction Angina Limits Myocardial Infarction Size in Nondiabetic Patients Treated With Primary Coronary Angioplasty Chest, April 1, 2005; 127(4): 1116 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schomig and A. Kastrati Distal Embolic Protection in Patients With Acute Myocardial Infarction: Attractive Concept But No Evidence of Benefit JAMA, March 2, 2005; 293(9): 1116 - 1118. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Barrabes, D. Garcia-Dorado, M. Mirabet, J. Inserte, L. Agullo, B. Soriano, A. Massaguer, F. Padilla, R.-M. Lidon, and J. Soler-Soler Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia J. Am. Coll. Cardiol., January 18, 2005; 45(2): 293 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gyongyosi, H. Domanovits, W. Benzer, M. Haugk, B. Heinisch, G. Sodeck, R. Hodl, G. Gaul, G. Bonner, J. Wojta, et al. Use of abciximab prior to primary angioplasty in STEMI results in early recanalization of the infarct-related artery and improved myocardial tissue reperfusion - results of the Austrian multi-centre randomized ReoPro-BRIDGING Study Eur. Heart J., December 1, 2004; 25(23): 2125 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G S Werner, U Emig, P Bahrmann, M Ferrari, and H R Figulla Recovery of impaired microvascular function in collateral dependent myocardium after recanalisation of a chronic total coronary occlusion Heart, November 1, 2004; 90(11): 1303 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ndrepepa, A. Kastrati, F.-J. Neumann, C. Schmitt, J. Mehilli, and A. Schomig Five-year outcome of patients with acute myocardial infarction enrolled in a randomised trial assessing the value of abciximab during coronary artery stenting Eur. Heart J., September 2, 2004; 25(18): 1635 - 1640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner and S. H. Rezkalla Cardiac protection during acute myocardial infarction: Where do we stand in 2004? J. Am. Coll. Cardiol., July 21, 2004; 44(2): 276 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Chaitman and M. J. Lim No reflow and the quest to achieve optimal perfusion during the acute phase of myocardial infarction J. Am. Coll. Cardiol., July 21, 2004; 44(2): 313 - 315. [Full Text] [PDF]
|
|
|
|
|
|
J. R Timmer, J. P. Ottervanger, K. Thomas, J. C.A Hoorntje, M.-J. de Boer, H. Suryapranata, F. Zijlstra, and on behalf of the Zwolle myocardial infarction stud Long-term, cause-specific mortality after myocardial infarction in diabetes Eur. Heart J., June 1, 2004; 25(11): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Montalescot, H R Andersen, D Antoniucci, A Betriu, M J de Boer, L Grip, F J Neumann, and M T Rothman Recommendations on percutaneous coronary intervention for the reperfusion of acute ST elevation myocardial infarction Heart, June 1, 2004; 90(6): e37 - e37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Buttner and F.-J. Neumann Tirofiban for catheter intervention in acute myocardial infarction? Eur. Heart J., May 2, 2004; 25(10): 807 - 809. [Full Text] [PDF]
|
|
|
|
|
|
M. Leoncini, F. Bellandi, R. Sciagra, M. Maioli, A. Toso, A. Coppola, S. Sestini, A. Mennuti, R. P. Dabizzi, and A. Pupi Gated SPECT Evaluation of the Relationship Between Admission Troponin I, Myocardial Salvage, and Functional Recovery in Acute Myocardial Infarction Treated by Abciximab and Early Primary Angioplasty J. Nucl. Med., May 1, 2004; 45(5): 739 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kastrati, J. Mehilli, S. Nekolla, H. Bollwein, S. Martinoff, J. Pache, H. Schuhlen, M. Seyfarth, M. Gawaz, F.-J. Neumann, et al. A randomized trial comparing myocardial salvage achieved by coronary stenting versus balloon angioplasty in patients with acute myocardial infarction considered ineligible for reperfusion therapy J. Am. Coll. Cardiol., March 3, 2004; 43(5): 734 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kastrati, J. Mehilli, K. Schlotterbeck, F. Dotzer, J. Dirschinger, C. Schmitt, S. G. Nekolla, M. Seyfarth, S. Martinoff, C. Markwardt, et al. Early Administration of Reteplase Plus Abciximab vs Abciximab Alone in Patients With Acute Myocardial Infarction Referred for Percutaneous Coronary Intervention: A Randomized Controlled Trial JAMA, February 25, 2004; 291(8): 947 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gawaz Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium Cardiovasc Res, February 15, 2004; 61(3): 498 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Galiuto Optimal therapeutic strategies in the setting of post-infarct no reflow: the need for a pathogenetic classification Heart, February 1, 2004; 90(2): 123 - 125. [Full Text] [PDF]
|
|
|
|
|
|
M Sezer, Y Nisanci, B Umman, E Yilmaz, A Olcay, F Erzengin, and O Ozsaruhan New support for clarifying the relation between ST segment resolution and microvascular function: degree of ST segment resolution correlates with the pressure derived collateral flow index Heart, February 1, 2004; 90(2): 146 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kunichika, O. Ben-Yehuda, S. Lafitte, N. Kunichika, B. Peters, and A. N. DeMaria Effects of glycoprotein iib/iiia inhibition on microvascular flow after coronary reperfusion: A quantitative myocardial contrast echocardiography study J. Am. Coll. Cardiol., January 21, 2004; 43(2): 276 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner and W. Dai Glycoprotein IIb/IIIa inhibitors and no-reflow J. Am. Coll. Cardiol., January 21, 2004; 43(2): 284 - 286. [Full Text] [PDF]
|
|
|
|
|
|
D. Antoniucci, A. Rodriguez, A. Hempel, R. Valenti, A. Migliorini, F. Vigo, G. Parodi, C. Fernandez-Pereira, G. Moschi, A. Bartorelli, et al. A randomized trial comparing primary infarct artery stenting with or without abciximab in acute myocardial infarction J. Am. Coll. Cardiol., December 3, 2003; 42(11): 1879 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Herrmann Optimizing outcomes in ST-segment elevation myocardial infarction J. Am. Coll. Cardiol., October 15, 2003; 42(8): 1357 - 1359. [Full Text] [PDF]
|
|
|
|
|
|
M. Napodano, G. Pasquetto, S. Sacca, C. Cernetti, V. Scarabeo, P. Pascotto, and B. Reimers Intracoronary thrombectomy improves myocardial reperfusion in patients undergoing direct angioplasty for acute myocardial infarction J. Am. Coll. Cardiol., October 15, 2003; 42(8): 1395 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P Dobesh, S. L Lanfear, J. R Abu-Shanab, J. E Lakamp, S. Gowda, and M. Y Haikal Outcomes with Changes in Prescribing of Glycoprotein IIb/IIIa Inhibitors in PCI Ann. Pharmacother., October 1, 2003; 37(10): 1375 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Tcheng, D. E. Kandzari, C. L. Grines, D. A. Cox, M. B. Effron, E. Garcia, J. J. Griffin, G. Guagliumi, T. Stuckey, M. Turco, et al. Benefits and Risks of Abciximab Use in Primary Angioplasty for Acute Myocardial Infarction: The Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Trial Circulation, September 16, 2003; 108(11): 1316 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Heitzer, I. Ollmann, K. Koke, T. Meinertz, and T. Munzel Platelet Glycoprotein IIb/IIIa Receptor Blockade Improves Vascular Nitric Oxide Bioavailability in Patients With Coronary Artery Disease Circulation, August 5, 2003; 108(5): 536 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Feldman, P. Coste, A. Furber, P. Dupouy, M. S. Slama, J.-P. Monassier, C. Tron, A. Lafont, M. Faraggi, D. Le Guludec, et al. Incomplete Resolution of ST-Segment Elevation Is a Marker of Transient Microcirculatory Dysfunction After Stenting for Acute Myocardial Infarction Circulation, June 3, 2003; 107(21): 2684 - 2689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A Crouch, J. M Nappi, and K. I Cheang Glycoprotein IIb/IIIa Receptor Inhibitors in Percutaneous Coronary Intervention and Acute Coronary Syndrome Ann. Pharmacother., June 1, 2003; 37(6): 860 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Grines, P. Serruys, and W. W. O'Neill Fibrinolytic Therapy: Is It A Treatment of the Past? Circulation, May 27, 2003; 107(20): 2538 - 2542. [Full Text] [PDF]
|
|
|
|
|
|
S. J. Brener, S. G. Ellis, J. Schneider, C. Apperson-Hansen, and E. J. Topol Abciximab-facilitated percutaneous coronary intervention and long-term survival--a prospective single-center registry Eur. Heart J., April 1, 2003; 24(7): 630 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dibra, J. Mehilli, J. Dirschinger, J.u. Pache, J. Neverve, M. Schwaiger, A. Schomig, and A. Kastrati Thrombolysis in myocardial infarction myocardial perfusion grade in angiography correlates with myocardial salvage in patients with acute myocardial infarction treated with stenting or thrombolysis J. Am. Coll. Cardiol., March 19, 2003; 41(6): 925 - 929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Haager, P. Christott, N. Heussen, W. Lepper, P. Hanrath, and R. Hoffmann Prediction of clinical outcome after mechanical revascularization in acute myocardial infarction by markers of myocardial reperfusion J. Am. Coll. Cardiol., February 19, 2003; 41(4): 532 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.M.J. Marques and C.A. Visser Myocardial contrast echocardiography in the assessment of pharmacologic intervention of the reperfusion injury Eur. Heart J., January 1, 2003; 24(1): 19 - 20. [Full Text] [PDF]
|
|
|
|
|
|
A.S Petronio, D Rovai, G Musumeci, R Baglini, C Nardi, U Limbruno, C Palagi, D Volterrani, and M Mariani Effects of abciximab on microvascular integrity and left ventricular functional recovery in patients with acute infarction treated by primary coronary angioplasty Eur. Heart J., January 1, 2003; 24(1): 67 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Marzilli, G. Sambuceti, R. Testa, and S. Fedele Platelet glycoprotein IIb/IIIa receptor blockade and coronary resistance in unstable angina J. Am. Coll. Cardiol., December 18, 2002; 40(12): 2102 - 2109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Dalby and G Montalescot Transfer for primary angioplasty: who and how? Heart, December 1, 2002; 88(6): 570 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-J. Neumann and N. Jander How to best counteract the enemies? By ensuring adequate oxygen delivery Eur. Heart J. Suppl., November 1, 2002; 4(suppl_G): G35 - G42. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Kern Patterns of Left Ventricular Dilatation With an Opened Artery After Acute Myocardial Infarction: Missing Links to Long-Term Prognosis Circulation, October 29, 2002; 106(18): 2294 - 2295. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kupatt, R. Wichels, J. Horstkotte, F. Krombach, H. Habazettl, and P. Boekstegers Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion J. Leukoc. Biol., September 1, 2002; 72(3): 455 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Herrmann, G. W. Stone, C. L. Grines, and J. E. Tcheng Comparison of Angioplasty with Stenting in Acute Myocardial Infarction N. Engl. J. Med., August 1, 2002; 347(5): 367 - 368. [Full Text] [PDF]
|
|
|
|
|
|
T. Palmerini, M. A. Nedelman, L. E. Scudder, M. T. Nakada, R. E. Jordan, S. Smyth, R. E. Gordon, J. T. Fallon, and B. S. Coller Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates J. Am. Coll. Cardiol., July 17, 2002; 40(2): 360 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.P.S. Henriques, F. Zijlstra, J.P. Ottervanger, M.-J. de Boer, A.W.J. van 't Hof, J.C.A. Hoorntje, and H. Suryapranata Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction Eur. Heart J., July 2, 2002; 23(14): 1112 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Aymong, M. J. Curtis, M. Youssef, M. M. Graham, L. Shewchuk, W. Leschuk, and T. J. Anderson Abciximab Attenuates Coronary Microvascular Endothelial Dysfunction After Coronary Stenting Circulation, June 25, 2002; 105(25): 2981 - 2985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Constantinides, T S N Lo, M Been, and M F Shiu Early experience with a helical coronary thrombectomy device in patients with acute coronary thrombosis. Heart, May 1, 2002; 87(5): 455 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ambrose and E. E. Martinez A New Paradigm for Plaque Stabilization Circulation, April 23, 2002; 105(16): 2000 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Andrassy, M Zielinska, R Busch, A Schomig, and C Firschke Myocardial blood volume and the amount of viable myocardium early after mechanical reperfusion of acute myocardial infarction: prospective study using venous contrast echocardiography Heart, April 1, 2002; 87(4): 350 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Stone, C. L. Grines, D. A. Cox, E. Garcia, J. E. Tcheng, J. J. Griffin, G. Guagliumi, T. Stuckey, M. Turco, J. D. Carroll, et al. Comparison of Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction N. Engl. J. Med., March 28, 2002; 346(13): 957 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B R Brodie and T D Stuckey Mechanical reperfusion therapy for acute myocardial infarction: Stent PAMI, ADMIRAL, CADILLAC and beyond Heart, March 1, 2002; 87(3): 191 - 192. [Full Text] [PDF]
|
|
|
|
|
|
G. W. Stone, M. A. Peterson, A. J. Lansky, G. Dangas, R. Mehran, and M. B. Leon Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction J. Am. Coll. Cardiol., February 20, 2002; 39(4): 591 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Rezkalla and R. A. Kloner No-Reflow Phenomenon Circulation, February 5, 2002; 105(5): 656 - 662. [Full Text] [PDF]
|
|
|
|
|
|
J. Mehilli, A. Kastrati, J. Dirschinger, J. Pache, M. Seyfarth, R. Blasini, D. Hall, F.-J. Neumann, and A. Schomig Sex-Based Analysis of Outcome in Patients With Acute Myocardial Infarction Treated Predominantly With Percutaneous Coronary Intervention JAMA, January 9, 2002; 287(2): 210 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Loubeyre, M.-C. Morice, T. Lefevre, J.-F. Piechaud, Y. Louvard, and P. Dumas A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction J. Am. Coll. Cardiol., January 2, 2002; 39(1): 15 - 21. [Abstract] [Full Text] [PDF]
|
|