From the Cardiovascular Division (D.M.S., A.Z.L., S.K.) and the
Department of Biomedical Engineering (R.J.P., T.C.S., S.K.), University of
Virginia School of Medicine, Charlottesville.
Correspondence to Sanjiv Kaul, MD, Cardiovascular Division, Box 158, Medical Center, University of Virginia, Charlottesville, VA 22908. E-mail sk{at}virginia.edu
Abstract
Background—Our aim was to observe
ultrasound-induced intravascular microbubble destruction in vivo and to
characterize any resultant bioeffects.
Methods and Results—Intravital microscopy was used to visualize
the spinotrapezius muscle in 15 rats during ultrasound delivery.
Microbubble destruction during ultrasound exposure caused rupture of
Conclusions—Microbubbles can be destroyed by ultrasound,
resulting in a bioeffect that could be used for local drug delivery,
angiogenesis, and vascular remodeling, or for tumor destruction.
© 1998 American Heart Association, Inc.
Brief Rapid Communication
Direct In Vivo Visualization of Intravascular Destruction of Microbubbles by Ultrasound and its Local Effects on Tissue
7-µm microvessels (mostly capillaries) and the production
of nonviable cells in adjacent tissue. The number of microvessels
ruptured and cells damaged correlated linearly
(P<0.001) with the amount of ultrasound energy
delivered.
Key Words: ultrasonics • microspheres • tissue
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