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(Circulation. 1999;99:1109-1125.)
© 1999 American Heart Association, Inc.

Abstracts of the 39th Annual Conference on Cardiovascular Disease Epidemiology and Prevention

Poster Presentations

P1 Periodontal Disease as a Risk Factor for CVD, CHD, and STROKE: The First National Health and Nutrition Examination Survey (NHANES I) and Its Follow-Up Study

Tiejian Wu, Maurizio Trevisan, Robert Genco, Joan Dorn, Karen Falkner, Christopher Sempos, National Institutes of Health, Bethesda, MA, SUNY at Buffalo, Buffalo, NY

Oral microflora associated with periodontal disease (PD) has been proposed to be a causal factor for cardiovascular disease (CVD). Data from NHANES I and its 21-year follow-up were used to test this hypothesis. Baseline periodontal status was categorized into (1)no PD, (2)gingivitis, (3)periodontitis, and (4) edentulousness. CVD events during follow-up were ascertained by hospital records for non-fatal events and death certificates for fatal events. Relative risk (RR) and 95% confidence interval (CI) were derived from Cox regression after adjusting for demographic variables and several well-established CVD risk factors. 9,962 people were free from coronary heart disease (CHD), heart failure, and cancer at baseline. 2,844 CVD, 1,468 CHD, and 803 stroke events occurred during the follow-up. Compared to no PD, RRs (CI) of CVD were 1.05 (0.93-1.18) for gingivitis, 1.17 (1.04-1.31) for periodontitis, and 1.22 (1.10-1.34) for edentulousness. RRs (CI) at similar PD levels for CHD were 1.03 (0.87-1.21), 1.14 (0.98-1.34), and 1.13 (0.98-1.32), and for stroke were 1.03 (0.81-1.31), 1.33 (1.07-1.66), and 1.30 (1.06-1.60), respectively. Analyses stratified by age group indicated that elevated risk for CVD associated with PD is manifested mainly in those aged 25-54 years at baseline. Among this age group, RRs (CI) of CVD were 1.13 (0.96-1.33) for gingivitis, 1.40 (1.16-1.68) for periodontitis, and 1.36 (1.11-1.68) for edentulousness in comparison to no PD; RRs (CI) of CHD were 1.13 (0.80-1.29), 1.33 (1.03-1.72), and 1.25 . . . [Full Text of this Article]

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