on February 25, 2002
Circulation. 2002
Published online before print February 25, 2002, doi: 10.1161/hc1102.105595
Published online before print February 25, 2002, doi: 10.1161/hc1102.105595
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Submitted on October 24, 2001
From William Beaumont Hospital, Royal Oak, Mich (C.L.G., A.W.); the Department of Medicine, University of Vermont, Burlington (M.W.W.); Minnesota Heart Clinic, Minneapolis (G.H.); the Department of Medicine, Johns Hopkins University, Baltimore, Md (J.B., J.R.); Mount Sinai Medical Center, New York, NY (J.M.); Berlex Laboratories, Montville, NJ (P.M.); and the Department of Medicine, UCSD and VA San Diego Healthcare System, San Diego, Calif (W.P., H.K.H., R.L.E.). * To whom correspondence should be addressed. E-mail: cgrines{at}beaumont.edu.
Background—The angiogenic response to myocardial ischemia can be augmented in animal models by gene transfer with the use of a replication defective adenovirus (Ad) containing a human fibroblast growth factor (FGF) gene. Methods and Results—The objectives of the Angiogenic GENe Therapy (AGENT) trial were to evaluate the safety and anti-ischemic effects of 5 ascending doses of Ad5-FGF4 in patients with angina and to select potentially safe and effective doses for subsequent study. Seventy-nine patients with chronic stable angina Canadian Cardiovascular Society class 2 or 3 underwent double-blind randomization (1:3) to placebo (n=19) or Ad5-FGF4 (n=60). Safety evaluations were performed at each visit and exercise treadmill testing (ETT) at baseline and at 4 and 12 weeks. Single intracoronary administration of Ad5-FGF4 seemed to be safe and well tolerated with no immediate adverse events. Fever of <1-day duration occurred in 3 patients in the highest-dose group. Transient, asymptomatic elevations in liver enzymes occurred in 2 patients in lower-dose groups. Serious adverse events during follow-up (mean, 311 days) were not different between placebo and Ad5-FGF4. Overall, patients who received Ad5-FGF4 tended to have greater improvements in exercise time at 4 weeks (1.3 versus 0.7 minutes, P=NS, n=79). A protocol-specified, subgroup analysis showed the greatest improvement in patients with baseline ETT Conclusions—Results show evidence of favorable anti-ischemic effects with Ad5-FGF4 compared with placebo, and it appears to be safe. Angiogenic gene transfer with Ad5-FGF4 shows promise as a new therapeutic approach to the treatment of angina pectoris.
Revised on December 31, 2001
Accepted on January 10, 2002
Angiogenic Gene Therapy (AGENT) Trial in
Patients With Stable Angina Pectoris
Cindy L. Grines MD*,
10 minutes (1.6 versus 0.6 minutes, P=0.01, n=50).
Key words: angina • angiogenesis • gene therapy • collateral circulation
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